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Chinese Physics B 2016年第10期25卷 76-88页

作者：柴秀丽甘志华路杨张苗辉陈怡然 School of Computer and Information Engineering Institute of Image Processing and Pattern Recognition Henan University Department of Electrical and Computer Engineering University of Pittsburgh School of Software Henan University Research Department Henan University

Recently, many image encryption algorithms based on chaos have been proposed. Most of the previous algorithms encrypt components R, G, and B of color images independently and neglect the high correlation between them. In the paper, a novel color image encryption algorithm is introduced. The 24 bit planes of components R, G, and B of the color plain image are obtained and recombined into 4 compound bit planes, and this can make the three components affect each other. A four-dimensional(4D) memristive hyperchaotic system generates the pseudorandom key streams and its initial values come from the SHA 256 hash value of the color plain image. The compound bit planes and key streams are confused according to the principles of genetic recombination, then confusion and diffusion as a union are applied to the bit planes,and the color cipher image is obtained. Experimental results and security analyses demonstrate that the proposed algorithm is secure and effective so that it may be adopted for secure communication.

关键词： genetic recombination memristive hyperchaotic system color image encryption confusion diffusion

Allopolyploidization increases genetic recombination in the ancestral diploid D genome during wheat evolution

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The Crop Journal 2022年第3期10卷 743-753页

作者： Hongshen Wan Jun Li Shengwei Ma Fan Yang Liang Chai Zehou Liu Qin Wang Zongjun Pu Wuyun Yang Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina Key Laboratory of Wheat Biology and genetic Improvement on Southwestern China Ministry of Agriculture and Rural AffairsChengdu 610066SichuanChina The Applied Plant Genomics Lab College of Agricultural SciencesNanjing Agricultural UniversityNanjing 210095JiangsuChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina

genetic recombination produces new allelic combinations,thereby introducing variation for *** has increased the evolutionary potential of hexaploid common wheat by conferring the advantages of heterosis and gene redundancy,but whether a relationship exists between allopolyploidization and genetic recombination is currently *** study the impact of allopolyploid ization on genetic recombination in the ancestral D genome of wheat,we generated new synthetic hexaploid wheats by crossing tetraploid Triticum turgidum with multiple diploid Aegilops tauschii accessions,with subsequent chromosome doubling,to simulate the evolutionary hexaploidization *** the DArT-Seq approach,we determined the genotypes of two new synthetic hexaploid wheats with their parents,F;plants in a diploid population(2 x,D_(1)D_(1)×D_(2)D_(2))and its new synthetic hexaploid wheatderived population(6 x,AABBD_(1)D_(1)×AABBD_(2)D_(2)).About 11%of detected SNP loci spanning the D genome of *** were eliminated after allohexaploidization,and the degree of segregation distortion was increased in their hexaploid offspring from the F_(1) *** on codominant genotypes,the mean genetic interval length and recombination frequency between pairs of adjacent and linked SNPs on D genome of the hexaploid F;population were 2.3 fold greater than those in the diploid F_(2) population,and the recombination frequency of *** was increased by their hexaploidization with *** conclusion,allopolyploidization increases genetic recombination of the ancestral diploid D genome of wheat,and DNA elimination and increased segregation distortion also occur after *** genetic recombination could have produced more new allelic combinations subject to natural or artificial selection,helping wheat to spread rapidly to become a major global crop and thereby accelerating the evolution of wheat via hexaploidization.

关键词： Synthetic wheat Hexaploidization Diploid D genome genetic recombination Acceleration of evolution

genetic Analysis of Human Adenovirus Type 7 Strains Circulating in Different Parts of China

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Virologica Sinica 2021年第3期36卷 382-392页

作者： Yali Duan Changchong Li Li Deng Shuhua An Yun Zhu Wei Wang Meng Zhang Lili Xu Baoping Xu Xiangpeng Chen Zhengde Xie Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou 325027China Guangzhou Women and Children's Medical Center Guangzhou 510623China Children's Hospital of Hebei Province Shijiazhuang 050031China

