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Management of Trauma to the External genitalia at the Nianankoro-Fomba Hospital in Segou Mali

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Open Journal of Urology 2022年第6期12卷 376-382页

作者： Sory Ibrahim Koné Abdoulaye Kassogué Brehima Samaké Mahamoudou Keita Tidiani Traore Abdoulaye Nouhoum Coulibaly Mamadou Adama Togo Thierno Boubacar Bagayoko Adama Bah Aminata Fofana Alpha Sanogo Damissa Coulibaly Sidi Modibo Doucouré Honoré Jean Gabriell Berthé Urology Department The Nianankoro Fomba Hospital Ségou Mali Paediatric Ward The Nianankoro Fomba Hospital Ségou Mali General Surgery Department The Nianankoro Fomba Hospital Ségou Mali Obstetrics and Gynaecology Department The Nianankoro Fomba Hospital Ségou Mali Ophthalmology Department The Nianankoro Fomba Hospital Ségou Mali Forensic Medicine Department The Nianankoro Fomba Hospital Ségou Mali ENT Department The Nianankoro Fomba Hospital Ségou Mali Cardiology Department The Nianankoro Fomba Hospital Ségou Mali Department of General Medicine The Nianankoro Fomba Hospital Ségou Mali Social Security Fund Ségou Mali Department of Urology CHU du Point G Bamako Mali

Trauma to the male genitalia is not very common and mainly affects a young population. There is probably a particular instinct in men to defend their external genitalia;indeed, in the flaccid state, the penis is little exposed, and fairly well protected and its mobility allows it to move with the impact of trauma and thus reduce the vulnating force. Open trauma is rare, as is testicular dislocation, the most common being closed trauma. Testicular trauma is an uncommon accident that affects young people. Trauma is most often caused by road and traffic accidents. Animal bites are rare, as is genital self-mutilation related to a psychiatric disorder. Surgical exploration is the rule except in cases of moderate testicular trauma. Our objective was to report our experience in an emergency context where treatment is poorly codified and to review the literature. We recorded four patients with external genitalia trauma managed in the urology department from April 2013 to March 2022. Our patients were children with open genitalia trauma following a traffic accident, scrotal injuries were encountered in three patients, and additional penile injuries in one patient. All patients were treated surgically. The follow-up was straightforward.

关键词： Trauma genitalia Open Segou

Contribution of the Medical Imaging in Care of Ambiguous genitalia

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Open Journal of Radiology 2018年第2期8卷 125-130页

作者： Zanga Sore Moussa Diallo Ousseini Ouattara Boubakar Napon Aischa Madina Bamouni Yomboue Abel Cisse Rabiou Radiology Department of Charles de Gaulle Teaching Paediatric Hospital Ouagadougou Burkina Faso Radiology Department of Yalgado Ouédraogo Teaching Hospital Ouagadougou Burkina Faso

We report a case of ambiguous genitalia in a 15-year-old patient to demonstrate input of medical imaging in the diagnosis and care of this rare congenital deformation. Disorders of sexual differentiation (DSD) have been defined as congenital conditions in which development of chromosome, gonad, or anatomic sex is atypical and that raise an issue in the sex assignment. In lower socioeconomic countries where antenatal diagnosis is almost non-existent, due to lack of technical facilities, their medical and surgical management is hard. The case which we report was investigated by ultrasonography and genitography, which remains primary indications in our context.

关键词： Ambiguous genitalia Karyotype Ultrasonography Genitography

External genitalia Gangrene: Clinical, Therapeutic Aspects and Prognosis at University Hospital Souro Sanou of Bobo Dioulasso (Burkina Faso)

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Open Journal of Urology 2017年第12期7卷 235-242页

作者： Timothée Kambou Adama Ouattara Abdoulkarim Paré Brahima Kirakoya Fasnéwindé Aristide Kaboré Hassan Dogo Hamidou Bako Department of Urology Sanon Souro Teaching Hospital Bobo Dioulasso Burkina Faso Department of Urology Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Department of Surgery Division of Urology University of Maiduguri Teaching Hospital Maiduguri Nigeria

Objective: To describe the clinical aspects and the management of external genitalia gangrene in the Urology department of the Bobo Dioulasso CHUSS. Patients and methods: This was a retrospective and descriptive study over a period of 6 years from January 2011 to December 2016, which covered 54 patients hospitalized in the urology department of the University Hospital Souro Sanou for external genitalia gangrene. Results: The mean age of our patients was 53.8 years. The large ulcero-necrosis of scrotum was the main reason for reference. Our patients consulted on average 8.23 days after the onset of symptomatology. A risk factor was found in 44.2% of cases and a cause was identified in 65.3% of patients. A urogenital cause was present in 32.7%. Probabilistic antibiotic therapy and medical reanimation were systematic at admission. Debridement was performed on average 18 hours after admission and 10 patients had more than one debridement. We noted a mortality rate of 5.5%. Conclusion: Fournier’s gangrene is a serious infectious disease whose diagnosis is often delayed in our context. Early surgical debridement remains the essential therapeutic gesture to reduce mortality.

