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隐性听力损失的一种新机制——短暂性听神经脱髓鞘

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听力学及言语疾病杂志 2017年第4期25卷 441-442页

作者：盛海斌黄治物 Wan G Corfas G 上海交通大学医学院附属第九人民医院耳鼻咽喉头颈外科听力中心上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室上海200011

以往认为,听阈正常的人听觉处理能力是正常的（即使是从噪声暴露导致的暂时性阈移中恢复过来的听阈正常者）,其所出现的听力缺陷问题被归因为中枢问题。但是,最新的动物和临床研究表明,中等强度的噪声暴露或者年龄因素能够导致一种新型... 详细信息

以往认为,听阈正常的人听觉处理能力是正常的（即使是从噪声暴露导致的暂时性阈移中恢复过来的听阈正常者）,其所出现的听力缺陷问题被归因为中枢问题。但是,最新的动物和临床研究表明,中等强度的噪声暴露或者年龄因素能够导致一种新型的外周听力损失,即隐性听力损失（hidden hearing Loss,HHL）。

关键词：听力损失听神经脱髓鞘噪声暴露暂时性阈移施旺细胞听力缺陷 hearing 毛细胞突触等强度内毛细胞

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听力障碍筛查量表用于老年人群听力筛查分析

听力学及言语疾病杂志 2014年第3期22卷 230-234页

作者：胡娴亭黄治物陈建勇梅玲李蕴任燕唐职健沈敏张勤吴皓上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海200092 上海交通大学医学院耳科学研究所

目的探讨中文版老年听力障碍筛查量表(the hearing handicap inventory for the elderly-screening version,HHIE-S)用于老年人群听力筛查的可行性及实用性。方法随机选取840例年龄大于60周岁的老年人,先自行填写HHIE-S量表,然后在工作... 详细信息

目的探讨中文版老年听力障碍筛查量表(the hearing handicap inventory for the elderly-screening version,HHIE-S)用于老年人群听力筛查的可行性及实用性。方法随机选取840例年龄大于60周岁的老年人,先自行填写HHIE-S量表,然后在工作人员指导下再次填写,对比指导前后HHIE-S量表的得分,计算指导后量表的信度Cronbach'sα值,判断量表的可行性;所有填表者均进行0.5、1.0、2.0、4.0kHz纯音听阈测试,计算平均纯音听阈(PTA)值,比较筛查目标听力损失分别设定为PTA>25dB HL、PTA>40dB HL、PTA>60dB HL时,HHIE-S得分>8分与>10分及指导前后所填量表的灵敏度、特异度、阳性预测值、假阳性率及假阴性率,并根据ROC曲线及曲线下面积值(AUC),判断三种目标听力损失时量表的实用性。结果 840例老年人指导前后HHIE-S量表平均得分分别为7.6±10.6和10.8±16.7分(P8分作为听力障碍判断标准时较HHIE-S>10分灵敏度高,假阴性率低(P8分时PTA>25dB HL、PTA>40dB HL及PTA>60dB HL三种听力损失条件下ROC曲线下面积值分别为0.70±0.03、0.84±0.01及0.88±0.02。结论适当指导后,HHIE-S量表用于老年人听力筛查得分>8分即可认为存在听力障碍,目标听力损失为PTA>40dB HL时,HHIE-S量表的实用性强,汉化版HHIE-S量表可作为老年人群听力障碍有效的筛查方式。

关键词：老年性聋老年听力障碍筛查量表听力筛查 hearing handicap inventory for the elderly -screening version (HHIE-S)

Macrolides for treatment of chronic obstructive pulmonary disease

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Chinese Medical Journal 2019年第11期132卷 1261-1263页

作者： Xue-Jiao Sun Zhi-Yi He Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Respiratory and Critical Care Medicine Liuzhou General Hospital Liuzhou Guangxi 545006 China

Chronic obstructive pulmonary disease (COPD) is a common disease characterized by continued airflow limitation that is caused by inflammation and autoimmune response. Acute exacerbation of COPD (AECOPD) will increase risk of death, result in a more rapid decline of lung function, and reduce quality of life. COPD inflammation is not only limited to the lungs, but also involves multiple organs, leading to coronary heart disease, depression, skeletal muscle atrophy, and other systemic complications. Clinical study showed that long-term macrolide could reduce the frequency of AECOPD.1 However, there are still some controversies and concerns on side effects such as drug resistance, cardiac toxicity, and hearing impairment caused by long-term macrolide therapy for COPD.

关键词： Chronic obstructive pulmonary disease(COPD) hearing impairment coronary heart disease

Impact and Factors Associated with Presbycusis among 50 Years Old People of Parakou and Over in 2021

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International Journal of Otolaryngology and Head & Neck Surgery 2022年第1期11卷 56-73页

作者： Marius Claude Flatin Alexis AWC do Santos Zounon Cocouvi Bruno Ametonou Fatiou Alabi Bouraima Mé ré Roland Kimba Spé ro HR Hounkpatin Wassi Adjibabi Bernadette Vignikin-Yehouessi Faculté de Mé decine Universit&#233 de Parakou Parakou B&#233 nin Centre Hospitalier Universitaire et Dé partemental Borgou Parakou B&#233 nin Faculté des Sciences de la Santé Universit&#233 d’Abomey Calavi Cotonou B&#233 nin

