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Activating transcription factor 3,glucolipid metabolism,and metabolic diseases

Journal of Molecular Cell Biology 2022年第10期14卷 1-10页

作者： Shuwei Hu Xiaojie Zhao Rui Li Chencheng Hu Huĳuan Wu Jing Li Yanqiao Zhang Yanyong Xu Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOH 44272USA Department of Pathology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Endocrinology Beĳing Chao-yang HospitalCapital Medical UniversityBeĳing 100020China Key Laboratory of metabolism and Molecular Medicine of the Ministry of Education Department of Pathology of School of Basic Medical SciencesFudan UniversityShanghai 200032China Frontier Innovation Center School of Basic Medical SciencesFudan UniversityShanghai 200032China

Lipids and glucose exert many essential physiological functions,such as providing raw materials or energy for cellular biosynthesis,regulating cell signal transduction,and maintaining a constant body *** of lipid and glucose metabolism can lead to glucolipid metabolic disorders linked to various metabolic diseases,such as obesity,diabetes,and cardiovascular ***,intervention in glucolipid metabolism is a key therapeutic strategy for the treatment of metabolic *** transcription factor 3(ATF3)is a transcription factor that acts as a hub of the cellular adaptive-response network and plays a pivotal role in the regulation of inflammation,apoptosis,DNA repair,and *** evidence has illustrated the vital roles of ATF3 in glucolipid ***3 inhibits intestinal lipid absorption,enhances hepatic triglyceride hydrolysis and fatty acid oxidation,promotes macrophage reverse cholesterol transport,and attenuates the progression of western diet-induced nonalcoholic fatty liver disease and *** addition to its role in lipid metabolism,ATF3 has also been identified as an important regulator of glucose ***,we summarize the recent advances in the understanding of ATF3,mainly focusing on its role in glucose and lipid metabolism and potential therapeutic implications.

关键词： ATF3 glucolipid metabolism metabolic organ metabolic diseases

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Fluorescent probes for glucolipid metabolism of bacterial cell wall

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Green Chemical Engineering 2023年第4期4卷 417-426页

作者： Yurou Huang Xiaoxie Ma Caimin Gao Yuan Xie Mingqiang Qiu Jun Yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan430079China Guangdong Provincial Key Laboratory of Radioactive and Rare Resource Utilization Shaoguan512026China

Cell wall is a basic component of bacteria that promotes bacteria to adapt the complicated environment as well as play an essential role in antimicrobial *** structure of bacterial cell wall is remarkably rich,and some complex components,such as peptidoglycan,lipopolysaccharide,and peptidoglycan-arabinogalactan et al.,can only be found in ***,the biosynthesis and transfer of these glycolipids are indispensable for bacteria during cell *** the process of biosynthesis and transfer are generally associated with metabolism and sophisticated enzyme ***,how the metabolic process takes place,what role enzymes play in this process and how they function have been major concerns for scientists in this *** significant progresses on fluorescent probes and biological imaging bring opportunity for the studying of metabolism and enzyme mechanisms recently due to its non-invasive and high *** this review,we focused on metabolic fluorescent probes for the detection of glycolipids in bacterial cell wall and highlighted the involving mechanisms and biological application.

关键词： Fluorescent probes Bacteria Cell wall glucolipid metabolism

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Sex-dependent obesogenic effect of tetracycline on Drosophila melanogaster deteriorated by dysrhythmia

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Journal of Environmental Sciences 2023年第2期124卷 472-480页

