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C-MEMS-derived glassy carbon electrochemical biosensors for rapid detection of SARS-CoV-2 spike protein

Microsystems & Nanoengineering 2023年第6期9卷 247-260页

作者： Naresh Mandal Raja Mitra Bidhan Pramanick School of Electrical Sciences Indian Institute of Technology Goa403401 PondaGoaIndia School of Chemical and Materials Sciences Indian Institute of Technology Goa403401 PondaGoaIndia Centre of Excellence in Particulates Colloids and Interfaces Indian Institute of Technology Goa403401 PondaGoaIndia school of Interdisciplinary Life Sciences Indian Institute of Technology Goa403401 PondaGoaIndia

According to a World Health Organization(WHO)report,the world has experienced more than 766 million cases of positive SARS-CoV-2 infection and more than 6.9 million deaths due to COVID through May 2023.The WHO declared a pandemic due to the rapid spread of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus,and the fight against this pandemic is not over yet.Important reasons for virus spread include the lack of detection kits,appropriate detection techniques,delay in detection,asymptomatic cases and failure in mass screening.In the last 3 years,several researchers and medical companies have introduced successful test kits to detect the infection of symptomatic patients in real time,which was necessary to monitor the spread.However,it is also important to have information on asymptomatic cases,which can be obtained by antibody testing for the SARS-CoV-2 virus.In this work,we developed a simple,advantageous immobilization procedure for rapidly detecting the SARS-CoV-2 spike protein.Carbon-MEMS-derived glassy carbon(GC)is used as the sensor electrode,and the detection is based on covalently linking the SARS-CoV-2 antibody to the GC surface.Glutaraldehyde was used as a cross-linker between the antibody and glassy carbon electrode(GCE).The binding was investigated using Fourier transform infrared spectroscopy(FTIR)characterization and cyclic voltammetric(CV)analysis.Electrochemical impedance spectroscopy(EIS)was utilized to measure the change in total impedance before and after incubation of the SARS-CoV-2 antibody with various concentrations of SARS-CoV-2 spike protein.The developed sensor can sense 1 fg/ml to 1µg/ml SARS-CoV-2 spike protein.This detection is label-free,and the chances of false positives are minimal.The calculated LOD was~31 copies of viral RNA/mL.The coefficient of variation(CV)number is calculated from EIS data at 100 Hz,which is found to be 0.398%.The developed sensor may be used for mass screening because it is cost-effective.

关键词： glassy impedance linking

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Electrooxidation of sulfanilamide and its voltammetric determination in pharmaceutical formulation,human urine and serum on glassy carbon electrode

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Journal of Pharmaceutical Analysis 2018年第1期8卷 55-59页

作者： Bruno R.L.Ferraz Tiago Guimaraes Demetrius Profeti Luciene P.R.Profeti Departamento de Biologia Universidade Federal do Espírito SantoAlegre 29.500-000ESBrazil Departamento de Química e Física Universidade Federal do Espírito SantoAlegre 29.500-000ESBrazil

For the first time, sulfanilamide(SFD) was determined in otologic solution, human urine and serum by electroanalytical techniques on glassy carbon electrode(GCE). The cyclic voltammetry(CV) experiments showed an irreversible oxidation peak at t 1.06 V in 0.1 mol/L BRBS(p H ? 2.0) at 50 m V/s. Different voltammetric scan rates(from 10 to 250 m V/s) suggested that the oxidation of SFD on the GCE was a diffusioncontrolled process. Square-wave voltammetry(SWV) method under optimized conditions showed a linear response to SFD from 5.0 to 74.7 μmol/L(R ? 0.999) with detection and quantification limits of 0.92 and3.10 μmol/L, respectively. The developed SWV method showed better results for detection limit and linear range than the chronoamperometry method. It has been successfully applied to determine SFD concentration in pharmaceutical formulation, human urine and serum samples with recovery close to 100%.

关键词： Square-wave voltammetry Sulfanilamide glassy carbon electrode Biological fluids

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Voltammetric sensor based on cobalt-poly(methionine)-modified glassy carbon electrode for determination of estriol hormone in pharmaceuticals and urine

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Journal of Pharmaceutical Analysis 2019年第5期9卷 347-357页

作者： Eliziana S. Gomes Fernando R.F. Leite Bruno R.L. Ferraz Henrique A.J.L. Mourao Andrea R. Malagutti Department of Pharmacy Faculty of Biological and Health Sciences Federal University of Jequitinhonha and Mucuri Valleys MGT 367 Highway e Km 583 CEP 39100-000 Diamantina MG Brazil Department of Biology Federal University of Espírito Santo CEP 29500-000 Alegre ES Brazil Institute of Science and Technology Federal University of Jequitinhonha and Mucuri Valleys MGT 367 Highway e Km 583 CEP 39100-000 Diamantina MG Brazil

