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Aqueous extract of Ocimum gratissimum Linn and ascorbic acid ameliorate nicotine-induced cellular damage in murine peritoneal macrophage

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 775-782页

作者： Santanu Kar Mahapatra Subhankari Prasad Chakraborty Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar UniversityMidnapore -721 102West BengalIndia

Objective:To test the in vitro protective role of aqueous extract of Ocimum gratissimum Linn. (***) and ascorbic acid against nicotine-induced murine peritoneal macrophage. Methods:Peritoneal macrophages from mice were treated with nicotine(10 mM),nicotine (10 mM) with aqueous extract of ***(1 to 25μg/mL),and nicotine(10 mM) with ascorbic acid(0.01 mM) for 12 h in cell culture media,while the control group was treated with culture *** of free radical generation,lipid peroxidation,protein carbonyls,oxidized glutathione levels and DNA damage were observed and ***:Phytochemical analysis of aqueous extract has shown high amount of phenolics and flavonoids compound present in *** significantly increased free radical generation,lipid peroxidation,protein carbonyls,oxidized glutathione levels and DNA damage were observed in nicotine-treated group as compared to the control group:those were significantly reduced in aqueous extract of O. gratissimum and ascorbic acid supplemented ***,significantly reduced antioxidant status in nicotine exposed murine peritoneal macrophage was effectively ameliorated by these two *** the different concentration of aqueous extract of ***,the maximum protective effect was observed at 10μg/mL which does not produce any significant change in the normal ***:These findings suggest the potential use and beneficial role of *** as a modulator of nicotine-induced cellular damage in murine peritoneal macrophage.

关键词： Ocimum gratissimum Linn Nicotine Peritoneal macrophage Free radical DNA fragmentation

The Effect of Lion’s Ear (Leonotis nepetifolia) and African Basil (Ocimum gratissimum) Plant Extracts on Two-Spotted Spider Mites (Tetranychus urticae) for Improved Yield and Quality of French Beans

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Advances in Entomology 2019年第1期7卷 21-31页

作者： Kennedy Ogayo Jane Nyaanga Joshua Ogweno Joshua Ogendo Department of Crops Horticulture and SoilsEgerton UniversityEgertonKenya

An experiment to evaluate the bio-control potential of Leonotis nepetifolia and Ocimum gratissimum plant extracts against two-spotted spider mites on French beans was conducted in the field. Five plant extract concentrations (1.5%, 3.0%, 6.0% and 12.0% w/v) were applied with water and Abamectin 0.6 ml/L as controls. Mite counts were done before and after treatment application and expressed as corrected percent efficacy. The impact of the mites on the French beans was evaluated by recording percent leaf reduction and quality and quantity by number of pods, pod length, diameter and yield. There was a dose dependent response in percent mite and leaf reduction, number of pods and yield. Treatments applied at 12% w/v indicated higher mite reduction (82.75%) for L. nepetifolia and 69.06% for O. gratissimum compared to abamectin (65.76%). The lowest percent leaf reduction of 1.71% for L. nepetifolia 0.39% for O. gratissimum and abamectin (20.46%) was also at 12% w/v. Similarly, the highest number of pod (61.00) for L. nepetifolia, 48.67 for O. gratissimum compared to 28.33 abamectin and yield (0.88 kg) for L. nepetifolia and 0.90 kg for O. gratissimum was also recorded at 12% w/v compared to 0.36 kg for abamectin. There were no significant differences in pod diameter and pod length between the extracts concentrations and abamectin. The study demonstrated the efficacy of L. nepetifolia and O. gratissimum in managing two-spotted spider mite and subsequent increase in French bean yield under field conditions.

关键词： Leonotis nepetifolia Ocimum gratissimum Tetranychus urticae French Beans

Hypoglycemic efficacy of Ocimum gratissimum and Vernonia amygdalina compared with insulin and glibenclamide in type Ⅰ and type Ⅱ diabetic rat models

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Journal of Coastal Life Medicine 2017年第4期5卷 174-178页

作者： Uduak Akpan Okon Titilope Helen Olatunbosun Department of Physiology Faculty of Basic Medical SciencesCollege of Health SciencesUniversity of UyoP.M.B.1017 UyoAkwa Ibom StateNigeria

