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Journal of Nutritional Oncology 2023年第2期8卷 107-114页

作者： Yi-Chao Ma Wen-Qi Li ChenWei Fei Wang Yi-Qun Liao Bin Zhao Yu-Ji Chen Qi Zhao Jie Qiu Dong Tang Clinical Medical College Yangzhou UniversityYangzhouJiangsuChina Department of Newborn Infants Children's Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Clinical Medical College Dalian Medical UniversityDalian 116044LiaoningChina Department of General Surgery Institute of General SurgeryClinical Medical CollegeYangzhou UniversityNorthern Jiangsu People's HospitalYangzhouJiangsuChina

Background:Observational studies have shown that inflammatory bowel disease(IBD),such as ulcerative colitis(UC)and Crohn disease(CD),is associated with gingivitis and periodontal disease(GP).This study aims to investigate whether there is a causal relationship between IBD and ***:This study assessed the causal relationship between IBD and GP through a two-sample Mendelian randomization(MR)*** required data were obtained through the IEU OpenGWAS *** variable screening and the MR and sensitivity analyses were performed using the“TwoSampleMR”R ***:IBD,UC,and CD may have a causal effect on GP(IBD,inverse variance weighting[IVW]OR=1.05,95%CI=1.00–1.10,P=0.03;UC,IVWOR=1.05,95%CI=1.00–1.11,P=0.03;CD,weighted median OR=1.06,95%CI=1.00–1.13,P=0.04;simple mode OR=1.15,95%CI=1.02–1.31,P=0.03).Scatterplots,forest plots,and funnel plots showed a significant relationship between IBD and GP and confirmed the robustness of the *** sensitivity testing,no horizontal pleiotropy or heterogeneity was found in this ***:This study found a possible causal relationship between IBD(UC and CD)and GP,which deserves to be considered in clinical practice.

关键词： gingivitis Inflammatory bowel disease Mendelian randomization study Periodontal disease

Efficacy of Rabdosia Rubescens in the Treatment of gingivitis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第5期29卷 659-663页

作者：陈穗刘家荣张汉东 Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

This study evaluated the efficacy ofrabdosia rubescens against gingivitis and compared the therapeutic efficacy of different dosage forms of rabdosia rubescens. A multi-center, randomized, double-blind, double-simulation, positive-controlled and parallel trial was conducted. A total of 136 patients exhibiting clinical symptoms of gingivitis were enrolled. The subjects were randomly assigned to two groups： test group （n=67）, in which rabdosia rubescens drop pill （960 mg） and 4 tablets of simulation agent of rabdosia rubescen were orally given to the subjects three times a day for 5 days; and control group （n=69）, in which the subjects were administered the tablets of rabdosia rubescens （1000 mg） and 24 drop pills of simulation agent of rabdosia rubescens thrice daily for 5 days. The experimental protocols and diagnostic criteria were established by expert panel prior to the experiment. The clinical symptoms were graded according to the severity of the disease and quantified. The total scores and scores for each clinical symptom of gingivitis were assessed at baseline and on the 6th day post-treatment. The therapeutic efficacy was compared between the two groups and in each group itself before and after the treatment. The results showed that in the two groups, the subjects who were given rabdosia rubescens, drop pill or tablet, had a decrease in total scores and scores for each clinical symptom when compared with those before treatment （P〈0.01）. There was significant difference in the therapeutic efficacy between the test group and the control group with the efficacy rate being 92.54% and 79.71% respectively （P〈0.05）. It was concluded that rabdosia rubescens showed great promise in treating gingivitis. And rabdosia rubescens drop pill was more efficacious than rabdosia rubescens tablet.

关键词： rabdosia rubescens drop pill tablet gingivitis

Evaluation of Topical Application of Vajradanti Gel in Prevention of gingivitis

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Open Journal of Stomatology 2017年第2期7卷 105-112页

作者： Anjani Kumar Pathak Vibha Singh Mahesh Pal Tripti Mishra Kopal Goel Vaibhav Sheel Gupta Department of Periodontology Faculty of Dental Sciences King George’s Medical University Lucknow India Department of Oral and Maxillofacial Surgery Faculty of Dental Sciences King George’s Medical University Lucknow India Phytochemistry Division CSIR-National Botanical Research Institute Lucknow India Department of Prosthodontics Faculty of Dental Sciences King George’s Medical University Lucknow India