关键词： Gangrene External genitalia Debridement

Differential diagnosis of ambiguous genitalia in Chinese patients

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生殖医学杂志 2002年第Z1期11卷 38-41页

作者： Tian Qinjie(田秦杰) Ge Qinsheng(葛秦生) Division of Reproductive Endocrinology Department of Obstetrics & Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science 100730 Beijing Division of Reproductive Endocrinology Department of Obstetrics & Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science 100730 Beijing

Objective: To study the etiology and differential diagnos is of ambiguous ***: One hundred and five cases of ambiguous genitalia with disorders of sexual differentiation were analyzed based on clinical characterist ics and basic research. Results: Ambiguous genitalia are closely related to the functio n of androgen. It could be classified into 3 groups: androgen excess, androgen d eficiency and failure of gonadal differentiation. Differential diagnosis depends on clinical manifestations, chromosome examination, serum hormone determination s, final gonadal pathology, receptor study ***: Ambiguous genitalia are related to abnormal androgen ic effect and early correct etiological diagnosis is the key to its management.

关键词： Ambiguous genitalia Androgen Chromosome

Severe External genitalia Lesion by Firearm: A Case Report

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Open Journal of Urology 2015年第10期5卷 188-191页

作者： Mahamat Ali Mahamat Sidi Sougui Choua Ouchemi Olivier Ngaringuem Mohamed Jalloh Lamine Niang Serigne M. Gueye University of N’Djaména and National General Reference Hospital (HGRN) N’Djaména Tchad Grand Yoff General Hospital (HOGGY) of Dakar Dakar Senegal

Gunshot wounds to external genitalia are rare either in war field and civilian setting accounting for 2% - 4% of all injuries with often a lesion to the urinary tract. We report a case of external genital injury in a 27 years old man, accidentally injured by his own arm when he pressed the trigger of his gun placed in his pants. He had no past medical or surgical history, he presented to the emergency room (ER) with hemorrhagic scrotal and penile injuries with adjacent urethral tissue damage. He underwent a scrotal flap urethroplasty, and realignment of the corpus cavernosa and the tunica albugina. The patient lost his Foley catheter at post-operative day 3 and subsequently developed a urethral stenosis. Gunshot wounds to external genitalia are rare. A good reconstruction is necessary to avoid an impact on sexual and voiding function.

关键词： Trauma External genitalia Gunshot

Identification and functional characterization of doublesex gene in the testis of Spodoptera litura

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Insect Science 2019年第6期26卷 1000-1010页

作者： Qian Du Liang Wen Si-Chun Zheng Hong-Lun Bi Yong-Ping Huang Qi-Li Feng Lin Liu Guangzhou Key Laboratory of Insect Development Regulation and Applied Research Institute of Insect Science and Technology School of Life Sciences South China Normal University GuangzhouChina Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Science Chinese Academy of Sciences ShanghaiChina

Fusion of the testis occurs in most Lepidoptera insects, including Spodoptera litura, an important polyphagous pest. Testicular fusion in S. litura is advantageous for male reproduction, and the molecular mechanism of fusion remains unknown. Doublesex influences the formation of genitalia, the behavior of courtship, and sexually dimorphic traits in fruit-fly and silkworm, and is essential for sexual differentiation. However, its purpose in the testis of S. litura remains unknown. The doublesex gene of S. litura (Sldsx) has male-specific SldsxM and female-specific SldsF isoforms, and exhibits a higher expression level in the male testis. At the testicular fusion stage (L6D6), Sldsx attained the highest expression compared to the pre-fusion and post-fusion periods. Moreover, Sldsx had a higher expression in the peritoneal sheaths of testis than that of germ cells in the follicle. CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/Cas9) was applied to S. litura to determine the role of Sldsx. A mixture of single guide RNA messenger RNA and Cas9 protein (300 ng/μL each) was injected into eggs within 2 h following oviposition. CRISPR/Cas9 successfully induced genomic mutagenesis of Sldsx at Go generation. The mutant males had smaller testis surrounded by less tracheae. Moreover, the mutant males had abnormal external genitalia and could not finish mating with wild-type females. Additionally, testes were fused for almost all mutant males. The results showed that Sldsx was not related to testicular fusion, and is required for both testis development and the formation and function of external genitalia in S. litura. The main roles of doublesex on the male are similar to other insects.

