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Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population

World Journal of Gastroenterology 2010年第36期16卷 4549-4557页

作者： Zhang Zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,Rui Zhang,Yun-Bi Ni,Hong-Ying Zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China Department of Pathology West China Hospital Sichuan University Guoxuexiang 37 Chengdu 610041 Sichuan Province China. hy_zhang@***

AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other ***:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed *** studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin ***:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by *** one patient,this presentation was accompanied by an initial severe *** symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were *** abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying *** tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal *** cases were surgically resected,three cases underwent biopsy and the two fetuses were ***,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and *** inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the *** patients are alive after a follow-up of 1-9 *** on immunohistochemistry,the endothelial cells in all cases were positiv

关键词： Infantile haemangioendothelioma Pediatrics Hepatic neoplasm Pathological diagnoses Chinese

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