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Circulating glycated albumin levels and gestational diabetes mellitus

World Journal of Diabetes 2024年第8期15卷 1802-1810页

作者： Wei Xiong Zhao-Hui Zeng Yuan Xu Hui Li Hui Lin Department of Medical Hunan Traditional Chinese Medical CollegeZhuzhou 412012Hunan ProvinceChina Department of Outpatient Zhuzhou Second HospitalZhuzhou 412012Hunan ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)is characterized by glucose intolerance that is first diagnosed during pregnancy,making it the most common complication associated with this *** detection and targeted treatment of GDM can minimize foetal exposure to maternal hyperglycaemia and subsequently reduce the associated adverse pregnancy *** studies have inconsistently suggested that the level of glycated albumin(GA)might predict *** To review and synthesize existing evidence to evaluate the relationship between GA levels and the development of *** We sought to compare GA levels between GDM and control groups in this metaanalysis by systematically searching the Web of Science,PubMed,Cochrane Library,and Embase databases for articles published up to June *** analysis utilized the weighted mean difference(WMD)as the primary *** data were meticulously extracted,and the quality of the included studies was ***,we conducted a subgroup analysis based on study region and sample *** assessed heterogeneity using I2 statistics and evaluated publication bias through funnel ***,trim-and-fill analysis was employed to detect and address any potential publication *** The meta-analysis included a total of 11 studies involving 5477 participants,comprising 1900 patients with GDM and 3577 control *** synthesized results revealed a notable correlation between elevated GA levels and increased susceptibility to *** calculated WMD was 0.42,with a 95%confidence interval(95%CI)ranging from 0.11 to 0.74,yielding a P value less than *** specific GA levels,the mean GA level in the GDM group was 12.6,while for the control group,it was lower,at *** discrepancy underscores the potential of GA as a biomarker for assessing GDM ***,we explored the levels of glycated haemoglobin(HbA1c)in both *** WMD for HbA1c was 0.19,with a 95%CI ranging from 0.15 to 0.

关键词： glycated albumin Gestational diabetes mellitus Diabetes mellitus Meta-analysis Weighted mean difference

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The Use of glycated albumin in the Diagnosis of Gestational Diabetes Mellitus

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Journal of Biosciences and Medicines 2024年第1期12卷 19-28页

作者： Atochi Prince Woruka Celestine Osita John Obstetrics and Gynecology Department University of Port Harcourt Teaching Hospital Port Harcourt Nigeria Obstetrics and Gynecology Department University of Port Harcourt Port Harcourt Nigeria

Gestational diabetes mellitus is the most common endocrine disorder in pregnancy and a cause of maternal and fetal morbidities and mortalities. The oral glucose tolerance test is the gold standard for diagnosing gestational diabetes mellitus. Nevertheless, the oral glucose tolerance test is time-consuming and requires patient preparation. On the contrary, glycated albumin does not require patient preparation or administration of any substance. Most studies on glycated albumin in pregnancy were among the non-African population, and black Americans have higher glycated albumin levels than Caucasians. This study determined the use of glycated albumin in diagnosing gestational diabetes mellitus among pregnant women. The study was a prospective study of 160 pregnant women between 24 and 28 weeks of gestation at the University of Port Harcourt Teaching Hospital. The diagnosis of gestational diabetes mellitus was based on the World Health Organization 2013 criteria. The diagnostic value of glycated albumin was determined using the area under the receiver operator characteristic curve. The prevalence of gestational diabetes mellitus was 9.4% and the mean glycated albumin was 16.91% (±2.77). The area under the receiver operator characteristic curve for glycated albumin was 0.845 (95% CI 0.733 - 0.956;p = 0.0001). The optimal cut-off value of glycated albumin in the diagnosis of gestational diabetes mellitus was 18.9%. glycated albumin was useful in the diagnosis of gestational diabetes mellitus at 24 to 28 weeks of gestation.

关键词： glycated albumin Gestational Diabetes Mellitus Oral Glucose Tolerance Test University of Port Harcourt Teaching Hospital

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Study on the Clinical Application of Nutritional Management Combined with Clinical Monitoring of glycated albumin in Diabetic Nephropathy Dialysis Patients

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Journal of Clinical and Nursing Research 2024年第9期8卷 146-151页

作者： Hongliang Wang Aixin Shen Shanshan Zhang Na Jin People’s Hospital of Guandu District Kunming 650200Yunnan ProvinceChina

