检索结果-南通市图书馆

Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy

引用

World Journal of Clinical Cases 2022年第23期10卷 8205-8211页

作者： Bing Yang Xiao-Hong Zhao Guo-Bin Ma Department of Endocrinology and Metabolism 3201 HospitalXi’an Jiaotong University Health Science CenterHanzhong 723099Shaanxi ProvinceChina

BACKGROUND Diabetic nephropathy(DN)is a common complication of type 1 and type 2 diabetes that can lead to kidney damage and high blood *** evidence support the important roles of microproteins and cytokines,such asβ2-microglobulin(β2-MG),glycosylated hemoglobin(HbA1c),and vascular endothelial growth factor(VEGF),in the pathogenesis of this *** this study,we identified novel therapeutic options for this *** To analyze the guiding significance ofβ2-MG,HbA1c,and VEGF levels in patients with *** A total of 107 patients with type 2 diabetes mellitus complicated with nephropathy and treated in our hospital from May 2018 to February 2021 were included in the ***,107 healthy individuals and 107 patients with simple diabetes mellitus were selected as the control *** inβ2-MG,HbA1c,and VEGF levels in the three groups as well as the different proteinuria exhibited by the three groups were *** Changes inβ2-MG,HbA1c,and VEGF levels in the disease,healthy,and simple diabetes groups were significantly different(P<0.05).The expression of these factors from high to low were evaluated in different groups by pairwise *** the disease group,high to low changes inβ2-MG,HbA1c,and VEGF levels were noted in the massive proteinuria,microproteinuria,and normal urinary protein groups,*** in these factors were positively correlated with disease *** The expression of serumβ2-MG,HbA1c,and VEGF was closely correlated with DN progression,and disease progression could be evaluated by these factors.

关键词： Type 2 diabetic nephropathy β2-microglobulin glycosylated hemoglobin Vascular endothelial growth factor Disease progression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of periodontal treatment on glycosylated hemoglobin levels n elderly patients with periodontal disease and type 2 diabetes

引用

Chinese Medical Journal 2011年第19期124卷 3070-3073页

作者： OU Long LI Ru-fan Department of Periodontology General Hospital of People＇s Liberation Army Postgraduate Medical School Beijing 100853 China

Background Periodontal disease is closely related to type 2 diabetes and is an important complication of *** study aimed to investigate the effect of periodontal treatment on levels of blood glucose （Glu） and glycosylated hemoglobin （HbA1c） among elderly patients with type 2 diabetes and periodontal *** A total of 107 elderly patients with type 2 diabetes and periodontal disease were selected and divided into two groups according to their HbA1c levels. Group A was a well-controlled diabetic group and group B was *** probing depth （PD）, attachment loss （AL）, the value of Glu and HbA1c were analyzed before periodontal treatment and 4 months *** There was a significant difference in periodontal condition between groups A and B （P 〈0.01）. The periodontal condition for both groups was significantly （P〈0.01） improved after periodontal therapy. The effect of treatment in group A was more pronounced than group B, and the difference was significant （P 〈0.01）. After the periodontal treatment, Glu and HbA1c were reduced significantly in both groups （P 〈0.05）.Conclusions Periodontal condition is related to the control of Glu level among elderly patients with type 2 diabetes and periodontal disease. Periodontal treatment can effectively reduce the level of Glu and HbA1c as well as improve the periodontal condition in elderly type-2 diabetes patients with periodontal disease.