Vajradanti means strong teeth in Hindi. The medicinal properties of Vajradanti plant are well reported in Ayurveda. Its botanical name is Barleria prionitis L. and it belongs to family Acanthaecae. The use of herbal products in the field of medicine has gained popularity in recent years. In India, herbal plants are used as a regular source of medicine. Plants, such as Turmeric, Ashoka and Triphala, are some common household names being widely used nowadays. One such name is Barleria prionitis L. or Vajradanti, having anti-arthritic, anti-inflammatory and anti-fertility properties. The leaves of this flower are also believed to provide relief in tooth ache. So these properties lead us to the use of this shrub in the remedy of dental diseases. Materials and Methods: The study was conducted in the Department of Periodontology, in collaboration with the Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, India and N.B.R.I. Lucknow. A total of 80 subjects, from age group 20 - 50 years, were selected. The study unit consisted of patients of chronic gingivitis. Simple random sampling, utilizing computer generated random numbers, was employed to assign the participants to two groups, “I” and “II”, each having 40 participants. In patients of Group-I scaling and root planing was performed, whereas in patients of Group-II, scaling and root planing was performed and subjects were advised to apply Vajradanti gel twice daily after brushing. Statistical Analysis: Data were summarized as mean ± SD. Pre and post outcome results of two groups were compared by the paired t-test. Conclusions: Based on the observations and results of our study, it can be concluded that scaling and root planing remains the gold standard for the treatment of gingival and periodontal diseases while the Vajradanti gel (Barleria prionitis L.) can be effectively used as an adjunct to mechanical plaque control in prevention of chronic gingivitis.

关键词： Vajradanti Chronic gingivitis Barleria prionitis L. Bio Film Plaque

Effect of <i>Morinda citrifolia</i>L. fruit juice on gingivitis/periodontitis

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Modern Research in Inflammation 2013年第2期2卷 21-27页

作者： Jonas Glang Wolfgang Falk Johannes Westendorf Institute of Experimental and Clinical Pharmacology and Toxicology University Clinic Hamburg

The majority of the world’s population suffers from gingivitis/periodontitis. This inflammatory process is caused by several bacterial species inside the dental plaque. In vivo and in vitro experiments were set up. The patients of the in vivo group were divided into a noni and a control group. Both groups contained patients that suffered from gingivitis/periodontitis who were introduced to practice standardized, good oral hygiene. The patients in the noni group additionally used noni juice for mouth wash two times a day. The Papillae-Bleeding-Index (PBI) was evaluated comparing the status of inflammation in both groups. Bacterial probes were isolated from the patient’s gingival pouches for species identification and to carry out in vitro experiments for possible antimicrobial effects of noni juice. The Papillae-Bleeding-Index (PBI) in the noni group has “highly significantly” improved from an average of 2.25 at the beginning of the observation period (t0) to 1.01 after four weeks of noni treatment (t1), compared to a change from 2.11 at t0 to 1.95 at t1 inthe control group. A comparison of the differences of the PBI-values (t0-t1) between the noni and the control group was highly significant using a t-test on a level of p = 0.01. Only small inhibition zones were observed in the agar diffusion test on agar plates coated with aerobic, anaerobic and Candida cultures isolated from the patients gingival pouches after treatment with original or neutralized noni juice in different concentrations. Weak bacteriostatic effects occurred in the agar dilution experiments with noni juice in higher concentrations (native and neutralized noni juice). The present investigation has shown that the combination of good oral hygiene and the administration of noni juice was a promising treatment for gingivitis and periodontitis. The additional treatment with noni juice significantly mitigated the gingival inflammation.

关键词： gingivitis Periodontitis Morinda citrifolia L. Noni Bacterial Inflammation Interleukin-1

Xeroderma Pigmentosum with Desquamative gingivitis a Rare Case Report and Detailed Review of Literature

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第4期1卷 164-170页

作者： Shamimul Hasan Mohammad Abbas Khan 不详

In xeroderma pigmentosum, a rare genodermatosis, transmitted as an autosomal recessive disorder, excessive solar damage to the skin develops at an early age. The disease is characterized by cutaneous, ocular, neurological and oral changes. Oral features in the form of early development of Squamous cell carcinoma, usually at the lower lip and tip of the tongue may be seen. The disorder is associated more commonly in populations where marriage of close blood relatives is common. Treatment of the disorder includes avoidance of Ultra violet radiation, topical application of 5 fluorouracil to treat actinic keratoses, and regular evaluation by an optholmologist, dermatologist, and neurologist. Genetic counseling is an important aspect as an increased incidence of consanguineous marriages have been reported with this disorder. Here, we report an interesting case of xeroderma pigmentosum in an 18 year old male patient who presented with characterstic desquamation of gingiva, fissured tongue and geoghraphic tongue.

