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COMBINED EFFECTS OF SELECTIVE PHOTOTHERMAL THERAPY AND IMMUNOADJUVANT AGAINST STAGE IV BREAST CANCER

Journal of Innovative Optical Health Sciences 2010年第4期3卷 279-284页

作者： XIAOSONG LI TOMAS HODE MARIA C.GUERRA GABRIELA L.FERREL JOHN A.LUNN ORN ADALSTEINSSON ROBERT E.NORDQUIST WEI R.CHEN Department of Oncology the First Affiliated Hospital of Chinese PLA General Hospital Beijing 100048 China Department of Laser Medicine Chinese PLA General Hospital Beijing 100853 China Department of Engineering and Physics University of Central Oklahoma 100 N.University Drive Edmond Oklahoma 73034USA ImmunoPhotonics Inc. 1601 South Providence Road ColumbiaMissouri 65211USA Hospital Nacional Edgardo Rebagliati Martins Av.Edgardo Rebagliati#490—Jesus Maria LimaPeru Collins Ave. P.O.Box N-215 NassauThe Bahamas International Strategic Cancer Alliance 873 E.Baltimore Pike#333 Kennett Square Philadelphia 19348USA

Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer *** immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent *** pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor *** clinical application of LIT in the treatment of melanoma patients has achieved preliminary ***,LIT has been used to treat late-stage breast cancer *** we report for the first time the clinical results of this combination therapy in breast cancer *** LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is *** of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of *** patient achieved complete response;the other achieved partial response at the time of this *** there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.

关键词： Laser immunotherapy near-infrared laser glycated chitosan indocyanine green metastasis cancer stage IV breast cancer patients clinical trials

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Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

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Journal of Innovative Optical Health Sciences 2015年第4期8卷 97-104页

作者： Joseph T.Acquaviva III Cody F.Bahavar Feifan Zhou Xiaosong Li Eric W.Howard Liz C.Bullen Ricardo P.Silvy Wei R.Chen Biophotonics Research Laboratory Center for Interdisciplinary Biomedical Education and Research University of Central Oklahoma EdmondOklahoma 73034USA South West Nano Technologies NormanOklahoma 73071USA Department of Oncology The First Affiliated Hospital of Chinese PLA General Hospital Fucheng Road 51 BeijingP.R.China University of Oklahoma Health Sciences Center 940 Stanton.L.Young Blvd. BMSB Rm.513 Oklahoma City Oklahoma 73104USA

The ideal treatment modality for metastatic cancer would be a local treatment that can destroy primary tumors while inducing an effective systemic anti-tumor *** this end,we de-veloped laser immunotherapy,combining photothermal laser application with an immunoadju-vant for the treatment of metastatic ***,to enhance the selective photothermal effect,we integrated light-absorbing nanomaterials into this innovative ***,we developed an immunologically modified carbon nanotube combining single-walled carbon nanotubes(SWNTs)with the immunoadjuvant glycated chitosan(GC).To determine the ef-fectiveness of laser iradiation,a series of experiments were performed using two different irra-diation durations-5 and 10 *** were inoculated with DMBA-4 cancer cells,a metastatic cancer cell *** treatment group of rats receiving laser irradiation for 10 min had a 50%long-term survival rate without residual primary or metastatic *** treatment group of rats receiving laser irradiation for 5 min had no long-term survivors;all rats died with multiple metastases at several distant ***,Laser+SWNT-GC treatment with 10 min of laser irradiation proved to be efective at reducing tumor size and inducing long-term anti-tumor immunity.

关键词： Anti-tumor immune response laser immunotherapy single-walled carbon nanotubes glycated chitosan laser irradiation

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ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USING A MOUSE MAMMARY TUMOR MODEL

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 49-55页

作者： FEIFAN ZHOU XIAOSONG LI SHENG SONG JOSEPH T.ACQUAVIVA III ROMAN F.WOLF ERIC W.HOWARD WEI R.CHEN MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science South China Normal University Guangzhou P.R.China Department of Oncology The First A±liated Hospital of Chinese PLA General Hospital Beijing 100048 P.R.China Department of Engineering and Physics University of Central Oklahoma Edmond OklahomaUSA Department of Comparative Medicine College of Medicine University of Oklahoma Health Sciences Center 940 S.L.Young Blvd.Oklahoma City OklahomaUSA Department of Cell Biology University of Oklahoma Health Sciences Center 940 S.L.Young Blvd. Oklahoma City OklahomaUSA

Anti-tunor immunological response induced by local intervention is ideal for treatment of metastatic *** immunot herapy was developed to synergize photot hermal interaction with immunological stimulation for cancer *** an infrared laser,indocyanine green(ICG,as a light abeorbing agent),and glycated chitosan(GC,as an immunostimulant),.laser imm unot herapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical *** further understand the mechanism of laser immunotherapy,the efects of laser and GC treatment without specifc enhancement of laser absorption were *** adoptive immunity transfer was perfomed using splenocytes as immune *** cells harvested from tumor-bearing mice treated by laser+GC provided 60%immunity in naive ***,cytotoxicity and TNF-ar secretion by splenocytes from treated mice also indicated that laser+GC induced immunity was *** high level of infiltrating T cells in tumors after laser+GC treatment furt her confirned a specific anti-tumor immune ***,laser+GC could prove to be a promisi ng selective local trea tment modality that induces a systemic anti-tumor response,with appropriate laser parameters and GC doses.

关键词： Laser immunotherapy glycated chitosan anti-tumor immunity metastatic cancers

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Laser Immunotherapy:Novel Modality to Treat Cancer through Specific Antitumor Immune Response

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中国激光 2010年第11期37卷 2698-2702页

作者：李晓松陈伟 Department of Oncology the First Affiliated Hospital of Chinese PLA General Hospital Department of Engineering and Physics University of Central OklahomaEdmond

Treatment of metastatic cancer remains a great challenge and needs novel *** a selective photothermal therapy with an active immunological stimulation,laser immunotherapy(LIT) was developed to induce systemic immune responses through local *** consists of three major components: a near-infrared laser,a light-absorbing agent,and an immunological *** effect relies on two major interactions: a selective photothermal interaction and an active immunological *** selective photothermal interaction can reduce the tumor burden and at the same time release the tumor antigens,which can induce specific antitumor immune *** expression of heat shock protein and the application of immunoadjuvant further enhance the host *** has been proved in pre-clinical studies that LIT could not only eradicate treated local tumors but also regress and eliminate untreated metastases at distant ***,LIT is well tolerated and has shown to have many advantages for cancer treatment compared with other traditional modalities.

关键词： medical optics laser immunotherapy cancer treatment immunoadjuvant cancer vaccine glycated chitosan

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