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Effect of prenatal exposure to diethylstilbestrol on gubernacular development in fetal male mice

Asian Journal of Andrology 2004年第4期6卷 325-329页

作者： Xue-WuJiang Jian-HongLi Tian-HuaHuang Wang-DongDeng DepartmentofPediatricSurgery SecondAffiliatedHospitalofShantouUniversityMedicalCollege（SUMC） ResearchCenterforReproductiveMedicine SUMCShantou515041China

Aim: To study the effect of prenatal exposure to diethylstilbestrol (DES) and the role of actin and proliferating cell nuclear antigen (PCNA) on testicular gubernaculum development in fetal male Kunming mice. Methods: Pregnant mice were randomly assigned to 6 groups and injected with DES subcutaneously from gestational day 9 (E9) to day 17 (E17) at doses of 0, 25, 50, 100, 200 μg·kg-1·d-1 in 0.2 mL dimethyl sulfoxide (DMSO). On E17 they were sacrificed and fetuses quickly removed for fixation. Male fetuses were sliced on serial coronal plane. Histologi-cal changes were observed under the light microscope (LM) and ultrastructural changes with the scanning and transmission electron microscopes (SEM & TEM). The expression intensity of actin and PCNA in the gubernacula was quantitated by immunohistochemistry. Results: The mortality of the fetuses was higher in the DES-treated groups than that in the DMSO and saline controls (P<0.05). Under LM the gubernacula were seen to be poorly developed with smaller bulbs. On SEM the bulbs lose the clear demarcation between the mesenchymal inner core and the muscular outer layer and looked like a small cone instead of the normal cylindrical appearance. On TEM there were some smaller disordered myofibrils and sparse cytoplasmic organelles in the gubernacular muscular cells of the treated groups. The expression intensity of actin and PCNA in the gubernacula was significantly weaker in the treated groups than that in the DMSO and saline controls (P<0.05). Conclusion: DES induces underdevelopment of the gubernacula in a dose-dependent manner in fetal male mice and down regulates the actin and PCNA expression.

关键词： diethylstilbestrol estrogen gubernaculum

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Diagnostic Approach and Management of a Unilateral Total Ectopy of the Scrotum

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Open Journal of Urology 2017年第9期7卷 139-145页

作者： Kimassoum Rimtebaye Choua Ouchemi Arya Zarif Agah Tashkand Franklin Danki Sillong Edouard Hervé Moby Mpah Mignagnal Kaboro Lamine Niang Serigne Magueye Gueye General Referal National Hospital of N’Djamena N’Djamena Chad Protestant Hospital of N’Gaoundere N’Gaoundere Cameroon Laquintinie Hospital of Douala Douala Cameroon “Grand Yoff” General Hospital of Dakar Dakar Senegal

Introduction: Total unilateral ectopy of the scrotum can be defined by the abnormal congenital anatomical position of the scrotum and its contents. The aim of the study is to describe the diagnostic and therapeutic approach of a total unilateral ectopy of the right scrotum. Methods: This is a clinical observation of a 46-year-old patient with a right abdominal mass evolving from birth. Analyzing the cluster of arguments clinically, operatively and anatomopathologically, allowed us to retain the diagnosis of a total unilateral ectopy of the right scrotum. The informed consent of the patient was obtained before the use of the images for scientific purposes. Conclusion: the unilateral total ectopy of the right scrotum is a rare congenital malformation of the external genitalia, which clinical diagnosis is difficult. Its management is surgical.

关键词： Testicular Ectopy Scrotum Medial Raphe Orchidopexia gubernaculum

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