关键词： periodontal disease type 2 diabetes glycosylated hemoglobin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of Dietary Pattern during Pregnancy and Gestational Diabetes Mellitus： A Prospective Cohort Study in Northern China

引用

Biomedical and Environmental Sciences 2017年第12期30卷 887-897页

作者： DU Hong Yi JIANG Hong O Karmin CHEN Bo XU Lin Ji LIU Shu Ping YI Jian Ping HE Geng Sheng QIAN Xu Department of Maternal Child and Adolescent Health School of Public Health Key Laboratory of Public Health Safety Ministry of Education Fudan University Shanghai 200032 China Department of Animal Science Department of Physiology and Pathophysiology University of Manitoba Winnipeg R3T 2N2 Manitoba Canada Department of Nutrition and Food Hygiene School of Public Health Key Laboratory of Public Health Safety Ministry of Education Fudan University Shanghai 200032 China Maternal and Child Health Care Hospital Tangshan Municipality Tangshan 063000 Hebei China

Objective To examine the association of maternal dietary patterns during pregnancy with gestationa diabetes mellitus （GDM） in northern China. Methods The dietary intakes of pregnant women were recorded twice by 24-hour dietary recalls for three days prior to having been diagnosed with GDM, at 5-15 and 24-28 gestational weeks, respectively. GDM was diagnosed, and serum glycosylated hemoglobin （HbAlc） was measured at 24-28 weeks. Dietary patterns were assessed by factor analysis. The association of the dietary pattern with GDM and HbAlc was examined by multiple logistic models. Results Of 753 participants, 64 （8.5%） were diagnosed with GDM. Four dietary patterns were identified： Western pattern （dairy, baked/fried food and white meat）, traditional pattern （light-colored vegetables, fine grain, red meat and tubers）, mixed pattern （edible fungi, shrimp/shellfish and red meat） and prudent pattern （dark-colored vegetables and deep-sea fish）. Compared with the prudent pattern, both the Western pattern and the traditional pattern were associated with an increased risk of GDM （aOR = 4.40, 95% CI： 1.58-12.22; aOR = 4.88, 95% Ch 1.79-13.32） and a high level of HbAlc （aOR = 12.37, 95% Ch 1.47-103.91; aOR = 26.23, 95% CI： 2.54-270.74）. Compared to the lowest quartile （Q）, 0.3 of the Western pattern scores and Q3-Q4 of the traditional pattern scores were associated with a higher risk of GDM. Conclusion The consumption of the Western pattern or the traditional pattern during pregnancy may increase the risk of GDM.

关键词： Gestational diabetes meltitus Dietary pattern Pregnant women glycosylated hemoglobin Factor analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impairment of gastrointestinal quality of life in severely obese patients

引用

World Journal of Gastroenterology 2014年第22期20卷 7027-7033页

作者： Po-Jui Yu Ju-Juin Tsou Wei-Jei Lee Kuo-Ting Lee Yi-Chih Lee Department of Nursing National Taiwan University Department of Surgery Min-Sheng General Hospital Department of Surgery National Cheng-Kung University Hospiyal Department of International Business Chien Hsin University of Science and Technology

AIM: To investigate the common gastro-intestinal symptoms and quality of life in severely obese subjects.

关键词： Severe obesity Quality of life Gastro-intestinal symptoms glycosylated hemoglobin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of iris volume in glaucoma patients with type 2 diabetes mellitus by AS-OCT

引用

International Journal of Ophthalmology(English edition) 2023年第5期16卷 743-747页

作者： Ying Su Qing-Shu Ge Zong-Yi Li Qian-Wen Bu Die Hu Long-Fang Zhou Xiao-Jing Pan School of Clinical Medicine Weifang Medical UniversityWeifang 261021Shandong ProvinceChina Eye Institute of Shandong First Medical University Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071Shandong ProvinceChina School of Ophthalmology Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina

AIM:To examine the change of iris volume measured by CASIA2 anterior segment optical coherence tomography(ASOCT)in glaucoma patients with or without type 2 diabetes mellitus(T2DM)and explore if there is a correlation between hemoglobin A1c(HbA1c)level and iris ***:In a cross-sectional study,72 patients(115 eyes)were divided into two groups:primary open angle glaucoma(POAG)group(55 eyes)and primary angle-closure glaucoma(PACG)group(60 eyes).Patients in each group were separately classified into patients with or without *** volume and glycosylated HbA1c level were measured and ***:In the PACG group,diabetic patients'iris volume was significantly lower than those of non-diabetics(P=0.02),and there was a significant correlation between iris volume and HbA1c level in the PACG group(r=-0.26,P=0.04).However,diabetic POAG patients'iris volume was noticeably higher than those of non-diabetics(P=0.01),and there was a significant correlation between HbA1c level and iris volume(r=0.32,P=0.02).CONCLUSION:Diabetes mellitus impact iris volume size,as seen by increased iris volume in the POAG group and decreased iris volume in the PACG *** addition,iris volume is significantly correlated with HbA1c level in glaucoma *** findings imply that T2DM may compromise iris ultrastructure in glaucoma patients.

关键词： glaucoma diabetes mellitus iris volume glycosylated hemoglobin optical coherence tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serum tumor markers expression(CA199,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus

引用

World Journal of Diabetes 2024年第2期15卷 232-239页

作者： Mei Meng Li-Li Shi Department of Endocrinology Hefei BOE HospitalHefei 230013Anhui ProvinceChina Department of Cadre Ward The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus(T2DM)is associated with the levels of serum tumor markers of the digestive tract,such as cancer antigen(CA)***,tumor markers in T2DM are *** To evaluate the expression of serum tumor markers[CA199,CA242,and carcinoembryonic antigen(CEA)]and the clinical implications of the expression in *** For this observational study conducted at Hefei BOE Hospital,China,we enrolled 82 patients with first-onset T2DM and 51 controls between April 2019 and December *** of fasting blood glucose(FBG),tumor markers(CA199,CEA,and CA242),glycosylated hemoglobin(HbA1c),*** measured and group index levels were ***,FBG and HbA1c levels were correlated with tumor marker *** markers were tested for diagnostic accuracy in patients with>9%HbA1c using the receiver operating curve(ROC)*** The T2DM group had high serum FBG,HbA1c,CA199,and CEA levels(P9%)revealed significant differences in CEA and CA199 levels(P<0.05).The areas under the ROC curve for CEA and CA199 were 0.853 and 0.809,***199,CEA,and CA242 levels positively correlated with HbA1c(r=0.308,0.426,and 0.551,respectively)and FBG levels(r=0.236,0.231,and 0.298,respectively).CONCLUSION As compared to controls,serum CEA and CA199 levels were higher in patients with ***1c and FBG levels correlated with CA199,CEA,and CA242 *** with poorly controlled blood sugar must be screened for tumor markers.

关键词： Type 2 diabetes mellitus Carcinoembryonic antigen Cancer antigen 199 Cancer antigen 242 glycosylated hemoglobin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prognostic Significance of HbA1c Level in Asian Patients with Prediabetes and Coronary Artery Disease

引用

Cardiovascular Innovations and Applications 2022年第1期6卷 147-160页

作者： Yang Liu Xunxun Feng Jiaqi Yang Tienan Sun Guangyao Zhai Qianyun Guo Yujie Zhou Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

Background:Measuring glycosylated hemoglobin(HbA1c)is a simple way to assess patients with prediabetes or diabetes *** has been shown that HbA1c level predicts prognosis in patients with coronary artery disease(CAD)and the incidence of diabetes ***,the prognostic significance of HbA1c level in Asian patients with prediabetes and CAD is not yet *** study aimed to determine the relationship between HbA1c level and major adverse cardiovascular events(MACE)in patients with prediabetes and ***:We enrolled 1367 patients with prediabetes and CAD in the final analysis,and grouped them according to the HbA1c *** end points included nonfatal myocardial infarction,hospitalization for unstable angina,and ischemia-driven *** proportional-hazards regression analysis was used to determine the relation-ship between HbA1c level and MACE after our accounting for confounding ***:A total of 1367 patients(age 58.8±10.3 years;71.6%men)were *** 43 months of follow-up,197 patients experienced at least one primary end point *** Cox proportional-hazards regression analy-sis showed in comparison of HbA1c levels that the hazard ratio for primary end points was 4.110,with a 95%confidence interval of 2.097-6.011(P<0.001).Conclusions:HbA1c level positively correlated with MACE,demonstrating it is a valuable indicator for indepen-dently predicting MACE in Asian patients with prediabetes and CAD.

