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Geochemical characteristics and genetic model of dolomite reservoirs in the eastern margin of the Pre-Caspian Basin

Petroleum Science 2012年第2期9卷 161-169页

作者： Wang Shuqin Zhao Lun Cheng Xubin Fan Zifei He Ling School of Energy Resources China University of GeosciencesBeijing 100083China Research Center of Central Asia and Russia Institute of Petroleum Exploration&DevelopmentPetroChinaBeijing100083China Institute of Geological Exploration&Development PetroChina Chuanqing Drilling Engineering Company LimitedS ichuan 610051China

The widespread Carboniferous KT-I dolomite in the eastern margin of the Pre-Caspian Basin is an important hydrocarbon reservoir. The dolomite lithology is dominated by crystalline dolomite. The δ18O values range from -6.71‰ to 2.45‰, and average 0.063‰, obviously larger than -2.5‰, indicating low-temperature dolomite of evaporation origin. Stable strontium isotope ratios （87Sr/86Sr） range from 0.70829 to 0.70875 and average 0.708365, very consistent with 87Sr/86Sr ratios in Carboniferous seawater. Chemical analysis of Ca and Mg elements shows that the dolomite has 9.1 mole% excess Ca or even higher before stabilization. The degree of order of dolomite is medium–slightly poor, varying in a range of 0.336-0.504 and averaging 0.417. It suggests that the dolomite formed under near-surface conditions. There are two models for the origin of the Carboniferous KT-I dolomite reservoir. These are 1） the evaporation concentration – weathering crust model and 2） the shoal facies – seepage reflux model. The former is mainly developed in restricted platforms – evaporate platforms of restricted marine deposition environments with a representation of dolomite associated with gypsum and mudstone. The latter mainly formed in platform edge shoals and intra-platform shoals and is controlled by dolomitization due to high salinity sea water influx from adjacent restricted sea or evaporate platform.

关键词： Isotope dolomite Carboniferous genetic model eastern margin of Pre-Caspian Basin

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Studies on the genetic model of Nitrogen Uptake by Maize Plants at Their Seedling Stage

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生物数学学报 1997年第1期12卷 44-47页

作者： Cai Yilin He Xiaoyang(Southwest Agricultural University,Chongqing 630716) 西南农业大学重庆 630716 西南农业大学重庆

The genetic model of nitrogen uptake by maize plants at their seedling stage was studied according to the method of augmented NC Ⅱ design and genetic model test proposed by Mo Huidong in *** result showed that the he... 详细信息

关键词： Maize nitrogen uptake genetic model

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Feature,genetic model and distribution of calcareous insulating layers in marine strata of western Pearl River Mouth basin in north of South China Sea

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Journal of Central South University 2020年第11期27卷 3375-3387页

作者： HU Yu ZHANG Ting-shan LIAO Ming-guang ZHU Hai-hua Natural Gas Geology Key Laboratory of Sichuan Province Southwest Petroleum UniversityChengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China Sichuan Key Laboratory of Shale Gas Evaluation and Exploitation Chengdu 610091China

We have systematically investigated the feature, genetic model and distribution of calcareous insulating layers in marine strata of the Ⅰ oil group in member 2 of Zhujiang formation(ZJ2I oil formation), western Pearl River Mouth basin(PRMB) in the north of the South China Sea by using data such as cores, thin sections, X-ray diffraction of whole-rock, and calcite cement carbon and oxygen isotopes. The lithology of the calcareous insulating layers in the study area is mainly composed of the terrigenous clastic bioclastic limestone and a small amount of fine-grained calcareous sandstone. On this basis, two genetic models of calcareous insulating layers are established, including the evaporation seawater genetic model and shallow burial meteoric water genetic model. The calcareous insulating layers of the evaporation seawater genetic model developed in the foreshore subfacies, mainly at the top of the 1-1 strata and 1-3 strata. The calcareous insulating layers of the shallow burial meteoric water genetic model developed in the backshore subfacies, primarily in the 1-2 strata.

