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Influence of granulocyte-macrophage colonystimulating factor and tumor necrosis factor on anti-hepatoma activities of human dendritic cells

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World Journal of Gastroenterology 2000年第5期6卷 718-720页

作者： Jin Kun Zhang Jin Lun Sun Hai Bin Chen Yang Zeng Yao Jun Qu Cencer Pathology Laboratory Shantou University Medical CollegeShantou 515031Guangdong ProvinceChina Department of Allergy Peking Union Medical College HospitalBeijing 100730China

INTRODUCTIONDendritic cells (DCs) play a key regulatory role inantitumor immunity,especially in its immuneaccessory role via MHC-Ⅰ *** haverecently reported that DCs were able to enhance thekilling activity of Lymphokine and PHA activatedkiller (LPAK) cells in *** the presentstudy,we evaluated the effects of GM-CSF andTNF upon antitumor activities of freshly

关键词： dendritic cells granulocytemacrophage colony-stimulating factor tumor necrosis factor anti-hepatoma cell activities in vitro peripheral blood

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Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease

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World Journal of Gastroenterology 2018年第5期24卷 623-630页

作者： Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li Department of Pediatrics Division of Pediatric Gastroenterology Stony Brook University Department of Medicine Division of Gastroenterology Stony Brook University Department of Pediatrics Cincinnati Children’s Hospital Medical Center Department of Medicine Washington University St.Louis Applied Mathematics and Statistics Stony Brook University

AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical *** Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior.

关键词： Inflammatory bowel disease granulocytemacrophage colony-stimulating factor antibody Crohn’s disease surgery

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Preclinical evaluation of herpes simplex virus armed with granulocyte-macrophage colony-stimulating factor in pancreatic carcinoma

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World Journal of Gastroenterology 2013年第31期19卷 5138-5143页

作者： Hao Liu Shou-Jun Yuan Ying-Tai Chen Yi-Bin Xie Liang Cui Wei-Zhi Yang De-Xuan Yang Yan-Tao Tian Department of Abdominal Surgery Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Pharmacological and Toxi-cological Laboratory Institute of Radiation Medicine Medical Radiobiology Laboratory Cancer Hospital Chinese Academy of Medical Science Peking Union Medical College

AIM: To investigate the therapeutic efficacy and mechanisms of action of oncolytic-herpes-simplex-virus encoding granulocyte-macrophage colony-stimulating factor(HSVGM-CSF) in pancreatic ***: Tumor blocks were homogenized in a sterile grinder in *** homogenate was injected into the right armpit of each *** vaccination,the mice were randomly assigned into four groups: a control group,a high dose HSVGM-CSFgroup [1 × 107plaque forming units(pfu)/tumor],a medium dose HSVGM-CSF group(5 × 106pfu/tumor) and a low dose HSVGM-CSF group(5 × 105pfu/tumor).After initiation of drug administration,body weights and tumor diameters were measured every 3 *** days later,after decapitation of the animal by cervical dislocation,each tumor was isolated,weighed and stored in 10% formaldehyde *** drug effectiveness was evaluated according to the weight,volume and relative volume change of each ***,GM-CSF protein levels in serum were assayed by enzyme-linked immunosorbent assays at 1,2,3 and 4 d after injection of ***: Injection of the recombinant mouse HSV encoding GM-CSF resulted in a significant reduction in tumor growth compared to the control group,and dosedependent effects were observed: the relative tumor proliferation rates of the low dose,medium dose and high dose groups on 15 d after injection were 45.5%,55.2% and 65.5%,*** inhibition rates of the tumor weights of the low,middle,and high dose groups were 41.4%,46.7% and 50.5%,***,the production of GM-CSF was significantly increased in the mice infected with *** increase in the GM-CSF level was more pronounced in the high dose group compared to the other two dose ***: Our study provides the first evidence that HSVGM-CSFcould inhibit the growth of pancreatic *** enhanced GM-CSF expression might be responsible for the phenomenon.

关键词： Pancreatic carcinoma Gene therapy Animal test Herpes-simplex-virus encoding granulocytemacrophage colony-stimulating factor

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