关键词： glycosylated hemoglobin adverse cardiovascular outcomes prediabetes coronary artery disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interaction of sleep quality and sleep duration on glycemic control in patients with type 2 diabetes mellitus

引用

Chinese Medical Journal 2014年第20期127卷 3543-3547页

作者： Tang Yunzhao Meng lingling Li Daiqing Yang Min Zhu Yanjuan Li Chenguang Jiang Zhenhuan Yu Ping Li Zhu Song Hongna Ni Changlin Key Laboratory of Hormones and Development (Ministry of Health) Metabolic Diseases Hospital & Tianjin Institute of EndocrinologyTianjin Medical University Yianjin 300070 China

Background Copious evidence from epidemiological and laboratory studies has revealed that sleep status is associated with glucose intolerance, insulin resistance, thus increasing the risk of developing type 2 diabetes. The aim of this study was to reveal the interaction of sleep quality and sleep quantity on glycemic control in patients with type 2 diabetes mellitus. Methods From May 2013 to May 2014, a total of 551 type 2 diabetes patients in Tianjin Metabolic Diseases Hospital were enrolled. Blood samples were taken to measure glycosylated hemoglobin （HbAlc）, and all the patients completed the Chinese version of the Pittsburgh Sleep Quality Index （PSQI） questionnaire to evaluate their sleep status. ＂Good sleep quality＂ was defined as PQSI 〈5, ＂average sleep quality＂ was defined as PQSI 6-8, and ＂poor sleep quality＂ was defined as PQSI 〉8. Poor glycemic control was defined as HbAlc 〉7%. Sleep quantity was categorized as 〈6, 6-8, and 〉8 hours/ night. Short sleep time was defined as sleep duration 〈6 hours/night. Results In the poor glycemic control group, the rate of patients who had insufficient sleep was much higher than that in the other group （X2=11.16, P=0.037）. The rate of poor sleep quality in poor glycemic control group was much greater than that in the average control group （X2=9.79, P=-0.007）. After adjusted by gender, age, body mass index, and disease duration, the adjusted PSQI score＇s OR was 1.048 （95% CI 1.007-1.092, P=0.023） for HbAlc level. The sleep duration＇s OR was 0.464 （95% CI 0.236-0.912, P=0.026） for HbAlc level. One-way analysis of variance showed that the poor sleep quality group had the highest homeostasis model assessment-insulin resistance （P 〈0.01）. Conclusions Inadequate sleep, in both quality and quantity, should be regarded as a plausible risk factor for glycemic control in type 2 diabetes. Poor sleep might bring much more serious insulin resistance and could be the reason for bad glycemic control. A good night＇s sleep should be seen

关键词： diabetes mellitus glycosylated hemoglobin Pittsburgh Sleep Quality Index glycemic control sleep quality sleep quantity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy and safety of saxagliptin in patients with type 2 diabetes mellitus:a meta-analysis of randomized controlled trials

