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Propylthiouracil induced anti-neutrophil cytoplasmic antibody-associated vasculitis with bone marrow plasmacytosis and granulocytopenia

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Chinese Medical Journal 2009年第9期122卷 1112-1114页

作者： Abdullah Ozkok Department of Internal Medicine University of Istanbul 34390 Fatih/Istanbul Turkey

Antithyroid drugs are molecules known as thionamides that inhibit thyroid hormone synthesis by interfering with thyroid peroxidase mediated iodination of tyrosine residues in thyroglobulin. These extensively used drugs are associated with a variety of well-known side effects such as anti-neutrophil cytoplasmic antibody （ANCA）-positive vasculitis, granulocytopenia and aplastic anemia. Recently, an atypical hematological finding -- bone marrow plasmacytosis, related to the use of methimazole -- was reported twice in English literatures, but bone marrow plasmacytosis with the use of propylthiouracil （PTU） has hardly been reported so far. Herein we present a case of a patient with Graves＇ disease who was initially investigated for plasma cell dyscrasia but finally diagnosed as PTU-induced bone marrow plasmacytosis with granulocytopenia and ANCA-associated vasculitis.

关键词： propylthiouracil anti-neutrophil cytoplasmic antibody-associated vasculitis plasmacytosis granulocytopenia

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Hematopoietic stem cells in research and clinical applications:The“CD34 issue”

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World Journal of Stem Cells 2010年第2期2卷 18-23页

作者： Zoran Ivanovic Etablissement Franais du Sang AquitaineLimousin Place Amélie Raba LéonBP2433035 Bordeaux CedexFrance

In this paper,experimental findings concerning the kinetics of hematopoietic reconstitution are compared to corresponding clinical *** not clearly apparent,the transplantation practice seems to confirm the basic proposals of experimental hematology concerning hematopoietic reconstitution resulting from successive waves of repopulation stemming from different subpopulations of progenitor and stem *** of the "f irst rate" parameters in clinical transplantations in hematology;*** CD34+ positive cell dose,has been discussed with respect to the functional heterogeneity and variability of cell populations endowed by expression of *** parameter is useful only if the relative proportion of stem and progenitor cells in the CD34+ cell population is more or less maintained in a series of patients or *** proportion could vary with respect to the source,pathology,treatment,processing procedure,the graft ex vivo treatment and so ***,a universal dose of CD34+ cells cannot be def *** addition,to avoid further confusion,the CD34+ cells should not be named "stem cells" or "progenitor cells" since these denominations only concern functionally characterized cell entities.

关键词： Hematopoietic progenitors Transplantation Hematopoietic stem cells Hematopoietic reconstitution granulocytopenia CD34+ Functional stem cell def inition Immunophenotype

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