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Identification of glutamate transporters and receptors in mouse testis

Acta Pharmacologica Sinica 2004年第3期25卷 112-117页

作者： Jia-hua HU,Na YANG2,Ying-hua MA,Jie JIANG,Jin-fu ZHANG3,Jian FEI4,Li-he GUO4 Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031 3Department of Urology,Tongji Hospital,Tongji University,Shanghai 200065,China 中科院上海生命科学院 Laboratory of Molecular Cell Biology CAS 上海 200031 Department of Urology Tongji Hospital Tongji University 上海 200065

AIM: To investigate the presence of glutamate transporters and receptors in mouse testis. METHODS: Glutamate uptake analysis was performed to study the function of glutamate transporters in mouse testis. Comparative RT-PCR technique and sequencing analysis were used to study the expression of glutamate receptors and transport- ers in mouse testis. RESULTS: Mouse testis possessed glutamate uptake capacity with sodium-dependence. Vmax value of glutamate uptake was (1.60 ± 0.21) pmol/min per mg protein and Km value of glutamate uptake was (11.0±1.6) μmol/L in mouse testis according to saturation analysis. Furthermore, the uptake activity could be inhibited by DHK (GLT1 selective inhibitor) and THA (glutamate uptake inhibitor). In addition, RT-PCR results revealed that glutamate transporters (GLT1 and EAAC1) and ionotropic glutamate receptors (NR1, NR2B, GluR6 and KA2) were expressed in mouse testis. CONCLUSION: Glutamate transporters and receptors do exist in mouse testis.

关键词： glutamates receptors amino acid transport systems testis uptake

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Effect of dipeptide of glutamine and alanine on severe traumatic brain injury

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Chinese Journal of Traumatology 2007年第3期10卷 145-149页

作者：杨德林徐俊法 Department of Neurosurgery Huashan HospitalFudan University Department of Neurosurgery People's Hospital in Pudong New Area

Objective： To determine the effect of dipeptide of glutamine and alanine on patients with severe traumatic brain injury. Methods： A total of 46 patients （31 males and 15 females, aged 7-68 years, （ 47 ± 9. 6 ） years on average ） with severe traumatic brain injury were randomized into two groups： Group G （n=23） and Group C （n =23）. The patients in Group G received nutritional remedy with the dipeptide of glutamine and alanine, whereas the patients in Group C received routine nutritional therapy only. GCS changes, the length of stay in the neurosurgical intensive care unit （NICU）, the mortality, the count of lymphocytes, related complications including lung infection and hemorrhage of alimentary tracts, etc, were examined and recorded. Results： The fatality rate and the length of stay in NICU in Group G was lower than these in Group C （P〈0.05）, but no obvious difference was found in GCS changes of the patients between the two groups （ P 〉 0.05 ）. The patients with lung infection and alimentary tract hemorrhage in Group G were less than those in Group C （P〈0.05）. The count of lymphocytes in Group G was more than that in Group C （P 〈0.05）, but no difference was found in other nutritional data. Conclusions： Dipeptide of glutamine and alanine can increase the resisting stress and anti-infection ability of patients with severe traumatic brain injury, which can also lower the mortality and shorten the NICU stay.

关键词： Brain injuries Dipeptides glutamates Alanine Nutritional therapy

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Protective　Effect　of　Anisodsmine　on　Brain　Edema　Induced　by　Pertussis　Bacilli　in　Rabbits

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Chinese Journal of Integrative Medicine 1997年第1期3卷 51-53页

作者：罗自强岳少杰虞佩兰杨于嘉

Objective: To observe the effect of 654-2 on brain edema model induced by pertussis bacilli in rabbits. Methods: Brain edema model of 26 rabbits induced by pertussis bacilli was prepared for observation,their brain water content and brain glutamate level were determined before and after treatment. Results: 654-2could decline the water content of brain and increase the glutamate level in brain tissue of the treatment group as compared with group without treatment. Conclusion: 654-2 has protective effect on brain edema induced by pertussis bacilli.

关键词： anisodamine bordetella pertussis brain edema models glutamates

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