To investigate the molecular epidemiology and genetic variation of human adenovirus type 7(HAdV-7)in children with acute respiratory infections(ARI)in ***-7-positive respiratory samples collected from children with ARI in Beijing,Shijiazhuang,Wenzhou and Guangzhou from 2014–2018 were selected for gene amplification and sequence ***-seven HAdV-7 clinical strains with hexon,penton base and fiber gene sequences were ***17 strains were selected randomly from different cities for whole genome *** and variation analyses were performed based on the obtained sequences,HAdV-7 prototype strain Gomen(AY594255),vaccine strains(AY495969 and AY594256)and representative sequences of *** phylogenetic trees constructed based on whole genome sequences,major capsid protein genes(hexon,penton base and fiber)and the early genes(E1,E2,E3 and E4)were not completely *** HAdV-7 strains obtained in this study always clustered with most of the circulating strains worldwide from the 1980 s to the *** with the HAdV-7 prototype strain Gomen(AY594255),some amino acid mutations in loop1 and loop2 of hexon and the RGD loop region of the penton base gene were *** analysis showed that partial regions of 55 k Da protein and 100 kDa hexon-assembly associated protein genes among all HAdV-7 strains in this study were from HAdV-16 and HAdV-3,*** study demonstrated the molecular evolution characteristics of HAdV-7 strains circulating in China and provided basic reference data for the prevention,control and vaccine development of HAdV-7.

关键词： Human adenovirus type 7(HAdV-7) Genome-wide sequence analysis Mutation genetic recombination

DEVELOPMENT OF geneticALLY ENGINEERED MOUSE/HUMAN CHIMERIC AND SINGLE CHAIN ANTIBODIES AGAINST HUMAN BRAIN GLIOMA:A PRELIMINARY REPORT

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Chinese Journal of Cancer Research 1997年第1期9卷 11-15页

作者：黄强沈树泉许志元 Department Neurosurgery & Brain Tumor Research Laboratory The 2nd Affiliated Hospital Suzhou Medical College Suzhou

In order to improve the clinical usefulness of mAb of mouse origin in targeting diagnosis and therapy for human brain glioma, it is necessary to humanize it and reduce its molecular size. By means of RT-PCR technique, a 348 bp heavy chain variable domain (VH),and a 318 bp light chain variable domain (VL) cDNA fragments were cloned from mouse hybridoma cell line SZ39 secreting mAb against human brain glioma. By recombinant DNA technique, the two cDNA 'fragments were linked to human IgGI heavy chain CHI and light chain K constant regions, respectively, to form a mouse/human chimeric gene which was then inserted into an expression vector pHENI-SZ39 Fab/Hu. In addition,the two cDNA fyagments were linked directly with a universal link6r and inserted into an expression vector pHENI-SZ39ScFv. The two expression vectors were separately introduced into non-suppressor *** HB2151to secrete chimeric antibodies and single-chain antibodies,respectively. On ELISA and Western blot assays, the two genetically engineered antibodies were bound specifically to the same 180 kD cell surface membrane antigen on human brain glioma cell line SHG44 as did the parental mAb SZ39.

关键词： Monoclonal antibody Glioma genetic recombination

Progress of Domestic Recombinant Human-Like Collagen Research and Application

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China Detergent & Cosmetics 2022年第2期7卷 58-62页

作者： Yu Jianjun Zhao Hua Zhejiang Meishangjie Biotech Co. Ltd.China

By intercepting the most effective fragment of human collagen’s gene,recombinant human-like collagen is produced by genetic engineering technology and *** collagen has good biocompatibility and can promote cell *** human-like collagen has great potential application value in medical biological materials,cosmetics and *** recent years,many specialized enterprises which are engaged in human-like collagen raw materials production have *** this paper,a brief summary of the current recombinant human-like collagen raw material’s production and its latest research and development have been made.

关键词： recombinant human-like collagen fibronectin genetic recombination biological fermentation

A review of the recombination events,mechanisms and consequences of Coxsackievirus A6

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Infectious Medicine

Infectious Medicine 2024年第2期3卷 24-35页

作者： Zequn Wang Hongling Wen Department of Microbiological Laboratory Technology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Prevention and Control of Emerging Infectious Diseases Biosafety in Universities of ShandongJinan 250012China

Hand,foot,and mouth disease(HFMD)is one of the most common class C infectious diseases,posing a seri-ous threat to public health *** A71(EV-A71)and coxsackievirus A16(CV-A16)have been regarded as the major pathogenic agents of HFMD;however,since an outbreak caused by coxsackievirus A6(CV-A6)in France in 2008,CV-A6 has gradually become the predominant pathogen in many ***-A6 infects not only children but also adults,and causes atypical clinical symptoms such as a more generalized rash,eczema herpeticum,high fever,and onychomadesis,which are different from the symptoms associated with EV-A71 and ***,the rate of genetic recombination of CV-A6 is high,which can lead to changes in virulence and the rapid evolution of other characteristics,thus posing a serious threat to public *** date,no specific vaccines or therapeutics have been approved for CV-A6 prevention or treatment,hence it is essential to fully understand the relationship between recombination and evolution of this ***,we systematically review the genetic recombination events of CV-A6 that have occurred worldwide and explore how these events have promoted virus evolution,thus providing important information regarding future HFMD surveillance and prevention.

关键词： genetic recombination CV-A6 Virus evolution Enterovirus HFMD