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Combined transplantation of GDAs^(BMP) and hr-decorin in spinal cord contusion repair

Neural Regeneration Research 2013年第24期8卷 2236-2248页

作者： Liang Wu Jianjun Li Liang Chen Hong Zhang Li Yuan Stephen JA Davies School of Rehabilitation Medicine Capital Medical University Department of Neural Functional Reconstruction of Spine and Spinal Cord China Rehabilitation Research Center Rehabilitation Center Beijing Xiaotangshan Rehabilitation Hospital Department of Neurosurgery University of Colorado Denver

Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astro- cytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, dou- ble-immunofluorescent histochemistry revealed that combined transplantation inhibited the early in- flammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was se- creted by transplanted cells, protected injured axons. The combined transplantation promoted ax- onal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte prolif- eration and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.

关键词： neural regeneration spinal cord injury astrocytes glial scar neural stem cells combined trans-plantation glial progenitor cells glial cells human recombinant decorin brain-derived growth factor glial fibrillary acidic protein grants-supported paper neuroregeneration

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