关键词： Oral Genodermatosis Xeroderma Pigmentosum Desquamative gingivitis Developmental Tongue Lesions

Effects of Huanglian Jiedu Decoction on Rat gingivitis Induced by LPS

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Medicinal Plant 2018年第5期9卷 89-92,96页

作者： Fangbo ZHANG Miao XU Yi ZHANG Defeng LI Hongjie WANG Haiyu ZHAO Baolin BIAN Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences State Intellectual Property Office of the PRC

[Objectives] To evaluate the effects of Huanglian Jiedu Decoration( HLJD) on the treatment of rat gingivitis with excess internal heat through injecting lipopolysaccharide( LPS) in tooth-supporting tissues. [Methods]Gingival inflammation was established by LPS injection. Male SD rats were randomly divided into 7 groups: normal control group( no treatment group),solvent control group,model group( LPS injection),HLJD low dose group( 0. 25 g/kg),HLJD medium dose group( 0. 50 g/kg),HLJD high dose group( 1. 00 g/kg),and metronidazole and fenbufen capsule( MFC) group. Water intake and urine volume were observed through metabolic cage feeding; gingival tissue protein expressions were detected by LC-ESI-MS/MS method; oxidative stress-related molecules such as total superoxide dismutase( T-SOD) and hydrogen peroxidase catalase( CAT) were detected by the biochemical kit combined with a microplate reader; expressions of TSC related with energy metabolism-related signaling pathway were detected by western blotting. [Results]When rat gingivitis was injected by LPS,both water intake and urine volume were decreased,the levels of T-SOD and CAT were decreased,and the expressions of fructose-bisphosphate aldolase C,triosephosphate isomerase 1 and TSC2 were increased. Huanglian Jiedu Decoration can increase water intake and urine volume,increase the levels of T-SOD and CAT,reduce the expressions of fructose-bisphosphate aldolase C and triosephosphate isomerase 1,and inhibit the expression of energy metabolism-related pathway molecule TSC2. [Conclusions] Huanglian Jiedu Decoration can treat rat gingivitis through inhibiting energy metabolism and oxidative stress such as TSC signal pathway and glycolysis related molecules.

关键词： Huanglian Jiedu Decoration I Excess internal heat gingivitis Glycolysis Energy metabolism Oxidative stress

Knowledge and the Attitude on the Use of Mouthwash among Two Selected Senior High Schools in Kumasi

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Open Journal of Stomatology 2024年第5期14卷 218-234页

作者： Ama Agyeibea Amuasi Kwame A. Koranteng Joseph Abu-Sakyi The Department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

BACKGROUND: The route of most systemic diseases begins in the oral cavity. Oral health knowledge of mouthwashes and their uses is indispensable for the general population and especially adolescents. The use of mouthwash by adolescents can be a beneficial adjunct to their oral hygiene routine, providing additional protection against dental diseases and promoting fresher breath. Overuse or misuse of mouthwash, particularly those containing alcohol or other potentially irritating ingredients, may lead to adverse effects such as oral mucosal irritation, dry mouth, or alteration of the oral microbiome. OBJECTIVES: To determine the knowledge, attitude, and use of mouthwash among senior high school students in Kumasi. METHODOLOGY: 120 students responded to a standard questionnaire by a convenient sample technique. The Statistical Package for Social Sciences (SPSS) 22.0 and MS Excel were used for data management and analysis. The results of the study were presented using tables, bar charts, and pie chart. RESULTS: The ages of the respondents ranged from 14 to 20 years. Out of the 120 participants, 71 students that represent 59.2% of the total, used mouthwash. Majority of the participants (63%) utilized a mouthwash after brushing their teeth. 49% of the participants reported using mouthwash to address halitosis, 37% used it to combat periodontal disease, and 10% used it for relief from a sore throat. CONCLUSION: In general, most of the participants who use mouthwash had excellent knowledge and a positive attitude toward the use of mouthwash.