A voltammetric sensor based on the electropolymerization of cobalt-poly(methionine)(Co-poly(Met)) on a glassy carbon electrode (GCE) was developed and applied for the determination of estriol by differential pulse voltammetry (DPV) for the first time. The electrochemical properties of the Co-poly(Met)/GCE were analysed by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) were used to characterize the polymers on the GCE surface. The deposition of the Co-poly(Met) film on the GCE surface enhanced the sensor electronic transfer. CV studies revealed that estriol exhibits an irreversible oxidation peak at t0.58 V for the Co-poly(Met)/GCE (vs. Ag/AgCl reference electrode) in 0.10 mol/L Britton-Robinson buffer solution (pH=7.0). Different voltammetric scan rates (10-200 mV/s) suggested that the estriol oxidation on the Co-poly(Met)/GCE surface is controlled by adsorption and diffusion processes. Based on the optimized DPV conditions, the linear responses for estriol quantification were from 0.596 μmol/L to 4.76 μmol/L (R2 =0.996) and from 5.66 μmol/L to 9.90 μmol/L (R2 =0.994) with a limit of detection (LOD) of 0.0340 μmol/L and a limit of quantification (LOQ) of 0.113 μmol/L. The DPV-Co-poly(Met)/GCE method provided good intra-day and inter-day repeatability with RSD values lower than 5%. Also, no interference of real sample matrices was observed on the estriol voltammetric response, making the DPV-Copoly( Met)/GCE highly selective for estriol. The accuracy test showed that the estriol recovery was in the ranges 96.7%-103% and 98.7%-102% for pharmaceutical tablets and human urine, respectively. The estriol quantification in pharmaceutical tablets performed by the Co-poly(Met)/GCE-assisted DPV method was comparable to the official analytical protocols.

关键词： Estriol Electroanalysis Differential pulse voltammetry Cobalt-poly(methionine) film-modified glassy carbon electrode

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Exploration of organic superionic glassy conductors by process and materials informatics with lossless graph database

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npj Computational Materials 2022年第1期8卷 1622-1629页

作者： Kan Hatakeyama-Sato Momoka Umeki Hiroki Adachi Naoaki Kuwata Gen Hasegawa Kenichi Oyaizu Department of Applied Chemistry Waseda University3-4-1 OkuboShinjukuTokyo169-8555Japan National Institute for Materials Science(NIMS) 1-1 NamikiTsukuba305-0044Japan

Data-driven material exploration is a ground-breaking research style;however,daily experimental results are difficult to record,analyze,and share.We report a data platform that losslessly describes the relationships of structures,properties,and processes as graphs in electronic laboratory notebooks.As a model project,organic superionic glassy conductors were explored by recording over 500 different experiments.Automated data analysis revealed the essential factors for a remarkable room temperature ionic conductivity of 10^(−4)–10^(−3) S cm^(−1) and a Li^(+) transference number of around 0.8.In contrast to previous materials research,everyone can access all the experimental results,including graphs,raw measurement data,and data processing systems,at a public repository.Direct data sharing will improve scientific communication and accelerate integration of material knowledge.

关键词： ionic glassy breaking

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glassy metallic plastics

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Science China(Physics,Mechanics & Astronomy) 2010年第3期53卷 409-414页

作者： LI JianFu, WANG JunQiang, LIU XiaoFeng, ZHAO Kun, ZHANG Bo, BAI HaiYang, PAN MingXiang & WANG WeiHua Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Institute of Physics Chinese Academy of Sciences Beijing China

This paper reports a class of bulk metallic glass including Ce-, LaCe-, CaLi-, Yb-, and Sr-based metallic glasses, which are regarded as glassy metallic plastics because they combine some unique properties of both plastics and metallic alloys. These glassy metallic plastics have very low glass transition temperature (Tg^25oC to 150oC) and low Young’s modulus (~20 GPa to 35 GPa). Similar to glassy plastics, these metallic plastics show excellent plastic-like deformability on macro-, micro- and even nano-scale in their supercooled liquid range and can be processed, such as elongated, compressed, bent, and imprinted at low temperatures, in hot water for instance. Under ambient conditions, they display such metallic properties as high thermal and electric conductivities and excellent mechanical properties and other unique properties. The metallic plastics have potential applications and are also a model system for studying issues in glass physics.