关键词： CRISPR/Cas9 system doublesex external genitalia Spodoptera litura testis

Gene expression during genital morphogenesis in the ground beetle Carabus maiyasanus

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Insect Science 2020年第5期27卷 975-986页

作者： Shota Nomura Tomochika Fujisawa Teiji Sota Department of Zoology Graduate School of ScienceKyoto UniversitySakyoKyotoJapan

To investigate the developmental genetics of genital formation in the carabid beetle Carabus maiyasanus,we compared gene expression patterns among five stages using transcriptomic RNA sequencing data from abdominal segments and genitalia in the third(last)larval instar(including prepupa)and pupal *** identified 18839 genes,of which 10796 were differentially expressed among stages or between *** were relatively few differentially expressed genes(DEGs)between the sexes(3%).The DEGs were clustered into six groups,mainly according to stage-specific expression *** in clusters 1-3 showed high expression levels before pupation and low expression levels during the pupal period,whereas genes in clusters 46 showed high expression levels from the prepupal to the pupal *** related to the initial pupation process and differentiation of genital discs in Drosophila were involved in clusters 4 and 6 and showed low expression levels at early third instar and elevated expression levels from the early prepupal stage,suggesting that the pupation process and genital differentiation started in the prepupal *** 4 and 5 included developmental genes related to organ size control,which may be important in the formation of internal genital structures during the pupal stage.

关键词： Carabus genitalia Ohomopterus pupation RNA-seq transcriptome

Morphological traits for sex identification of the oriental armyworm,Mythimna separata(Lepidoptera:Noctuidae)

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Journal of Integrative Agriculture 2020年第6期19卷 1458-1463页

作者： CHEN Lin PAN Qin-jian Muhammad Saad WAQAS LIU Tong-xian State Key Laboratory of Crop Stress Biology for Arid Areas/Key Laboratory of Integrated Pest Management on the Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYangling 712100P.R.China State Key Laboratory of Rice Biology/MOA Key Lab of Molecular Biology of Crop Pathogens and Insects/Institute of Insect Sciences Zhejiang UniversityHangzhou 310058P.R.China

The oriental armyworm,Mythimna separata(Lepidoptera:Noctuidae)is a harmful pest which causes heavy loss in agricultural *** identification of *** is very important for understanding the biology and management of this *** of fast and convenient methods to identify *** female and male is the necessary prerequisite for con ducting gender-related *** this study,new methods to differentiate sex of *** at pupal and adult stages were *** results showed that posterior abdominal segments containing genital organs which are morphological traits to differentiate female and *** openings are important characters for the female and male pupae *** female pupa,it locates on the ventral side of eighth and ninth abdominal segments and appears as a visible longitudinal suture;for male pupa,it locates on the ventral side of the ninth abdominal segment and appears as a short slit surrounded by a pair of visible semicircular *** numbers are another indicator for sex differentiation of *** female has three-bristled frenulum and each male has one bristled-frenulum near the base of hind wing of each side of moth *** confirmed the two sex differentiation methods manually by dissecting genitalia of adults and found their genger was as same as what we examined the sex of pupae and adults using the morphological methods.

关键词： sex identification pupa and adult genital opening frenulum genitalia

Penis size and sperm quality,are all bats grey in the dark?

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Current Zoology 2019年第6期65卷 697-703页

作者： Nicolas Jean FASEL Marta KOIODZIEJ-SOBOCINSKA Ewa KOMAR Marcin ZEGAREK Ireneusz RUCZYNSKI Department of Evolutionary Ecology Leibniz Institute for Zoo and Wildlife ResearchAlfred-Kowalke-StrasseBerlinGermany Mammal Research Institute Polish Academy of Sciences Biatowiez.aPoland

Penises play a key role in sperm transport and in stimulating female *** should impact post-copulatory competition,and expose penis characteristics to sexual selective *** of male genitalia have repeatedly reported negative static allometries,which mean that,within species,large males have disproportionally small genitals when compared with smaller *** of some sperm-storing bat species may stand as an exception to such a pattern by arousing from hibernation to copulate with torpid *** selection for large penises might take place,if a long organ provides advantages during post-copulatory competition and/or if females have evolved mechanisms allowing the choice of sire,relying on characters other than pre-copulatory traits(e.g.,penis size).In this study,we measured dimensions of the erected penis in 4 sperm-storing bat ***,we collected sperm and evaluated the link between penis dimensions and sperm *** results revealed steep allometric slopes of the erected penis length in Barbastella barbastellus and an inverse allometry of penis head width in Myotis *** detailed studies of copulatory behavior are urgently needed to explain the range of observed scaling ***,penis head width correlates with sperm velocity in Plecotus *** this last species,we propose that penis shape might act as a marker of male fertility.

关键词： Barbastella barbastellus genitalia honest signaling Myotis nattereri Plecotus auritus sperm competition sperm quality sperm velocity Vespertilio murinus.