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Research Progress on Prevention and Treatment of glucolipid metabolic disease with Integrated Traditional Chinese and Western Medicine

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Chinese Journal of Integrative Medicine 2017年第6期23卷 403-409页

作者： GUO Jiao Guangdong metabolic disease Research Center of Integrated Chinese and Western Medicine Guangdong Key Laboratory of metabolic disease Prevention and Treatment of Traditional Chinese Medicine Key Unit of Modulating Liver in Treating Hyperlipidemia SACM Institute of Traditional Chinese Medicine Research InstituteGuangdong Pharmaceutical UniversityGuangzhou 510006China

Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settings. However, increasing of the disease incidence, lacking of comprehensive prevention and control measurements against the key pathology point concomitant occurrence with the pattem of the single disease, single target therapy, that is leading therapeutic strategy for these metabolic disorders in the setting of Western medicine （WM）. On the basis of the combination of the advantages of integrated Chinese medicine （CM） and WM, with unified understanding of such diseases, the new concept of glucolipid metabolic disease （GLMD） is introduced. In this new concept, disorders in glucose and lipid metabolism are recognized as the key trigger and major driving force for the progress of GLMD. The key points of pathology included dysfunction of neuronal-endocrine-immune system,insulin resistance, oxidative stress, inflammation and intestinal flora imbalance. In the core pathogenic perspective of CM, it can be explained as ＂Gan （Liver） Shi Shu Xie＂（dysfunction of Gan in metabolism and emotion regulation） that will lead to the occurence/production of endogenous dampness and phlegm, blood stasis and turbid. This leads to the new concept of ＂Liver-based regulatory system for metabolic homeostasis＂ to be introduced further. The comprehensive prevention and control strategy ＂Tiao Gan Qi Shu Hua Zhuo＂（modulating Gan, trigging key metabolic system to resolve pathogenic factors such as phlegm retention and dampness）. Its representative formula Fufang Zhenzhu Tiaozhi Capsule （复方贞术调脂胶囊） is innovated under such rationales. Comment for some commonly-used CM GLMD therapeutic drugs was presented. High-level evidence-based and epidemiological and mechanism studies should be carded out to further interpret and explain of the scientific connotation of GLMD.

关键词： glucolipid metabolic disease liver-based regulatory system for metabolic homeostasis Tiao Gan （Liver） Qi Shu Hua Zhuo （modulating Gan trigging key metabolic system to resolve pathogenic factors such as phlegm retention and dampness） Chinese medicine

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Liver-Adipose Tissue Crosstalk:A Key Player in the Pathogenesis of glucolipid metabolic disease

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Chinese Journal of Integrative Medicine 2017年第6期23卷 410-414页

作者： YE De-wei RONG Xiang-lu XU Ai-min GUO Jiao Guangdong Research Center of metabolic diseases of Integrated Western and Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou(510006)China Joint Laboratory between Guangdong and Hong Kong on metabolic disease Guangdong Pharmaceutical UniversityGuangzhou(510006)China State Key Laboratory of Pharmaceutical Biotechnology the University of Hong KongHong Kong SARChina

glucolipid metabolic disease （GLMD）, a complex of interrelated disorders in glucose and lipid metabolism, has become one of the leading chronic diseases causing public and clinical problem worldwide. As the metabolism of lipid and glucose is a highly coordinated process under both physiological and diseased conditions, the impairment in the signals corresponding to the metabolism of either lipid or glucose represents the common mechanism underlying the pathogenesis of GLMD. The liver and adipose tissue are the major metabolic organs responsible for energy utilization and storage, respectively. This review article aims to summarize the current advances in the investigation of the functional roles and the underling mechanisms of the interplay between the liver and adipose tissue in the modulation of GLMD development. Fibroblast growth factor 21 （FGF21） and adiponectin represent the two major hormones secreted from the liver and adipose tissues, respectively. FGF21 exerts pleiotropic effects on regulating glucose and lipid homeostasis majorly through inducing the expression and secretion of adiponectin. Therefore, FGF21-adiponectin axis functions as the key mediator for the crosstalk between the liver and adipose tissue to exert the beneficial effects on the maintenance of the homeostasis of energy consumption. The liver- and adipose tissue-derived factors with pleiotropic effects on regulating of lipid and glucose metabolism function as the key mediator for the crosstalk between these two highly active metabolic organs, thereby coordinating the initiation and development of GLMD.

关键词： obesity type 2 diabetes mellitus insulin resistance glucolipid metabolic disease Chinese medicine

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