Objective:To explore the clinical application of nutritional management combined with clinical monitoring of glycated albumin(GA)in diabetic nephropathy(DN)dialysis ***:A total of 20 diabetic nephropathy dialysis patients admitted to the People’s Hospital of Guandu District from January 2022 to February 2023 were included in the *** were randomly divided into a conventional group(n=10)and an observation group(n=10).The study evaluated the blood glucose control,nutritional status,dialysis efficacy,and quality of life scores of both ***:Before the intervention,there were no significant differences in fasting plasma glucose(FPG),GA,serum albumin,body mass index(BMI),dialysis efficiency values,urea clearance rate,or quality-of-life scores between the two groups(P>0.05).After the intervention,the observation group showed significantly lower FPG and GA levels,higher serum albumin,dialysis efficiency values,urea clearance rate,and improved quality-of-life scores compared to the conventional group(P0.05).Conclusion:Nutritional management combined with clinical monitoring of glycated albumin has a significant effect on the clinical application of diabetic nephropathy dialysis *** can effectively improve patients’blood glucose control and nutritional status,reduce the risk of complications,and enhance the quality of life,demonstrating clinical value for broader application.

关键词： Nutritional management glycated albumin Diabetic nephropathy Dialysis

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glycated albumin may be a choice, but not an alternative marker of glycated hemoglobin for glycemic control assessment in diabetic patients undergoing maintenance hemodialysis

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Chinese Medical Journal 2013年第17期126卷 3295-3300页

作者： CHEN Fengskun SUN Xue-feng ZHANG Dong CUI Shao-yuan CHEN Xiang-mei WEI Ri-bao LU Ju-ming LI Ji-jun LIU Wen-hu ZHANG Dong-liang ZHANG Zhi-min Department of Nephrology First Affiliated Hospital of People's Liberation Army General Hospital Beijing 100048 China Institute of Nephrology People's Liberation Army General Hospital Beijing 100853 China Department of Endocrinology People's Liberation Army General Hospital Beijing 100853 China Department of Nephrology Affiliated Beijing Friendship Hospital of Capital Medical University Beijing 100050 China Department of Nephrology People's Liberation Army the 309th Hospital Beijing 100091 China

Background It has been suggested that glycated hemoglobin （HbAlc） underestimate the actual glycemic control levels in maintenance hemodialysis （MHD） patients, because of anemia and the using of erythropoietin （EPO）; it was recommended that glycated albumin （GA） should be an alternative marker. Therefore, the assessment performances of glycemic control were compared between GA and HbAlc in this research by referring to mean plasma glucose （MPG） in diabetes mellitus （DM） patients undergoing MHD or not. Methods MPG was calculated according to the data registered at enrollment and follow-up 2 months later and corresponding HbAlc, albumin （ALB）, GA, etc. were measured in 280 cases. A case-control study for comparing GA and HbAlc was done among the groups of MHD patients with DM （n=88） and without DM （NDM; n=90）, and non-MHD ones with DM （n=102） using MPG for an actual glycemic control standard. Results In these 3 groups, only for DM patients＇（whether undergoing MHD or not）, GA and HbAlc correlated with MPG significantly （P 〈0.01）. Through linear regression analysis, it could be found that the regression curves of GA almost coincided in MHD and non-MHD patients with DM, because the intercepts （2.418 vs. 2.329） and slopes （0.053 vs. 0.057） were very close to each other. On the contrary, regression curves of HbAlc did not coincide in the two groups, because variance of the slopes （0.036 vs. 0.052） were relatively large. Through comparing receiver operating characteristic （ROC） areas under the curve （AUC）, it could be understood that the assessment performances of GA and HbAlc in MHD patients were lower than those in non-MHD ones, and assessment performance of HbAlc in MHD patients was better than GA （P 〈0.05）. In addition, the effects of Hb and EPO dose on HbAlc, or that of ALB on GA were unobvious in our study. Conclusions Actual glycemic control level in MHD patients with DM may be underestimated by HbAlc, and it could be avoided by GA; however, glycemic evaluating perfo

关键词： maintenance hemodialysis diabetes mellitus glycated albumin glycated hemoglobin

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glycated albumin as a biomarker for diagnosis of diabetes mellitus:A systematic review and meta-analysis

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World Journal of Clinical Cases 2021年第31期9卷 9520-9534页

作者： Jia-Yao Xiong Jun-Mei Wang Xiao-Lan Zhao Chao Yang Xian-Shu Jiang Yan-Mei Chen Chang-Qin Chen Zhi-Yong Li Department of Endocrinology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China