引用

Journal of Chinese Pharmaceutical Sciences 2016年第2期25卷 128-139页

作者：姚莉范芳芳胡兰赵生俊郑丽丽新疆医科大学附属中医医院药学部新疆乌鲁木齐830000

As a new oral hypoglycemic agent, saxagliptin belongs to the class of dipeptidyl peptidase-4 （DPP-4） inhibitors. However, it remains inconclusive whether saxagliptin is associated with increased risk of adverse events （AE） and efficacy as add-on treatment. Therefore, we performed an up-to-date meta-analysis to compare the efficacy and safety of saxagliptin with placebo and other oral hypoglycemic agents in adult patients with type 2 diabetes mellitus （T2DM）. Randomized clinical trials （RCTs） comparing saxagliptin with comparators were retrieved by selecting articles from Pubmed, Embase, Cochrane Library and Clinical Trials Registry Platform up to Oct. 2013. Weighted mean difference （WMD） was used to analyze the effect of hypoglycemic agents on HbAlc, weight and fasting plasma glucose （FPG）. While the patients who achieved HbAlc〈7.0% and had AE were analyzed as relative risks （RR）. A total of 18 articles from 16 RCTs and one clinic trial from the WHO International Clinical Trials Registry Platform met the included criterion. Clinically significant decrease from baseline HbAlc compared with placebo was certified for 2.5 mg/day saxagliptin （WMD = -0.45%, 95% CI, -0.48% to -0.42%） and 5 mg/d saxagliptin （WMD = -0.52%, 95% CI, -0.60% to -0.44%）. Saxagliptin as add-on therapy was superior to thiazolidinediones, up-titrated glyburide, up-titrated metformin or metformin monotherapy in achieving HbA1c〈7.0%. Treatment with saxagliptin had negligible effect on weight, and it was considered weight neutral. Saxagliptin treatment did not increase the risk of hypoglycemia （RR = 1.28, 95% CI 0.72 to 2.27, P = 0.40） and serious adverse experiences （RR = 1.25, 95% CI 0.94 to 1.66, P = 0.13）. No statistically significant differences were observed between saxagliptin and comparators in terms of the risk of infections. The present study showed that saxagliptin was effective in improving glycaemic control in T2DM with a low risk of hypoglycaemia and incidence of infections in either mono

关键词： DPP-4 inhibitor Saxagliptin Meta-analysis Type 2 diabetes mellitus Fasting plasma glucose glycosylated hemoglobin Randomized controlled trial Hypoglycaemia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Utility of a hemoglobin A1C obtained at the first prenatal visit

引用

World Journal of Obstetrics and Gynecology 2014年第3期3卷 130-133页

作者： Lisa E Moore Diana Clokey Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine University of New Mexico

AIM： To evaluate the utility of the hemoglobin A1C （HbA1C） at the frst prenatal visit as a triaging tool in patients at high risk for gestational diabetes （GDM）.METHODS： The HbA1C was obtained at the frst prenatal visit prior to 20 wk. Women with a HbA1C ≥ 6.5% （group one） were instructed on diet and daily self-monitoring of blood glucose. Women with a HbA1C between 5.7%-6.4% （group two） were offered testing or daily self-monitoring of blood glucose. Women with a HbA1C 〈 5.7% （group three） were tested at 24-28 wk. Patients were tested for GDM using the two step testing and Carpenter and Coustan values as cutoffs. Medication was started if patients failed to meet glycemic goals of fasting ≤ 95 mg/dL （5.3 mmol/L） and 2 h postprandial ≤ 120 mg/dL （6.7 mmol/L）.RESULTS： In group one （n = 16）, 15/16 （95%） re-quired medication to achieve euglycemia. The mean gestational age at which medication was required was early at 14 ± 6 wk. Postpartum, 14/16 patients （87%） remained diabetic. Group two contained 82 patients. Sixty-sixpatients （80%） were given a diagnosis of GDM and 52 patients （64%） required medication. The mean gestational age at which medication was started in group two was 20 ± 7.8 wk. There were 205 patients in group three, 18 patients （8.7%） were diagnosed with GDM and 13 patients （6%） required medication. In comparison to group three, patients in group one were 220 times more likely to require medication （95%CI： 26.9- 〉 999, P 〈 0.0001）. Patients in group two were 26 times more likely to require medication （95%CI： 12.5-54.3, P 〈 0.0001）.

关键词： Gestational diabetes Pregnancy Hemoglo-bin A1C glycosylated hemoglobin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：