检索结果-南通市图书馆

Integrative analysis of mirNA and mRNA profiles reveals that gga-mir-106-5p inhibits adipogenesis by targeting the KLF15 gene in chickens

引用

Journal of Animal Science and Biotechnology 2022年第6期13卷 1671-1689页

作者： Weihua Tian Xin Hao Ruixue Nie Yao Ling Bo Zhang Hao Zhang Changxin Wu National Engineering Laboratory for Animal Breeding Beijing Key Laboratory for Animal Genetic ImprovementCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Sanya Institute of China Agricultural University Hainan 572025 SanyaChina.

Background:Excessive abdominal fat deposition in commercial broilers presents an obstacle to profitable meat quality,feed utilization,and *** fat deposition depends on the proliferation of preadipocytes and their maturation into adipocytes,which involves a cascade of regulatory *** evidence has shown that microRNAs(mirNAs)serve as post-transcriptional regulators of adipogenic differentiation in ***,the mirNA-mediated molecular mechanisms underlying abdominal fat deposition in chickens are still poorly *** study aimed to investigate the biological functions and regulatory mechanism of mirNAs in chicken abdominal ***:We established a chicken model of abdominal adipocyte differentiation and analyzed mirNA and mRNA expression in abdominal adipocytes at different stages of differentiation(0,12,48,72,and 120 h).A total of 217 differentially expressed mirNAs(DE-mirNAs)and 3520 differentially expressed genes were *** prediction of DE-mirNAs and functional enrichment analysis revealed that the differentially expressed targets were significantly enriched in lipid metabolism-related signaling pathways,including the ppAR signaling and MApK signaling pathways.A candidate mirNA,gga-mir-106-5p,exhibited decreased expression during the proliferation and differentiation of abdominal preadipocytes and was downregulated in the abdominal adipose tissues of fat chickens compared to that of lean ***-mir-106-5p was found to inhibit the proliferation and adipogenic differentiation of chicken abdominal preadipocytes.A dual-luciferase reporter assay suggested that the KLF15 gene,which encodes a transcriptional factor,is a direct target of ***-mir-106-5p suppressed the posttranscriptional activity of KLF15,which is an activator of abdominal preadipocyte proliferation and differentiation,as determined with gain-and loss-of-function ***:gga-mir-106-5p function

关键词： Abdominal fat Adipogenesis Chickens gga-mir-106-5p KLF15 mirNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：