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Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury,both in vivo and in vitro

引用

Neural Regeneration Research 2018年第7期13卷 1204-1211页

作者： Pei-Dong Zheng Rajneesh Mungur Heng-Jun Zhou Muhammad Hassan Sheng-Nan Jiang Jie-Sheng Zheng Department of Neurosurgery the First Affiliated HospitalCollege of MedicineZhejiang University

Neural stem cells have great potential for the development of novel therapies for nervous system ***,the proliferation of endogenous neural stem cells following brain ischemia is insufficient for central nervous system *** B has a robust neuroprotective *** this study,we investigated the cell and molecular mechanisms underlying the neuroprotective effect of ginkgolide B on focal cerebral ischemia/reperfusion injury in vitro and in *** stem cells were treated with 20,40 and 60 mg/L ginkgolide B in *** staining was used to assess cellular expression of neuron-specific enolase,glial fibrillary acid protein and suppressor of cytokine signaling *** treatment with 40 and 60 mg/L ginkgolide B,cells were large,with long ***,the proportions of neuron-specific enolase-,glial fibrillary acid protein-and suppressor of cytokine signaling 2-positive cells increased.A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery *** hours after ischemia,ginkgolide B（20 mg/kg） was intraperitoneally injected,once a *** Longa＇s method was used to assess neurological *** was performed to evaluate the proportion of nestin-,neuron-specific enolase-and glial fibrillary acid protein-positive ***-time quantitative polymerase chain reaction was used to measure m RNA expression of brain-derived neurotrophic factor and epidermal growth *** blot assay was used to analyze the expression levels of brain-derived neurotrophic factor and suppressor of cytokine signaling *** B decreased the neurological deficit score,increased the proportion of nestin-,neuron-specific enolase-and glial fibrillary acid protein-positive cells,increased the m RNA expression of brain-derived neurotrophic factor and epidermal growth factor,and increased the expression levels of brain-derived neurotrophic factor and suppressor of cytokine sig

关键词： nerve regeneration brain-derived neurotrophic factor epidermal growth factor suppressor of cytokine signaling 2 neuron-specific enolase glial fibrillary acid protein nestin bromodeoxyuridine neurological function middle cerebral artery occlusion astrocytes neural regeneration

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