BACKGROUND glycated albumin(GA),the non-enzymatic glycation product of albumin in plasma,became a glycemic marker in the beginning of the 21st *** assay is not affected by hemoglobin levels and reflects the glycemic status over a shorter period as compared to HbA1c ***,GA may contributes as an intermediate glucose index in the current diabetes mellitus(DM)diagnostic *** To search and summarize the available data on glycated albumin measurements required for the diagnosis of diabetes *** Databases,including PubMed,Embase,Web of Science,and Cochrane Central Register of Controlled Trials(CENTRAL),among others,were systematically *** Quality Assessment of Diagnostic Accuracy Studies-2 tool was applied for the assessment of quality,and the bivariate model was used to pool the sensitivity and *** hierarchical summary receiver operator characteristic curves(HSROC)model was utilized to estimate the summary receiver operating characteristics curve(SROC).Sensitivity analysis was performed to investigate the association of the study design and patient characteristics with the test accuracy and meta-regression to find the source of *** Three studies regarding gestational diabetes mellitus(GDM)and a meta-analysis of 16 non-GDM studies,comprising a total sample size of 12876,were included in the *** reveal that the average cut-off values of GA reported for the diagnosis of GDM diagnosis was much lower than those for *** non-GDM cases,diagnosing DM with a circulating GA cut-off of 14.0%had a sensitivity of 0.766(95%CI:0.539,0.901),specificity of 0.687(95%CI:0.364,0.894),and area under the curve of 0.80(95%CI:0.76,0.83)for the *** estimated SROC at different GA cut-off values for non-GDM exhibited that the average location parameter lambda of 16 non-GDM studies was 2.354(95%CI:2.002,2.707),and the scale parameter beta was-0.163(95%CI:-0.614,0.288).These non-GDM studies with variou

关键词： glycated albumin Diabetes mellitus Diagnosis Sensitivity and Specificity Systematic review Meta-analysis

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Use of glycated albumin for the identification of diabetes in subjects from northeast China

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World Journal of Diabetes 2021年第2期12卷 149-157页

作者： Guo-Yan Li Hao-Yu Li Qiang Li Department of Endocrinology and Metabolism The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150080Heilongjiang ProvinceChina Faculty of Population Health Sciences University College LondonLondon WC1E 6BTUnited Kingdom

BACKGROUND Metabolic memory is important for the diagnosis and treatment of diabetes in the early stage,and in maintaining blood glucose concentrations within the normal *** clinical diagnosis of diabetes mellitus is currently made using fasting plasma glucose,2 h-plasma glucose(2h-PG)during a 75 g oral glucose tolerance test,and hemoglobin A1c(HbA1c)***,the fasting plasma glucose test requires fasting,which is a barrier to screening,and reproducibility of the 2h-PG level is ***1c is affected by a shortened red blood cell *** patients with anemia and hemoglobinopathies,the measured HbA1c levels may be *** with HbA1c,glycated albumin(GA)is characterized by more rapid and greater changes,and can be used to diagnose new-onset diabetes especially if urgent early treatment is required,for example in gestational *** this study,we provided cutoff values for GA and evaluated its utility as a screening and diagnostic tool for diabetes in a large high-risk group *** To evaluate the utility of GA in identifying subjects with diabetes in northeast China,and to assess the diagnostic accuracy of the proposed GA cutoff in the diagnosis of diabetes *** This cross-sectional study included 1935 subjects,with suspected diabetes or in high-risk groups,from 2014 to 2015 in the Second Affiliated Hospital of Harbin Medical University(Harbin,China).The use of GA to identify diabetes was investigated using the area under the receiver operating characteristic curve(AUC).The GA cutoffs were derived from different 2h-PG values with hemoglobin A1c cutoffs used as a calibration *** The GA cutoff for the diagnosis of diabetes mellitus was 15.15%from the receiver operating characteristic(ROC)*** analysis demonstrated that GA was an efficient marker for detecting diabetes,with an AUC of 90.3%.CONCLUSION Our study supports the use of GA as a biomarker for the diagnosis of diabetes.

关键词： glycated albumin Receiver operating characteristic Cut-off Hemoglobin A1c Diagnosis Diabetes mellitus

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Carbohydrate Intake Is Correlated with the glycated albumin to glycated Hemoglobin Ratio in Drug-Naive Patients with Type 2 Diabetes

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Journal of Diabetes Mellitus 2016年第1期6卷 10-15页

作者： Satoru Sumitani Yoshihiko Utsu Shuhei Nishina Kenta Okuro Atsushi Kogetsu Seigo Ishii Akiko Deguchi Bunzo Sato Isao Tachibana Soji Kasayama Masafumi Koga Center for Diabetes and Endocrinology Nissay Hospital Osaka Japan Department of Medicine Nissay Hospital Osaka Japan Department of Internal Medicine Kawanishi City Hospital Hyogo Japan