作者： Xueping Guo Zhenyang Yu Daqiang Yin State Key Laboratory of Pollution Control and Resource Reuse Key Laboratory of Yangtze River Water EnvironmentMinistry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Jiaxing Tongji Institute for Environment Jiaxing 3014051China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Antibiotics have been identified as obesogens contributing to the prevalence of ***,their environmental toxicity shows sex dependence,which might also explain the sex-dependent obesity ***,the direct evidence for such a connection and the underlying mechanisms remain to be *** this study,the effects of tetracycline,which is a representative antibiotic found in both environmental and food samples,on Drosophila melanogaster were studied with consideration of both sex and circadian rhythms(represented by the eclosion rhythm).Results showed that in morning-eclosed adults,tetracycline significantly stimulated the body weight of females(AM females)at 0.1,1.0,10.0 and 100.0μg/L,while tetracycline only stimulated the body weight of males(AM males)at 1.0μg/*** the afternoon-eclosed adults,tetracycline significantly stimulated the body weight of females(PM females)at 0.1,1.0 and 100.0μg/L,while it showed more significant stimulation in males(PM males)at all ***,the stimulation levels were the greatest in PMmales among all the *** results showed the clear sex dependence of the obesogenic effects,which was diminished by *** biochemical assays and clustering analysis suggested that the sex-and rhythm-dependent obesogenic effects resulted from the bias toward lipogenesis against ***,theywere closely related to the preference for the energy storage forms of lactate and glucose and also to the presence of excessive insulin,with the involvement of glucolipid *** relationships indicated potential bridges between the obesogenic effects of pollutants and other diseases,e.g.,cancer and diabetes.

关键词： Obesogenic effect Tetracycline Sex Circadian rhythm glucolipid metabolism

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Dietary fat supplementation relieves cold temperature-induced energy stress through AMPK-mediated mitochondrial homeostasis in pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1669-1687页

作者： Wei He Xinyu Liu Ye Feng Hongwei Ding Haoyang Sun Zhongyu Li Baoming Shi College of Animal Science and Technology Northeast Agricultural University600 Changjiang StreetHarbin 150030PR China

Background Cold stress has negative effects on the growth and health of mammals, and has become a factor restricting livestock development at high latitudes and on plateaus. The gut-liver axis is central to energy metabolism, and the mechanisms by which it regulates host energy metabolism at cold temperatures have rarely been illustrated. In this study, we evaluated the status of glycolipid metabolism and oxidative stress in pigs based on the gut-liver axis and propose that AMP-activated protein kinase(AMPK) is a key target for alleviating energy stress at cold temperatures by dietary fat *** Dietary fat supplementation alleviated the negative effects of cold temperatures on growth performance and digestive enzymes, while hormonal homeostasis was also restored. Moreover, cold temperature exposure increased glucose transport in the jejunum. In contrast, we observed abnormalities in lipid metabolism, which was characterized by the accumulation of bile acids in the ileum and plasma. In addition, the results of the ileal metabolomic analysis were consistent with the energy metabolism measurements in the jejunum, and dietary fat supplementation increased the activity of the mitochondrial respiratory chain and lipid metabolism. As the central nexus of energy metabolism, the state of glycolipid metabolism and oxidative stress in the liver are inconsistent with that in the small intestine. Specifically, we found that cold temperature exposure increased glucose transport in the liver, which fully validates the idea that hormones can act on the liver to regulate glucose output. Additionally, dietary fat supplementation inhibited glucose transport and glycolysis, but increased gluconeogenesis, bile acid cycling, and lipid metabolism. Sustained activation of AMPK, which an energy receptor and regulator, leads to oxidative stress and apoptosis in the liver;dietary fat supplementation alleviates energy stress by reducing AMPK *** Cold s

关键词： Apoptosis Cold temperature Energy stress Fat glucolipid metabolism Mitochondrial homeostasis

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Intrauterine growth retardation affects liver bile acid metabolism in growing pigs:effects associated with the changes of colonic bile acid derivatives

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Journal of Animal Science and Biotechnology 2023年第2期14卷 711-728页

作者： Yang Liu MdAbul Kalam Azad Wanghong Zhang Liang Xiong Francois Blachier Zugong Yu Xiangfeng Kong Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro‑Ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095JiangsuChina UMR PNCA Universite Paris-SaclayINRAE75005 AgroParisTechParisFrance.