关键词： western Pearl River Mouth basin marine strata calcareous insulating layer genetic model

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Analysis of genetic Effects of Nuclear-Cytoplasmic Interaction on Quantitative Traits:genetic model for Diploid Plants

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Journal of genetics and Genomics 2007年第6期34卷 562-568页

作者：韩立德杨剑朱军浙江大学生物信息研究所

A genetic model was proposed for simultaneously analyzing genetic effects of nuclear, cytoplasm, and nuclear-cytoplasmic interaction （NCI） as well as their genotype by environment （GE） interaction for quantitative traits of diploid plants. In the model, the NCI effects were further partitioned into additive and dominance nuclear-cytoplasmic interaction components. Mixed linear model approaches were used for statistical analysis. On the basis of diallel cross designs, Monte Carlo simulations showed that the genetic model was robust for estimating variance components under several situations without specific effects. Random genetic effects were predicted by an adjusted unbiased prediction （AUP） method. Data on four quantitative traits （boll number, lint percentage, fiber length, and micronaire） in Upland cotton （Gossypium hirsutum L.） were analyzed as a worked example to show the effectiveness of the model.

关键词： Plants traits genetic model nuclear-cytoplasmic interaction effects GE interaction genetic prediction

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genetic model for Fresh-keeping Character in Sweet Corn

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Agricultural Science & Technology 2016年第8期17卷 1823-1827页

作者：黄成威陈沛君秦彤非张大伟张永顺蒋锋仲恺农业工程学院农学院广州510225

This study was conducted to investigate the genetic regularity of indexes related to freshness keeping and its molecular basis by acquiring 6 generations （P1, P2, F1, B1, B2 and F2） of an inbred line T3 with long freshness period × an inbred line T15 with short freshness period in sweet corn. The genetic analysis of the indexes was performed by major gene＋polygene mixed genetic model combined with the genetic analysis combining six *** results showed that the decreasing rate of the postharvest sugar content in the T3 was controlled by two pairs of additive-dominante-epistatic major genes＋additive-dominant polygenes; each segregating generation was affected by its major genes, the heritability of major genes and polygene in the B1 generation was 74.63% and 17.67%, respectively; the heritability of major gene and potygene in the B2 was 91.98% and 0,00%, respectively; and the heritability of major gene and polygene inthe F2 was 82.67%, and 12.93%, respectively.

关键词： Sweet corn Fresh keeping genetic model

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A model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information

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Journal of Systems Science & Complexity 2017年第1期30卷 101-110页

作者： HU Xiaonan DUAN Xiaogang PAN Dongdong ZHANG Sanguo LI Qizhai School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049 China KeyLaboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing 100190China. School of Statistics Beijing Normal University Beijing 100875 China. Department of Statistics Yunnan University Kunming 650091 China Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy ofSciences Beijing 100190 China.

The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test.

关键词： genetic model hardy-weinberg equilibrium power robust trend test.

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iGMDR:Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 150-160页

作者： Xiang Chen Yi Guo Xin Chen Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital Department of Radiation Oncology Zhejiang University School of MedicineHangzhou 310058China Department of Polymer Science and Engineering and Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province Zhejiang UniversityHangzhou 310027China Joint Institute for genetics and Genome Medicine between Zhejiang University and University of Toronto Zhejiang UniversityHangzhou 310058China

Current pharmacogenetic studies have obtained many genetic models that can predict the therapeutic efficacy of anticancer *** some of these models are of crucial importance and have been used in clinical practice,these very valuable models have not been well adopted into cancer research to promote the development of cancer therapies due to the lack of integration and standards for the existing data of the pharmacogenetic *** this purpose,we built a resource investigating genetic model of drug response(iGMDR),which integrates the models from in vitro and in vivo pharmacogenetic studies with different omics data from a variety of technical *** this study,we introduced a standardized process for all integrations,and described how users can utilize these models to gain insights into *** is freely accessible at https://***.