Background: The glycated albumin (GA) to HbA1c ratio (GA/HbA1c ratio) has been reported to reflect postprandial hyperglycemia. Carbohydrate is the primary dietary macronutrient that causes postprandial hyperglycemia. Thus, we investigated whether carbohydrate intake was associated with the GA/HbA1c ratio in patients with type 2 diabetes. Methods: Daily energy intake and carbohydrate intake were estimated in twenty-two patients with type 2 diabetes who received no pharmacological therapy (18 men and 4 women, age 53 ± 11 years old). The energy index and the carbohydrate index were defined as the ratio of daily energy intake to body weight and daily carbohydrate intake to body weight, respectively. Results: The energy index was significantly correlated with the GA/HbA1c ratio (r = 0.451, p = 0.035), but not with fasting plasma glucose (FPG), HbA1c and GA. The carbohydrate index was significantly correlated with GA (r = 0.461, p = 0.031) and the GA/HbA1c ratio (r = 0.554, p = 0.007), but not with FPG and HbA1c. Multivariate analysis revealed that the carbohydrate index was independently associated with the GA/HbA1c ratio (β = 0.397, p = 0.046). Conclusions: The carbohydrate index was significantly correlated with GA and the GA/HbA1c ratio in the patients with type 2 diabetes. These results suggest that carbohydrate intake may be associated with the GA/HbA1c ratio through postprandial hyperglycemia.

关键词： glycated albumin HbA1c Type 2 Diabetes Mellitus Carbohydrate Postprandial Hyperglycemia

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Evaluation of Glucose Metabolism in Acute Myocardial Infarction by glycated albumin and glycated Haemoglobin

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South China Journal of Cardiology 2009年第4期10卷 186-189页

作者：谭虹薛凌周颖玲王娟董豪坚 Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Academy of Medical Sciences Guangdong Provincial People's Hospital

Objectives To detect whether persisting or transient glucose metabolism disorder is responsible for admission hyperglycemia in patients with acute myocardic infarction （AMI）. Methods Two groups of patients were enrolled： AMI group and control group. Fasting plasma glucose, 2 hours plasma glucose, glycated albumin（GA） and glycated haemoglobin （ HbA1 c） were measured at baseline in both groups and 30 days after AMI attack in AMI group. Results （ 1 ） There were no significant differences in baseline characteristics between both groups; （2） Compared with the control group, the levels of GA and HbA1 c in AMI group at baseline were significantly higher. （ 3 ） At 30 day follow-up in AMI group, both FBG and 2hPG decreased to normal values, HbA1 c did not change, but only GA kept on increasing. Conclusions Hyperglycemia on admission in patients with AMI resulted from both preexisting metabolic disorder and stress reaction as well. GA is the only indicator that could recall the exaggeration of glucose metabolic disorder during AMI attack at 30 day follow-up. （ S Chin J Cardiol 2009; 10（4）： 186 -189）

关键词： acute myocardial infarction glycated albumin glycated haemoglobin hyperglycemia

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Update on biomarkers of glycemic control

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World Journal of Diabetes 2019年第1期10卷 1-15页

作者： Maja Krhac Marijana Vucic Lovrencic Division of Laboratory Medicine Department of Medical Biochemistry and Laboratory Medicine Merkur University Hospital

Attaining and maintaining good glycemic control is a cornerstone of diabetes care. The monitoring of glycemic control is currently based on the self-monitoring of blood glucose(SMBG) and laboratory testing for hemoglobin A1 c(HbA1 c),which is a surrogate biochemical marker of the average glycemia level over the previous 2-3 mo period. Although hyperglycemia is a key biochemical feature of diabetes, both the level of and exposure to high glucose, as well as glycemic variability, contribute to the pathogenesis of diabetic complications and follow different patterns in type 1 and type 2 diabetes. HbA1 c provides a valuable,standardized and evidence-based parameter that is relevant for clinical decision making, but several biological and analytical confounders limit its accuracy in reflecting true glycemia. It has become apparent in recent years that other glycated proteins such as fructosamine, glycated albumin, and the nutritional monosaccharide 1,5-anhydroglucitol, as well as integrated measures from direct glucose testing by an SMBG/continuous glucose monitoring system, may provide valuable complementary data, particularly in circumstances when HbA1 c results may be unreliable or are insufficient to assess the risk of adverse outcomes. Long-term associations of these alternative biomarkers of glycemia with the risk of complications need to be investigated in order to provide clinically relevant cut-off values and to validate their utility in diverse populations of diabetes patients.

关键词： Diabetes mellitus Hemoglobin A1c Fructosamine glycated albumin 1,5anhydroglucitol Plasma glucose Glucose variability Diabetic complications

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