Objective: To compare the efficacy of Ocimum gratissimum (O. gratissimum) and Vernonia amygdalina (V. amygdalina) with those of insulin and ***: Type Ⅰ and Ⅱ diabetes mellitus (DM) were induced by a single intraperitoneal injection of 65 mg/kg of streptozotocin and intraperitoneal administration of nicotinamide (100 mg/kg) along with streptozotocin, respectively. The state of diabetes was confirmed weekly by testing blood glucose level using a ***: The weekly blood glucose levels were higher in type I DM than in type Ⅱ DM. Type Ⅰ DM plus O. gratissimum showed a weekly progressive significant reduction in blood glucose compared to type Ⅰ DM control. Type Ⅰ DM control showed a duration dependent significant higher blood glucose concentration compared to normal control. Type I DM plus V. amygdalina also showed a time dependent significant lower glucose level compared to normal control and type Ⅰ DM control. Combination treatment of type Ⅰ DM (O. gratissimum plus V. amygdalina) showed a significantly elevated glucose concentration compared to normal control which was similar to type I DM control. Insulin treatment in type I DM showed a weekly progressive significant reduction of glucose concentration compared to normal control and type I DM control. Type Ⅱ DM control showed a fairly constant blood glucose concentration throughout the duration of treatment that was significantly higher than that of the normal control. Type Ⅱ DM plus O. gratissimum showed a fairly steady significant reduction of glucose concentration compared to type Ⅱ DM control and normal control. Type Ⅱ DM plus V. amygdalina also showed a fairly constant significant reduction of glucose concentration compared to type Ⅱ DM control and normal control. Type II DM (O. gratissimum plus V. amygdalina) showed a slightly progressive significant reduction of glucose concentration compared to normal control and type Ⅱ DM control. Type Ⅱ DM with glibenclamide showed almost steady

关键词： Ocimum gratissimum Vernonia amygdalina Insulin Glibenclamide Diabetes mellitus Blood glucose

Iodine Fortification Study of Some Common African Vegetables

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Journal of Agricultural Chemistry and Environment 2019年第3期8卷 172-183页

作者： Chigozie John Onyinye Anarado Charity Ebere Anarado Richard Ifeanyi Areh Nonyelum Ifoh Elijah Okechukwu Eze Ebuka Ikeakor Department of Pure and Industrial Chemistry Nnamdi Azikiwe University Awka Nigeria

Iodine Deficiency Diseases (IDDs) occupy important positions in the health problems of developing countries. Salt Iodisation has been the common approach to solving these problems. However, apart from the problems of lack of compliance by salt manufacturers, and inculturation of the consumers, health conditions aggravated by high salt intake by humans have become increasingly relevant. These problems can be eliminated if the commonly produced and consumed plants are fortified with Iodine. The prospects are in the inclusion of Iodine-containing compounds in the inorganic fertilizers used by farmers. In this study, Potassium Iodide and Potassium Iodate were used as inoculants. Five different concentrations—0.1 M, 0.2 M, 0.3 M, 0.4 M, and 0.5 M of Potassium Iodide and Potassium Iodate solutions were used to inoculate the soils on which the following edible African plants were planted: Murraya koenigii;Ocimum gratissimum;Cucurbita pepo;Solanum nigrum;Amaranthus hybridus and Abelmoschus esclentus, Corchorous olitoruis, Solanum lycopersicum, Zingiber officinale, Telfairia occidentalis, Talinium triangulare, Solanum melongena. Controls were also planted. After 14 days, alkaline dry ash method was used to determine the Iodine concentrations in the plants. The results showed that Murraya koenigii showed the highest absorption of Iodine 6.90 mg/kg at 0.3 M using KI, followed by Amaranthus hybridus 6.40 mg/kg at 0.1 M. Solanum nigrum, Ocimum gratissimum and Zingiber officinale also showed good absorption. Other plants except Murraya koenigii, Ocimum gratissimum, Solanum nigrum and Zingiber officinale showed very low tolerance to KI absorption. The result also showed that Telfairia occidentalis showed the highest absorption of iodine 8.20 mg/kg at 0.2 M of KIO3 followed by Cucurbita pepo 6.40 mg/kg at also 0.2 M of KIO3. Murraya koenigii, Ocimum gratissimum, Solanum nigrum, Zingiber officinale also showed good absorption of KIO3. Some of the plants were not able to tolerate the