关键词： genetic model Pharmacogenetics Anticancer drug Cancer Drug response

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Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson's disease,with insights into Pink1 knockout models

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Zoological Research 2023年第3期44卷 559-576页

作者： Zhangting Wang See-Wing Chan Hui Zhao Kai-Kei Miu Wai-Yee Chan School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and genetics School of Biomedical SciencesThe Chinese University of Hong KongHong Kong SARChina Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesThe Chinese University of Hong KongHong Kong SARChina

Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor *** studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy *** intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation *** such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug *** rats retain clinical features encompassing basal mitophagic flux changes with PD *** demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.

关键词： Parkinson’s disease Mitophagy Inflammatory response genetic model Pink1 KO rats

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genetic association study of P2x7 A1513C(rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1126-1134页

作者： Eyad M.A.Alshammari Raju K.Mandal Mohd Wahid Sajad A.Dar Arshad Jawed Mohammed Y.Areeshi Saif Khan Md.Ekhlaque Ahmed Khan Aditya K.Panda Shafiul Haque Department of Clinical Nutrition College of Applied Medical SciencesUniversity of Ha’il Research and Scientific Studies Unit College of Nursing & Allied Health SciencesJazan University The University College of Medical Sciences & GTB Hospital (University of Delhi) Centre for Life Sciences Central University of Jharkhand

Objective:To summarize the precise association between pulmonary tuberculosis(PTB) and P2x7 A1513 C gene ***:PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513 C polymorphism and PTB risk.A meta-analysis was performed for the selected case-control studies and pooled odds ratios(ORs) and 95%confidence intervals(95%CIs) were calculated for all the genetic ***:Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this *** observed overall no significant risk in all the five genetic *** stratified population by the ethnicity,Caucasian population failed to show any risk of PTB in all the genetics *** Asian ethnicity,variant allele(C vs.A:P=0.001;QR=1.375,95%CI=1.159-1.632) and heterozygous genotype(AC ***:P=0.001;OR=1.570,95%CI=1.269-1.944) demonstrated significant increased risk of ***,recessive genetic model(CC+AC ***:P=0.001;OR=1.540,95%CI= 1.255-1.890) also demonstrated increased risk of PTB in ***:Our meta-analysis did not suggest the association of P2x7 A1513 C polymorphism with PTB risk in overall or separately in Caucasian ***,it plays a significant risk factor for predisposing PTB in *** larger sample and expression studies are needed to validate this association.

关键词： genetic model Meta-analysis Polymorphism P2x7 gene Pulmonary tuberculosis

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genetic Analysis of the Resistance to Aspergillus flavus Infection in Maize (Zea mays L.)

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Agricultural Sciences in China 2009年第6期8卷 761-765页

作者： DENG De-xiang JIANG Si-xia WANG Yi-jun BIAN Yun-long CHEN Jian-jian JIA Bo Jiangsu Province Key Laboratory of Crop genetics and Physiology~Key Laboratory of Plant Functional Genomics Ministry of Education Yangzhou University Yangzhou 225009 P.R. China Yangzhou Environment and Resources Technical College Yangzhou 225009 P.R. China

Maize （Zea mays L.）, one of main crops in the world, is easily susceptible to Aspergillusflavus （Link： fr） infection, resulting huge loses worldwide. Breeding for A. flavus resistance has been proved an efficient way to solve the problem of aflatoxin contamination. genetic analysis of the sources of resistance to *** in maize is necessary for this purpose. The complete diallel crosses of 6 inbred lines with different resistance to *** infection were implemented. Inoculation categorical data of each cross were analyzed with the additive-dominant and additive-dominant-epitasis genetic models. Results indicated some crosses fitted the 2 major genes with additive-dominant-epitasis genetic model. Others fitted the major gene and polygene mixed model. Moreover, the additive, dominant, and epitasis effects varied in crosses. The *** resistance was controlled by both major gene and polygene.

关键词： maize Aspergillus flavus resistance genetic model

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