检索结果-南通市图书馆

In silico assessment of human health risks caused by cyanotoxins from cyanobacteria

BIOCELL 2021年第1期45卷 65-77页

作者： JIA-FONG HONG BAGHDAD OUDDANE JIANG-SHIOU HWANG HANS-UWE DAHMS Department of Biomedical Science and Environmental Biology College of Life ScienceKaohsiung Medical UniversityKaohsiung807Taiwan Univ.Lille Laboratoire LASIREUMR CNRS 8516Equipe Physico-Chimie de l’EnvironnementLilleF-59000France Institute of Marine Biology Taiwan Ocean UniversityKeelung202Taiwan Center of Excellence for the Oceans Taiwan Ocean UniversityKeelung202Taiwan Center of Excellence for Ocean Engineering Taiwan Ocean UniversityKeelung202Taiwan Research Center for Environmental Medicine KMU-Kaohsiung Medical UniversityKaohsiung807Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen UniversityKaohsiung804Taiwan

Harmful algal blooms(HABs)that are formed by cyanobacteria have become a serious issue worldwide in recent *** can release a type of secondary metabolites called cyanotoxins into aquatic systems which may indirectly or directly provide health risks to the environment and *** provide some of the most powerful natural poisons including potent neurotoxins,hepatotoxins,cytotoxins,and endotoxins that may result in environmental health risks,and long-term morbidity and mortality to animals and *** this research,we used the chemcomputational tool Molinspiration for molecular property predictions,Pred-herg 4.2 web software for cardiac toxicity prediction,and Pred-Skin 2.0 web software for predicting skin *** are predicting some toxicological aspects of cyanobacteria here using chemcomputational tools with the hypothesis that cyanotoxins are providing a risk to human *** are using the tool Pred-herg 4.2 to predict herg channel blocking potential and the Pred-skin tool to predict skin sensitization due to *** potential of anatoxin,ambigol,the microcystin group,and lyngbyatoxin A,lyngbyatoxin B,nodularin-R,and saxitoxin were predicted to cause skin sensitization in the final results(consensus model).Anatoxin-a and lyngbyatoxin were predicted to allow GI absorption and blood–brain barrier *** the 20 predicted cyanotoxins only aeruginosin 103-A,ambigol A,and ambigol were predicted by Pred-herg 4.2 according to the applicability domain results as potential cardiotoxins with weak or moderate *** shows activity through the GPCR ligand and protease,kinase,and enzyme inhibitor.

关键词： Cyanotoxins Predictive model Molinspiration Bioactivity score herg blocker Carcinogenicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：