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Relationship between Single Nucleotide Polymorphisms in -174G/C and -634C/G Promoter Region of Interleukin-6 and Prostate Cancer

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第6期28卷 693-696页

作者：包世新杨为民周四维叶章群 Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

The association between the single nucleotide polymorphisms （SNPs） in -174G/C and -634C/G of interleukin-6 （IL-6） promoter region and prostate cancer was examined in the population of Han people in Hubei region. TaqMan PCR was employed for the gene-typing of -174G/C and -634C/G in promoter region of IL-6 gene to compare the prostate cancer patients and normal controls in terms of genotype frequency, allele frequency and risk of prostate cancer. Enzyme-linked immu- nosorbent assay （ELISA） was used for the detection of IL-6 concentration in peripheral blood of the patients with prostate cancer and the relationship between the IL-6 level and the genotype was studied. Our results showed that in all the subjects, the genotype of genetic locus -174G/C was found to be GG and no CG and CC were observed. There was a significant difference in gene frequency of GG, CG and CC of -634C/G and allele frequency of G and C between prostate cancer patients and normal controls （P〈0.05） and the gene frequency of GG＋CG increased with the clinical stages and pathological grades of prostate cancer. The IL-6 level in GG＋CG group was significantly higher than that in CC group. It was concluded that no SNP in -174G/C IL-6 promoter region was found in the population of Han people in Hubei region. The SNP in -634C/G was, to some extent, associated with the development and progression of prostate cancer. The population with GG＋CG genetype has higher risk for prostate cancer.

关键词： interleukin-6 prostate cancer single nucleotide polymorphisms allele genetype

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Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach

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Open Journal of Genetics 2019年第3期9卷 65-75页

作者： Nuntika Thavichachart Prathan Rutchatajumroon Taisei Mushiroda Anchalee Prasansuklab Sookjaroen Tangwongchai Puangsoi Worakul Buranee Kanchanatawan Siriluck Suppapitiporn Atapol Sughondhabirom Chutima Roomruangwong Ongart Charoensook Wasun Chantratita Atsushi Takahashi Michiaki Kubo Naoyuki Kamatani Yusuke Nakamura Department of Psychiatry Faculty of Medicine Chulalongkorn University Bangkok Thailand Thailand Center of Excellence for Life Sciences (Public Organization) Ministry of Science and Technology Bangkok Thailand Laboratory for Pharmacogenetics RIKEN Center for Genomic Medicine Kanagawa Japan College of Public Health Sciences Chulalongkorn University Bangkok Thailand Center for Medical Genomics Ramathibodi Hospital Mahidol University Bangkok Thailand Laboratory for Statistical Analysis RIKEN Center for Genomic Medicine Kanagawa Japan Laboratory for Genotyping Development RIKEN Center for Genomic Medicine Kanagawa Japan Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan

Background: Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster. “Tsunami” occurred in Andaman coast of Thailand on December 26, 2004, in which 33.6% of survivors were diagnosed as PTSD. This study aimed to explore the single nucleotide polymorphism (SNP). rs267943 genotype is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and psychosocial factors for PTSD. Methods: Participants (N = 1970) were recruited from volunteers who have complete data both of DAP1 gene and psychosocial factor. Results: Using a binary logistic regression model, significant gene-environment interactions were found for the single nucleotide polymorphism (SNP) rs267943 and psychosocial factors including depression (adj. OR = 6.0, 95% CI = 4.29 - 8.39), neurotic personality (adj. OR = 2.73, 95% CI = 2.18 - 3.42), planning (adj. OR = 1.52, 95% CI = 1.20 - 1.93), use of emotional support (adj. OR = 1.32, 95% CI = 1.21 - 1.94) with statistical significant p Conclusion: This study demonstrated that GxE studies can be utilized to shed light on the origins of PTSD.

关键词： Death-Associated Protein 1 Gene (DAP1) Gene-by-Environment Interaction (GxE) genetype Posttraumatic Stress Disorder (PTSD) Psychosocial Factors Tsunami

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The research of the correlation between human papillomavirus and cervical lesions

The research of the correlation between human papillomavirus...

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中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： Baojun Wei Minjie Wang Xuexiang Li Jun Qi The Clinical Laboratory of Cancer Hospital Chinese Academy of Medical Sciences

Objective To investigate the correlation between the positive rate of HPV genetypes and the severity of cervical *** Flow-through Hybridization wag employed to detect the positive rate of HPV and the genetypes of HPV in cervical *** 280 samples came from the cervical lesion patients from January to June of this year at our *** of samples were detected by pathological *** them included cervical cancer(n=100),CINⅠ(n=30),CINⅡ(n=50),CINⅢ(n=100). Following,DNA was extracted from these samples and amplified by *** amplified products were hybridized with gene chip marked with 21 kinds of HPV genetype. Finally,the results were analyzed by SPSS 12.0,x2 test. Results The positive rate of HPV test in CINⅠ,CINⅡ,CINⅢand cervical cancer 37%、52%、56%and 82%respectively (P<0.05).Conclusions The positive rate increased with the process developing of cervieal *** is significant correlation between HPV infection and cervical lesion.

关键词： Human Papillomavims Cervical Lesion genetype

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