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血清糖偶合物(glycoconjugates)在口腔癌及癌前病变中的作用

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国际口腔医学杂志 1992年第2期 124-124页

作者：刘春华

哺乳动物细胞的任何特征包括恶性细胞和正常细胞的不同特征都在细胞表面得到表达,肿瘤细胞表面特征的改变是肿瘤细胞异常生长和恶性行为的基础。糖蛋白及糖脂构成细胞膜的主要成份,所以,细胞表面的糖偶合物在恶变中具有重要性,这些糖偶... 详细信息

哺乳动物细胞的任何特征包括恶性细胞和正常细胞的不同特征都在细胞表面得到表达,肿瘤细胞表面特征的改变是肿瘤细胞异常生长和恶性行为的基础。糖蛋白及糖脂构成细胞膜的主要成份,所以,细胞表面的糖偶合物在恶变中具有重要性,这些糖偶合物通过增加流动、分泌和(或)从肿瘤细胞表面释放进入血循环中. 已测出各种恶性肿瘤患者的血清或血浆中的糖偶合物如总唾液酸、脂结合唾液酸、粘蛋白和蛋白结合己糖的水平提高,表明它们在诊断或监控治疗上是有作用

关键词：偶合物 glycoconjugates 癌前病变口腔癌血清糖

Synthesis and immunological study of a glycosylated wall teichoic acid-based vaccine against Staphylococcus aureus

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Chinese Chemical Letters 2023年第4期34卷 193-197页

作者： Peng Shen Han Lin Yikai Bao Haofei Hong Zhimeng Wu Key Laboratory of Carbohydrate Chemistry&Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China

Staphylococcus aureus wall teichoic acids(WTAs) are attractive targets for antibacterial vaccine development. In this study, three core glycosylated WTA structure, including α-1,4-Glc NAc, β-1,4-Glc NAc andβ-1,3-Glc NAc modified ribitol phosphates containing a linker are chemically synthesized and conjugated with tetanus toxin(TT) carrier protein as vaccine candidates. In vivo immunological studies demonstrate that the synthesized glycosylated WTAs display high immunogenicity and all conjugates provoke strong immune responses and elicit high levels of specific IgG antibodies against the Glc NAc-modified WTA. Furthermore, antibodies elicited by the vaccine candidates remain the capability to recognize S. aureus cells and display significant opsonophagocytic activity to clear S. aureus. This study demonstrates that the core structure of glycosylated WTAs are effective antigens for constructing anti-S. aureus vaccines to prevent and control S. aureus infections.

关键词： WTAs Staphylococcus aureus GlcNAc modifications glycoconjugates Antibacterial vaccine

Full synthesis and bioactivity evaluation of Tn-RC-529 derivative conjugates as self-adjuvanting cancer vaccines

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Chinese Chemical Letters 2021年第10期32卷 3011-3014页

作者： Lingqiang Gao Qinghai Lian Leilei Ma Shiwei Su Menglan Yang Yuan Fang Zhongqiu Liu Xiang Luo Guochao Liao Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education International Institute for Translational Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou 510006China

A facile and efficient strategy was established for the construction of RC-529 and its *** conjugates of RC-529 derivatives with Tn antigen were synthesized and all elicited strong and T celldependent immune responses in mice without requiring external *** addition,all antisera induced by these conjugates could specifically recognize,bind to and kill Tn-overexpressing cancer ***,RC-529 shows promise as a useful platform for the development of new vaccine carriers with self-adjuvanting properties for the treatment of ***,preliminary structure-activity relationship analysis provides convincing support for further optimization of,and additional investigation into RC-529.

关键词： RC-529 Tn antigen glycoconjugates Cancer vaccines

Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 442-455页

作者： Gokuladhas Krishnan Jayakumar Subramaniyan Pramila Chengalvarayan Subramani Barath Muralidharan Devaki Thiruvengadam Department of Biochemistry University of MadrasGuindy CampusChennai600025TamilnaduIndia Ragalakshmi Engineering College Chennai602105TamilnaduIndia