关键词： Iodine Deficiency Disease (IDD) Biofortification Iodisation Potassium Io-dide Potassium Iodate: Murraya koenigii Ocimum gratissimum Cucurbita pepo Solanum nigrum Amaranthus hybridus Abelmoschus esclentus Corchorous olitorius Solanum lycopersicum Zingiber officinale Telfairia occidentalis Talinium triangulare Solanum melongena

Leafy Vegetables as Potential Pathways to Heavy Metal Hazards

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Journal of Agricultural Chemistry and Environment 2019年第1期8卷 23-32页

作者： C. E. Anarado C. J. O. Anarado M. O. Okeke C. E. Ezeh N. L. Umedum P. C. Okafor Department of Pure and Industrial Chemistry Nnamdi Azikiwe University Awka Nigeria

The effect of anthropogenic activity relating to industrial and economic development has had a detrimental impact on the environment and human health, and hence the need for continued research. Five common African vegetables—Murraya koenigii, Ocimum gratissimum, Amaranthus hybridus, Capsicum annuum and Moringa oleifera were used to study absorption of Lead, Cadmium, Cobalt and Zinc from soils inoculated with metal ions. 0.1 M and 0.5 M solutions of the metal ions were used in the inoculation. Each of the plants was collected in the first instance at 8 weeks, and then at 10 weeks of inoculating. Atomic Absorption spectrophotometer was used to determine the metal ions concentrations absorbed in the plants. Cd2+ was most and Moringa oleifera the least absorbed of the four metal ions, with a highest value of 34.801 ± 0.805 mg/kg occurring in Capsicum annuum. Co2+ was the least absorbed of the four metal ions, Amaranthus hybridus showed highest absorption of Co2+ with mean absorption values of 5.566 ± 0.324 mg/kg and 5.670 ± 0.210 mg/kg for 0.1 M and 0.5 M solution of Co2+ respectively. Ocimum gratissimum absorbed Pb2+ most with the highest mean absorption of 5.290 ± 0.180 mg/kg and 6.354 ± 0.366 mg/kg for 0.1 M and 0.5 M respectively. Absorption increased as the concentration of the inoculant solution increased for all the plants, and decreased on moving from 8 weeks’ to 10 weeks’ for all the plants except Moringa oleifera. This could as a result of Phytovolatilization against the report of Padmavathiamma and Li, 2007 [1] that phytovolatilization occurs in As, Hg and Se. Ocimum gratissimum showed highest absorption with the mean value of 9.334 ± 0.312 mg/kg, when the inoculants concentration increased to 0.5 M, Capsicum annuum showed highest absorption with mean absorption value of 9.916 ± 0.614 mg/kg at 10th week. Also absorption increased as the concentration of the inoculant solution increased, and also on moving from 8 weeks’ to 10 weeks’ for all the plants. From th

关键词： Heavy Metals Ocimum gratissimum Murraya koenigii Capsicum annuum Amaranthus hybridus Moringa oleifera

Comparative study on some selected species of Ocimumgenus on free radical scavenging activity and hepatoprotective activity against CCl4 induced intoxication in rats

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American Journal of Molecular Biology 2013年第4期3卷 183-186页

作者： Myron Green Rajeswara Rao Pragada Sambasivarao Ethadi Bettaiya Rajanna Alcorn State University Mississippi USA AU College of Pharmaceutical Sciences Andhra University Visakhapatnam India

In this study, we compared the in vitro antioxidant property among the selected Ocimum species (O. sanctum, O. americanum, O. basilicum and O. gratissimum) and hepatoprotective activities of their extracts against CCl4 induced intoxication. The results suggested that the four species of Ocimum genus showed variability in Phenolic content and in vitro antioxi-dant activity against DPPH, superoxide and hydroxyl radicals in the following manner: O. sanctum > O. americanum > O. basilicum > O. gratissimum respec-tively. Based on serum AST, ALT, ALP and T. Bil levels, the alcoholic extracts of Ocimum species showed a significant dose dependent (250 mg and 500 mg and 750 mg/kg p.o.) and a protective effect against CCl4 induced hepatotoxicity in albino rats. The results further revealed that the potential hepatoprotective activity of Ocimum sanctum among the Ocimum species.

关键词： Ocimum sanctum Ocimum americanum Ocimum basilicum Ocimum gratissimum Antioxidant Activity Carbon Tetrachloride Hepatotoxicity