Background:Intrauterine growth retardation(IUGR)is associated with severely impaired nutrient metabolism and intestinal development of *** previous study found that IUGR altered intestinal microbiota and metabolites in the ***,the consequences of IUGR on bile acid metabolism in pigs remained *** present study aimed to investigate the bile acid metabolism in the liver and the profile of bile acid derivatives in the colon of grow-ing pigs with IUGR using bile acid targeted ***,we determined correlations between colonic microbiota composition and metabolites of IUGR and normal birth weight(NBW)pigs at different growth stages that were 7,21,and 28-day-old,and the average body weight(BW)of 25,50,and 100 kg of the NBW ***:The results showed that the plasma total bile acid concentration was higher(Pmetabolism(ATGL,HSL,and PC)were down-regulated(Pglucolipid metabolism in growing pigs,especially at th

关键词： Bile acid metabolism glucolipid metabolism Intestinal microbiota Intrauterine growth retardation Pigs

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The impact of the novel starch-lipid complexes on the glucolipids metabolism, inflammation, and gut dysbiosis of type 2 diabetes mellitus rats

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Food Science and Human Wellness 2024年第6期13卷 3210-3223页

作者： Yingshuang Lu Renbing Qin Jin Wang Fengjuan Xiang Yan Zhang Bowei Zhang Dancai Fan Huan Lü Xuemeng Ji Shujun Wang Shuo Wang Tianjin Key Laboratory of Food Science and Health School of MedicineNankai UniversityTianjin 300071China School of Food Science Henan Institute of Science and TechnologyXinxiang 453600China State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China

It has been widely accepted that resistant starch(RS)provides numerous health benefits for *** this research,we aimed at evaluating the performance of novel starch-lipid complexes,RS5,in comparison with RS2 on physical features,glucolipids metabolism,inflammation,and gut microbiota profiles of type 2 diabetes mellitus(T2DM)*** T2DM model was established by streptozotocin injection to the high-fat-sugar fed *** to a serial of biochemical analyses,we found that RS5 diets were strongly correlated with enhanced homeostatic model assessment for insulin secretion(HOMA-IS),high-density lipoprotein cholesterol(HDL-C),adiponectin(ADP),insulin action index(IAI),glucagon-like peptide-1(GLP1),and short-chain fatty acids(SCFAs)in T2DM rats whilst negatively associated with the low-density lipoprotein(LDL-C)and inflammatory cytokines,showing the capabilities to ameliorate T2DM symptoms by regulation of glucolipid metabolism,gut metabolites,and *** the other hand,RS2-enriched supplementations were influential in the mediation of insulin secretion to improve glucose *** increasing evidence collected herein suggested that intestinal microbiota could mediate glucolipids metabolism and alleviate inflammation after certain microflora nourished by *** addition,RS intake made an impact on phosphoinositide 3-kinase/protein kinase B signaling pathway that might contribute to the improvement of glucose metabolism,insulin resistance,and inflammatory responses.

关键词： Resistant starch Type 2 diabetes glucolipid metabolism Gut microbiota Inflammation

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Study on the Correlation Between SFRP-5 Expression Level, Insulin Resistance, and Glycolipid metabolism in Gestational Diabetes Mellitus

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Journal of Clinical and Nursing Research 2023年第2期7卷 53-58页

作者： Bei Wang Chenyuan Cao Rui Li Yan An Fang Wang Yuxiang Huang Jinjin Qin Affiliated Hospital of Hebei University Baoding 071000China

Objective:To investigate the correlation between serum secretory frizzled-related protein 5(SFRP-5)expression levels and insulin resistance and glucolipid metabolism in patients with gestational diabetes mellitus(GDM).Methods:Baseline data were collected from 58 patients with GDM and 51 healthy controls who were admitted Affiliated Hospital of Hebei University from May 2020 to June ***5 concentrations in peripheral blood of pregnant women were measured,and SFRP-5 levels in patients with different GDM types and normal controls were analyzed by logistic regression ***:The levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),fasting insulin(FINS),hemoglobin A1c(HbA1c),and homeostasis model assessment-estimated insulin resistance(HOMA-IR)were higher in the observation group than in the control group,with statistically significant differences(Pmetabolism and inflammatory response.

关键词： Gestational diabetes mellitus Secretory frizzled-related protein 5 Insulin resistance glucolipid metabolism

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