关键词： Oral Cavity Mouthwash Plaque Biofilm gingivitis Convenient Sampling

Oral Hygiene in the Presence of Orthodontic Therapy

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Journal of Biosciences and Medicines 2024年第2期12卷 98-110页

作者： Emmanuel John Aryeetey Hicham Benyahia Fatima Zaoui Faculty of Dental Medicine Mohammed University in Rabat Rabat Morocco

Orthodontic treatment offers great advantages in improving facial and smile aesthetics, self-confidence and the function of the stomatognathic apparatus. The pursuit of these advantages makes use of orthodontic appliances that could be fixed or removable. However, it’s worth stating that these appliances interfere with tooth brushing, making it more difficult to brush teeth effectively. Orthodontics appliances therefore promote the accumulation of dental plaque, which results in both quantitative and qualitative changes in the oral microbiota, hence, exposing patients to several adverse effects such as White spot lesions, dental caries, periodontal pathologies and halitosis. For this reason, oral assessment of patients before, during and after treatment is necessary as well as oral hygiene instructions and motivation. Orthodontists therefore, should educate patients on oral and periodontal hygiene in order to control dental and periodontal complications. Prescriptions of plaque control materials adapted to each patient are done in order to optimize the final result and minimize unwanted complications.

关键词： Orthodontic Treatment Oral Microbiome Oral Hygiene Periodontitis gingivitis Orthodontic Fixed Appliances Orthodontic Removable Appliances White Spot Lesions (WSL)

Correlation of Levels of Oncostatin M Cytokine in Crevicular Fluid and Serum in Periodontal Disease

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International Journal of Oral Science 2010年第4期2卷 198-207页

作者： ManojKumar Thorat Pradeep AR Garima Garg Department of Periodontics Government Dental College and Research Institute

Aim The aim of this study was to measure the level of Oncostatin M （OSM） a gp130 cytokine in the gingival crevicular fluid （GCF） and serum of chronic periodontitis patients and to find any correlation between them before and after periodontal therapy （scaling and root planing,SRP）. Methodology 60 subjects （age 25-50 years） were enrolled into three groups （n=20 per group）,group Ⅰ （healthy）,group Ⅱ （gingivitis） and group III （chronic periodontitis）. Group Ⅲ subjects were followed for 6-8 weeks after the initial periodontal therapy （SRP） as the group Ⅳ （after periodontal therapy）. Clinical parameters were assessed as gingival index （GI）,probing depth （PD）,clinical attachment level （CAL）,and radiographic evidence of bone loss. GCF and serum levels of OSM were measured by using Enzyme Linked Immunosorbent Assay （ELISA）. Results It was found that mean OSM levels had been elevated in both the GCF and serum of chronic periodontitis subjects （726.65 ± 283.56 and 65.59 ± 12.37 pg·mL-1,res-pectively） and these levels were decreased proportionally after the periodontal therapy （95.50 ± 38.85 and 39.98 ± 16.69 pg·mL-1 respectively）. However,OSM was detected in GCF of healthy subjects （66.15 ± 28.10 pg·mL-1） and gingivitis-suffering subjects （128.33 ± 22.96 pg·mL-1） and was found as below the detectable limit （≈0.0 pg·mL-1） in the serum of same subjects. Significant correlation has been found between clinical parameters and GCF-serum levels of OSM. Conclusion Increased OSM level both in the GCF and serum,and the decreased levels after initial periodontal therapy （SRP） may suggest a use as an inflammatory bio-marker in the periodontal disease.

关键词： cytokine Oncostatin M chronic periodontitis gingivitis scaling and root planning

Correlation of periodontal diseases with intracranial aneurysm formation:novel predictive indicators

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Chinese Neurosurgical Journal 2021年第3期7卷 165-170页

作者： Keyun Liu Jia Sun Lingling Shao Hongwei He Qinglin Liu Youxiang Li Huijian Ge Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityNo.119West Road of South Fourth RingFengtaiBeijing 100070People’s Republic of China Department of Stomatology Tianjin Stomatological HospitalHospital of StomatologyNankai UniversityTianjin 300041People’s Republic of China Department of Tuberculosis Beijing Tuberculosis and Thoracic Tumor InstituteBeijing Chest HospitalCapital Medical UniversityBeijing 101149People’s Republic of China

Background:We investigated whether periodontal diseases,specifically,periodontitis and gingivitis,could be risk factors of the incidence of intracranial aneurysms(IAs).Methods:We performed a case–control study to compare the differences in the periodontal disease parameters of 281 cases that were divided into the IAs group and non-IAs *** cases underwent complete radiographic examination for IAs and examination for periodontal ***:Comparing with those in the non-IAs group,the cases in the IAs group were older(53.95±8.56 vs 47.79±12.33,p50 years)and hypertension were predictive risk factors of aneurysm formation(odds ratio[OR]1.047,95%confidence interval[95%CI]1.022–1.073,p1.1 and plaque index>1.5)had the correlation with IAs formation(p=0.007 and pgingivitis or periodontitis,combining with hypertension,is significantly associated with the incidence of IAs.

关键词： gingivitis Intracranial aneurysms Inflammation Periodontitis