Introduction: Presbycusis or age-related hearing loss is a condition of in-sidious onset with significant socio-professional repercussions. The objec-tive of this study was to determine the impact and factors associated with presbycusis among 50 years aged people or older in Parakou commune during 2021. Methods: This was a cross-sectional, descriptive, analytical study with prospective data collection. The study has involved 541 50 years aged people or older, from February to May 2021. For each of them, a questionnaire was completed, otoscopy and tone audiometry performed. The ERSA questionnaire and the logistic regression model were used to determine the impact and factors associated with presbycusis. Results: The mean age was 59.48 ± 9.80 years and the sex ratio was 1.23. The prevalence of presbycusis was 50.28%. Age ≥ 80 years (p = 0.002), male sex (p = 0.016), low educational level (p = 0.001), family history of age-related hearing loss (p = 0.018) and presence of hearing loss (p = 0.001) were significantly associated with presbycusis in multivariate analysis. Of the life domains studied, personal life (mean score = 32.9 ± 10.52) was the most affected. Similarly, communication in a noisy environment (mean score = 4.39 ± 2.39) was the most affected aspect of personal life. Conclusion: Presbycusis leads to an impairment of personal life. A good knowledge of the associated factors and an early management could contribute to the improvement of the hearing health of the elderly.

关键词： Presbycusis Elderly hearing Deafness

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An Unshakable Belief

Beijing Review 2023年第43期66卷 34-35页

作者： Tao Xing 不详

Consensus on economic recovery injects confidence into China’s market Upon hearing the news that China was to ease its COVID-19 restrictions in early December,Xie Dongfang heaved a sigh of relief.“The time has now come to reactivate my business plan,”Xie,founder of Shanghai-based scented candle brand ECOLIT,told Beijing *** year was difficult for Xie.

关键词： hearing relief market

Uninhibited by Silence

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China Today 2022年第1期71卷 68-69页

作者： DENG DI 不详

She lost her hearing,but gained *** Mengnan has a Master’s in pharmacy and is now doing her *** Tsinghua University,one of China’s most prestigious academic ***’s not just a matter of personal achievement for a young woman from a small town and an ethnic minority–she comes from a Yao family in Chenzhou,a city in Hunan Province,central China,it is an inspiration for a community that faces great odds:people with a hearing loss.

关键词： gained Hunan hearing

Novel ATL1 mutation in a Chinese family with hereditary spastic paraplegia: A case report and review of literature

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World Journal of Clinical Cases 2019年第11期7卷 1358-1366页

作者： Xue-Wen Xiao Juan Du Bin Jiao Xin-Xin Liao Lu Zhou Xi-Xi Liu Zhen-Hua Yuan Li-Na Guo Xin Wang Lu Shen Zhang-Yuan Lin Department of Neurology Xiangya Hospital Central South University Changsha 410008 Hunan Province China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 Hunan Province China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South University Changsha 410008 Hunan Province China Department of Geriatrics Neurology Xiangya Hospital Central South University Changsha 410008 Hunan Province China Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province Changsha 410008 Hunan Province China Department of Orthopedics Xiangya Hospital Central South University Changsha 410008 Hunan Province China

BACKGROUND Hereditary spastic paraplegias (HSPs) refer to a group of heterogeneous neurodegenerative diseases characterized by lower limbs spasticity and weakness. So far, over 72 genes have been found to cause HSP (SPG1-SPG72). Among autosomal dominant HSP patients, spastic paraplegia 4 (SPG4/SPAST) gene is the most common pathogenic gene, and atlastin-1 (ATL1) is the second most common one. Here we reported a novel ATL1 mutation in a Chinese spastic paraplegia 3A (SPG3A) family, which expands the clinical and genetic spectrum of ATL1 mutations. CASE SUMMARY A 9-year-old boy with progressive spastic paraplegia accompanied by right hearing loss and mental retardation for five years was admitted to our *** history was unremarkable. The family history was positive, and his grandfather and mother had similar symptoms. Neurological examinations revealed hypermyotonia in his lower limbs, hyperreflexia in knee reflex, bilateral positive Babinski signs and scissors gait. The results of blood routine test, liver function test, blood glucose test, ceruloplasmin test and vitamin test were all normal. The serum lactic acid level was significantly increased. The testing for brainstem auditory evoked potential demonstrated that the right side hearing was impaired while the left was normal. Magnetic resonance imaging showed mild atrophy of the spinal cord. The gene panel test revealed that the proband carried an ATL1 c.752A>G ***251Arg (p.Q251R) mutation, and Sanger sequencing confirmed the existence of family co-segregation. CONCLUSION We reported a novel ATL1 Q251R mutation and a novel clinical phenotype of hearing loss in a Chinese SPG3A family.

关键词： Hereditary spastic paraplegia SPG3A Atlastin-1 (ATL1) gene hearing loss Case report

Local Corruption:Halting the Vanity Affair

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China Weekly 2022年第9期 30-31页

作者： Tong Xizhong 不详

On June 29,Chenzhou City Intermediate People's Court in Hunan Province held hearings on former Jiangyong County Party secretary Zhou Lifuis corruption *** was accused of taking over 57 million yuan(US$8.43m)in bribes ... 详细信息

关键词： Hunan engaged hearing

Raising Yields Through Plant Protection

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ChinAfrica 2022年第2期14卷 36-37页

作者： LI KAIZHI 不详

Senior Chinese agronomist trains Sao Tome and Principe farmers on methods to control pests and plant diseases One afternoon last summer,Xu Zhouda welcomed his first visitor since arriving in Sao Tome and *** Lima Massago,a vegetable farmer mainly growing tomatoes,beans and peppers,came to seek help after hearing that Chinese agricultural experts were working on an agricultural cooperation project.

关键词： Plant agricultural hearing