关键词： glassy metallic plastic synthesizing low Tg thermoplastic properties

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A Functionalized Multi-walled Carbon Nanotube and Gold Nanoparticle Composite-modified glassy Carbon Electrode for the Detection of Enterovirus 71

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Biomedical and Environmental Sciences 2019年第7期32卷 541-545页

作者： CHENG Jing KOU Jing FAN Zhao Yu HAN Yi Qun MEI Yong GUO Zhen Zhong ZHAN Jian Bo School of Public Health Medical College Wuhan University of Science and Technology Wuhan 430065 Hubei China Hubei Province Key Laboratory of Occupational Hazard Identification and Control Wuhan University of Science and Technology Wuhan 430065 Hubei China Institute of health inspection and testing Hubei Provincial Center for Disease Control and Prevention Wuhan 430079 Hubei China

Hand, foot, and mouth disease (HFMD) is a common infectious disease in children, occurring primarily in preschool children[1_3] with infants under three years old being gen erally susceptible. The disease is caused by various enteroviruses, among which EV71 and Coxsackievirus A group 16 (Cox A16) are the most comm on ⑷.According to in formation released by the Chinese Center for Disease Control and Prevention on June 8, 2016, EV71 infection- related HFMD has been prevalent among infants and young children in China since 2007, with a high incidenee and many deaths.

关键词： glassy Carbon Electrode Detection of Enterovirus

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Electrocatalytic oxidation of hydrazine with alizarin red S as a homogenous mediator on the glassy carbon electrode

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Science China Chemistry 2010年第5期53卷 1194-1200页

作者： Mohammad Mazloum-Ardakani Roya Mazidi Mohammad Hossein Mashhadizadeh Parvanah Rahimi Mohammad Ali Karimi Department of Chemistry Faculty of ScienceYazd University Department of Chemistry Payam Noor UniversityArdakan Center Department of Chemistry Faculty of ScienceTarbiat Moalem University Department of Chemistry Faculty of SciencePayam Noor UniversitySirjan Center

Electro-catalytic oxidation and detection of hydrazine on a glassy carbon electrode,at pH 6.0,was studied by using alizarin red S as a homogeneous mediator.The overall number of electrons involved in the catalytic oxidation of hydrazine and that involved in the rate-determining step were four and one,respectively.The interfering effect of some cations,anions and organic compounds were examined.Peak current for this process varied linearly with the square root of the scan rate.The kinetic parameters,such as the electron transfer coefficient(α) and catalytic rate constant(k) ,were determined using cyclic voltammetry,linear sweep voltammetry and chronoamperometry.The electro-catalytic response was optimized with regards to the pH,scan rate,hydrazine concentration and other variables.

关键词： alizarin red S hydrazine glassy carbon electrode electro-catalytic oxidation voltammetry

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glassy Matrix of Pseudotachylite in the Yagan Extensional Detachment Fault in the Sino-Mongolian Boundary and Its Kinematic Implications

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Chinese Science Bulletin 1994年第22期39卷 1895-1899页

作者：王玉芳郑亚东臧启家张青 Department of Geology Peking University Beijing 100871 PRC

Pseudotachylite was found in the Yagan detachment fault in the Sino-Mongolian boundary area but so many generations that occurred have seldom been reported in literature.Although Wagliughlin and Spray (1992) have full... 详细信息

关键词： pseudotachylite glassy matrix TEM energy spectrum analysis.

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glassy PHASE CHANGE OF NITRIDE MATERIALS WITH RARE EARTH ADDITIVES BY HREM AND AEM

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Chinese Science Bulletin 1989年第18期34卷 1519-1521页

作者：马利泰徐友仁严东生 Shanghai Institute of Ceramics Academia Sinica

Development of high temperature Si3N4 ceramics has been attractive for heat engine components and other high temperature engineering applications Additives must be added to get a fully dense material. And because of this, glassy phase is formed at the grain boundaries which has a strong influence on the high temperature strength, fracture mechanisms,

关键词： Si3N4 glassy phase LaYO3

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Characteristics of distortion of bond length in glassy carbon nanocrystalline by Raman spectroscopy

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Chinese Science Bulletin 1996年第11期41卷 963-966页

作者：李向山华中王文宇高忠民张桂琴 Department of Material Science Jilin University Changehun 130023. China

Bond length (or lattice) distortion, crystallite size and crystal boundary structure areall important aspects in the research of nanocrystalline structure. A number of interestingworks have been published concerning the effect of lattice distortion on the properties ofnanocrystalline, but the studies of the characteristics of bond length or lattice distortionof nanocrystalline have not been specially reported. In this note, a new method analyzingbond length distortion in nanocrystalline by Raman spectroscopy is given on the basis

关键词： glassy carbon nanocrystalline transitional layers of distorted bond length expansion rate of bond length Raman spectroscopy.

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