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The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates

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Asian Journal of Andrology 2021年第1期23卷 11-15页

作者： Yetunde Ibrahim Brett Einerson Douglas T Carrell Benjamin R Emery Erica Johnstone Division of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologyUniversity of UtahSchool of MedicineSalt Lake CityUT 84132USA Division of Maternal-Fetal Medicine Department of Obstetrics and GynecologyUniversity of UtahSchool of MedicineSalt Lake CityUT 84132USA Division of Urology Department of SurgeryUniversity of UtahSchool of MedicineSalt Lake CityUT 84132USA Department of Human Genetics University of UtahSchool of MedicineSalt Lake CityUT 84132USA

This was a cohort study of in vitro fertilization(IVF)subjects at the University of Utah,Salt Lake City(UT,USA)utilizing partner *** where both the hamster egg penetration test(HEPT)and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and *** mean conventional and intracytoplasmic sperm injection(ICSI)fertilization rates were calculated in each *** performed a univariate analysis on the primary outcome comparing clinically interesting *** performed a cost-effectiveness analysis of a policy of HEPT versus universal ICSI in couples with an abnormal *** patients with a normal HEPT,there was no difference in the mean conventional fertilization rates between those with a normal and an abnormal *** was no difference in the mean conventional fertilization rates between subjects with a normal morphology without a hamster test and those with a normal HEPT without a morphology *** 1000 simulated cycles with an abnormal morphology,a policy of HEPT was cost saving compared to universal ICSI,yet produced similar fertilization *** HEPT is similar to the World Health Organization edition 5(WHO-5)morphology in predicting successful conventional fertilization while allowing decreased utilization of ICSI.A policy of HEPT for males with abnormal morphology saves cost in selecting couples for a fertilization method.

关键词： conventional fertilization hamster egg penetration test intracytoplasmic sperm injection semen analysis sperm penetration assay

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