Liver cancer is the fifth most common cancer and one of the leading causes of death in the world, and second most common cause of death in men. Natural products emerge as the most enduring approaches in the development of anticancer targeting drug. Hesperetin(HP), one of the abundant flavonoids found naturally in citrus fruits, has received considerable attention in anti-cancer promotion and progression. The present study was conducted to decipher the role of 0.5 ml hesperetin conjugated gold nanoparticles(Au-m PEG(5000)-S-HP NPs) during diethylnitrosamine(DEN)-induced hepatocarcinogenesis in male Wistar albino rats and shows the better antioxidant that possesses anti-inflammatory,anti-proliferation and anticarcinogenic properties and may modulate signaling *** confirmation of polymer functionalized gold nanoparticles and drug loaded polymer gold nanoparticles were characterized by HR-TEM with EDAX, and DLS with Zeta potential techniques. The drug encapsulation efficiency and release properties were carried out in PBS at pH 7.4 for Au-mPEG(5000)-S-HP and compared with the control pure hesperetin(HP).Here, we review the role of mast cell counts, tumor necrosis factor alpha(TNF-α), transcription factor nuclear factor-κB(NF-κB), levels of glycoconjugates, proliferating cell nuclear antigen(PCNA) and argyrophilic nucleolar organizing regions, are the master regulator of inflammation and proliferation, in the development of hepatocellular injury, liver fibrosis and HCC. DEN-administered animals showed increased mast cell counts, tumor necrosis factor alpha, transcription factor nuclear factor-κB, glycoconjugates, proliferating cell nuclear antigen, and argyrophilic nucleolar organizing regions. Whereas Au-mPEG(5000)-S-HP NPs supplementation considerably suppressed all the above abnormalities. These results suggest that the Au-m PEG(5000)-S-HP NPs exhibited the better potential anticancer activity by inhibiting cell inflammation and proliferation in DEN-induced h

关键词： Hesperetin Gold nanoparticles Mast cells glycoconjugates TNF-α NF-κB PCNA

Carboxymethyl glycoside lactone(CMGL) synthons:Scope of the method and preliminary results on step growth polymerization of α-azide-ω-alkyne glycomonomers

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Science China Chemistry 2010年第9期53卷 1880-1887页

作者： CHAMBERT Stéphane BERNARD Julien FLEURY Etienne QUENEAU Yves INSA-Lyon Laboratoire de Chimie Organique et Bioorganique Bat.J.Verne 20 Avenue A.Einstein69621 Villeurbanne CedexFrance ICBMS Institut de Chimie et de Biochimie Moléculaires et SupramoléculairesUMR5246 CNRS université de Lyon université Lyon 1 INSA-Lyon CPE-Lyon Bat.Curien 43 Bd du 11 Novembre 1918F 69622 VilleurbanneFrance INSA-LYON IMP1ngénierie des Matériaux Polymères UMR5223 université de Lyon université Claude Bernard Lyon 1F-69621 Villeurbanne CedexFrance

Carboxymethyl glycoside lactones(CMGLs) are bicyclic synthons which open readily for accessing new types of pseudo-glycoconjugates,such as sugar-amino acid hybrids,neoglycolipids,pseudodisaccharides,and membrane imaging *** lactone opening,free OH-2 is available for further functionalization,leading to 1,2-bisfunctionalized *** strategy is illustrated herein with new polymerizable systems of the AB type bearing both azide and alkyne functions prepared from α or β gluco-CMGL *** the reaction of lactones with propargylamine,an azido group was introduced by two different sequences leading to either the 2-manno-azido or the 6-gluco-azido *** capability of these AB monomers to undergo step growth polymerization through copper(I) catalyzed alkyne-azide cycloaddition(CuAAC) and generate glycopolytriazoles was evidenced.

关键词： carbohydrates glycopolymers lactones click chemistry step growth polymerization glycoconjugates azides alkynes Huisgen cycloaddition

Preliminary Study of the Lectin Receptor Expression in Adenocarcinomas of the Gastrointestinal Tract

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Journal of Medical Colleges of PLA(China) 1989年第4期4卷 315-319,385页

作者：张世民吴孟超陈汉张秀忠马大烈舒鸿逵 Institute of Hepatobiliary Surgery Changhai HospitalSecond Military Medical CollegeShanghai Department of Pathology Changhai HospitalSecond Military Medical CollegeShanghai 200433.

Ten cases of gastrointestinal adenocarcinomas were histochemically investigated fortheir lectin receptors by avidin—biotin-peroxidase complex(ABC)*** showed thatgastric adenocarcinomas expressed more types of lectin receptors than large *** rates of Glc/Man-and GlcNAc-specific lectin receptors in these tu-mors were kigher than those of Gal/GalNAc-and Fuc-specific lectin *** the stom-ach to rectum,the spectrum of the lectin receptors in pericarcinomatous tissues graduallychanged from the gastric type to the rectal *** expression of lectin receptors ingustrointestinal adenocarcinomas was obviously different Jrom that in their correspondingpericarcinomatous *** increase and decrease of lectin receptor expression,theappearance and disappearance of some types of lectin receptors as well as the change of thereceptor distribution are indirectly regulated by cellular genome.

关键词： lectin receptors histochemistry glycoconjugates gastrointestine adenocarcinoma