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Expression Patterns of the Cell Junction-associated genes During Rat Liver Regeneration

Journal of Genetics and Genomics 2007年第10期34卷 892-908页

作者：李红蕾陈晓光张富春马纪徐存拴新疆大学生命科学与技术学院河南师范大学生命科学学院新乡453007

To study actions of the genes associated with tight junction, adherent junction, focal adhesion, and gap junction during liver regeneration （lr）, these genes were obtained by collecting data from databases and thesis, and their expression profiles in rat regenerating liver were detected employing Rat Genome 230 2.0 array. Next the lr-associated genes were identified by comparing the difference between sham operation （SO） and partial hepatectomy （PH） groups. 79, 53, 109, 53 genes involved in the above four junctions were found to be lr-associated. The initial and total expression numbers of these genes occurring in the initial phase of lr, G0/G1, cell proliferation, cell differentiation, and structure-functional rebuilding were 124, 43, 122, 10, and 249, 145, 957, 306, respectively, illustrating that genes were initi^ly expressed mainly in the initiation stage, and functioned in different phases. Up-regulation-and down-regulation to a total of 972 and 540 times, as well as, 41 types of expression patterns showed that the physiological and biochemical activities were diverse and complicated in lr. According to the data, there was an increase in the forepart and prophase, but a decrease in late-metaphase and anaphase for gap junction assembly. Focal adhesion formation displayed an enhancement in forepart, prophase, and anaphase; and formation of tight junctions and adherent junctions last throughout the lr.

关键词： partial hepatectomy (PH) rat genome 230 2.0 array cell junction genes associated with lr

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