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CYP4F2 polymorphism as a genetic risk factor for major hemorrhagic complications in Chinese patients on warfarin therapy

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Journal of Geriatric Cardiology 2012年第2期9卷 209-210页

作者： Hong-Juan Wang Cong Ma Jie Yang Qiang Xu Yan Zhang Lei Gao Bin Xu Yu-Xiao Zhang Yang Li Tong Yin Institute of Geriatric Cardiology General Hospital of Chinese People's Liberation ArmyBeijing 100853China

Warfarin is a commonly used anticoagulant with a narrow therapeutic range and risk of hemorrhagic complications. After CYP2C9 and VKORC1, CYP4F2 was confirmed as the third principle genetic determinant of warfarin dos... 详细信息

关键词： CYP4F2 genetic risk factor Warfarin Complications

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inMTSCCA:An Integrated Multi-task Sparse Canonical Correlation Analysis for Multi-omic Brain Imaging genetics

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Genomics, Proteomics & Bioinformatics 2023年第2期21卷 396-413页

作者： Lei Du Jin Zhang Ying Zhao Muheng Shang Lei Guo Junwei Han The Alzheimer's Disease Neuroimaging Initiative Department of Intelligent Science and Technology School of AutomationNorthwestern Polytechnical UniversityXi'an 710072China

Identifying genetic risk factors for Alzheimer's disease(AD)is an important research *** date,different endophenotypes,such as imaging-derived endophenotypes and proteomic expression-derived endophenotypes,have shown the great value in uncovering risk genes compared to case-control ***,a co-varying pattern of different omics-derived endophenotypes could result from the shared genetic ***,existing methods mainly focus on the effect of endophenotypes alone;the effect of cross-endophenotype(CEP)associations remains largely *** this study,we used both endophenotypes and their CEP associations of multi-omic data to identify genetic risk factors,and proposed two integrated multi-task sparse canonical correlation analysis(inMTSCCA)methods,i.e.,pairwise endophenotype correlationguided MTSCCA(pcMTSCCA)and high-order endophenotype correlation-guided MTSCCA(hocMTSCCA).pcMTSCCA employed pairwise correlations between magnetic resonance imaging(MRI)-derived,plasma-derived,and cerebrospinal fluid(CSF)-derived endophenotypes as an additional *** used high-order correlations among these multi-omic data for *** figure out genetic risk factors at individual and group levels,as well as altered endophenotypic markers,we introduced sparsity-inducing penalties for both *** compared pcMTSCCA and hocMTSCCA with three related methods on both simulation and real(consisting of neuroimaging data,proteomic analytes,and genetic data)*** results showed that our methods obtained better or comparable canonical correlation coefficients(CCCs)and better feature subsets than *** importantly,the identified genetic loci and heterogeneous endophenotypic markers showed high ***,jointly using multi-omic endophenotypes and their CEP associations is promising to reveal genetic risk factors.

关键词： Brain imaging genetics Multi-omic endophenotype Cross-endophenotype association genetic risk factor Medical imageanalysis

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genetic variants involved in gallstone formation and capsaicin metabolism,and the risk of gallbladder cancer in Chilean women

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World Journal of Gastroenterology 2010年第3期16卷 372-378页

作者： Sergio Báez Yasuo Tsuchiya Alfonso Calvo Martha Pruyas Kazutoshi Nakamura Chikako Kiyohara Mari Oyama Masaharu Yamamoto Department of Surgery Sótero del Río Hospital Department of Community Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences Department of Anatomic Pathology Sótero del Río Hospital Department of Preventive Medicine Graduate School of Medical SciencesKyushu University Faculty of Health Sciences Niigata University of Health and Welfare

AIM:To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffi n block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman SNP Genotyping Assays or Custom Taqman SNP Genotyping ***:The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR:0.14,95% CI:0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR:5.04,95% CI:1.43-17.8).CONCLUSION: genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs 708272 polymorphisms may be related to the risk of developing GBC in Chilean women.

关键词： genetic risk factor Gallbladder cancer Gallstone genetic polymorphism Apolipoprotein B Cholesteryl ester transfer protein

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Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan

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Neural Regeneration Research 2018年第8期13卷 1309-1312页

作者： Ryan J.Piers Department of Psychological and Brain Sciences Boston University

Apolipoprotein E4（ApoE4） is a prominent genetic risk factor for Alzheimer＇s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan（i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates）. Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer＇s disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.

关键词： MRI healthy aging genetic risk factor biomarker Alzheimer's disease

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