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The NAC transcription factor LuNAC61 negatively regulates fiber development in flax (Linum usitatissimum L.)

Journal of Integrative Agriculture 2024年第3期23卷 795-805页

作者： Dongwei Xie Jing Li Wan Li Lijun Sun Zhigang Dai Wenzhi Zhou Jianguang Su Jian Sun School of Life Sciences Nantong UniversityNantong 226019China Institute of Crop Cultivation and Tillage Heilongjiang Academy of Agricultural SciencesHarbin 150086China Institute of Bast Fiber Crops Chinese Academy of Agricultural SciencesChangsha 410221China Jiangsu Sanshu Biotechnology Co.Ltd. Nantong 226001China

Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(NAM, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. Subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield.

关键词： flax fiber development Lu NAC61 gene function gene interaction

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Role of a Signalling System in gene interaction in Inheritance of Root System Characteristics of Arabidopsis thaliana (L.) Heynh.

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Open Journal of genetics 2016年第3期6卷 51-60页

作者： Sergei Hablak Lugansk National Agrarian University Kharkiv Ukraine

The central problem of genetics is gene interaction since genes in the course of individual organism development interact with other genes, that’s why their effects may change. Studies for the last 100 years managed to discover that the entire diversity of inter-gene interactions is presented in four major forms: complementarity, epistasis, polymery, and modifying effect of genes. However, gene interaction mechanism which is reflected on the segregation nature of variously crossed hybrids has not been sufficiently studied. Exclusive of molecular genetics, biochemistry and physiology, a genetic analysis of inheritance of characteristics in gene interaction taken by itself cannot reveal nature of this interaction. Lately, molecular-genetic and physiological studies on A. thaliana mutants have enabled to isolate and sequence a wide range of genes controlling certain links of the signalling chain. At the same time, effect of the plant development regulation signalling system on interaction of these genes in inheritance of characteristics of Arabidopsis root system haven’t been studied so far which was a cause for our studies. gene interaction problem is closely related to the plant development regulation signalling system. Mechanism involved in gene interaction may be explained based on current idea of molecular principles of biological response. Affected by mutations occurring in various genes that control certain links of the signalling chain, signalling path to the cell nucleus and response are blocked partially or in full which leads to distortion in expression of the characteristic on the plant level in general or its organ level. Such phenomenon is observed in realization of many characteristics in animals and plants, including in A. thaliana. In inheritance of such characteristics, as a rule, both allelic, and non-allelic gene interactions are observed. Results of a study of the plant signalling system interconnection and gene interaction in inheritance of characteristics of Arabidopsis root system are present

关键词： Arabidopsis thaliana (L.) Heynh. Root System gene Mutation gene interaction Signalling System

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Three co-located resistance genes confer resistance to leaf rust and stripe rust in wheat variety Borlaug 100

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The Crop Journal 2022年第2期10卷 490-497页

作者： Bowei Ye Ravi P.Singh Chan Yuan Demei Liu Mandeep S.Randhawa Julio Huerta-Espino Sridhar Bhavani Evans Lagudah Caixia Lan College of Plant Science&Technology Huazhong Agricultural UniversityWuhan 430070HubeiChina International Maize and Wheat Improvement Center(CIMMYT) Apdo.Postal 6-64106600 Mexico D.F.Mexico Qinghai Provincial Key Laboratory of Crop Molecular Breeding Northwest Institute of Plateau BiologyChinese Academy of ScienceXining 810008QinghaiChina Campo Experimental Valle de México INIFAP Apdo.Postal 1056230ChapingoEdo.de MexicoMexico CSIRO Agriculture&Food GPO Box 1600CanberraACT 2601Australia

Leaf rust(LR) and stripe rust(YR) are important diseases in wheat producing areas worldwide and cause severe yield losses under favorable environmental conditions when susceptible varieties are grown. We determined the genetic basis of resistance to LR and YR in variety Borlaug 100 by developing and phenotyping a population of 198 F6 recombinant inbred lines derived from a cross with the susceptible parent Apav#1. LR and YR phenotyping were conducted for 4 and 3 seasons, respectively, at CIMMYT research stations in Mexico under artificial epidemics. Mendelian segregation analyses indicated that 3–5 LR and 2 YR genes conferred resistance in Borlaug 100. Lr46/Yr29(1 BL), Yr17(2 AS) and Yr30(3 BS) were present in the resistant parent and segregated in the RIL population based on characterization by molecular markers linked to these genes. When present alone, Lr46/Yr29 caused average 13% and 16% reductions in LR and YR severities, respectively, in RILs. Similarly, Yr17 and Yr30 reduced YR severities by 57% and 11%, respectively. The Yr30 and the Yr17 translocation were also associated with 27% and 14% reductions, respectively, in LR severity, indicating that the 3 BS and 2 AS chromosomal regions likely carry new slow rusting LR resistance genes, temporarily designated as Lr B1 and Lr B2, respectively. Additive effects of Yr30*Yr17, Yr29*Yr17 and Yr29*Yr30 on YR and LR were significant and reduced YR severities by 56%,55%, and 45%, respectively, and LR severities by 34%, 40%, and 45%, respectively. Furthermore, interaction between the three genes was also significant, with mean reductions of 70% for YR and 54% for LR severities. Borlaug 100, or any one of the 21 lines with variable agronomic traits but carrying all three colocated resistance loci, can be used as resistance sources in wheat breeding programs.

关键词： Co-located resistance loci Common wheat gene interaction Puccinia triticina Puccinia striiformis Triticum aestivum

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interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients

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World Journal of Gastroenterology 2010年第2期16卷 176-183页

作者： Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh Department of Medical genetics University of Pécs Department of Medicine and Gastroenterology Markusovszky Hospital 3rd Department of Internal Medicine University of Pécs 3rd Department of Medicine and Gastroenterology Réthy Pál Hospital

AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;Pinteraction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci.

关键词： gene interaction Interleukin-23 receptor Autophagy-related 16-like 1 IBD5 Caspase recruitment domain-containing protein 15 Crohn’s disease Inflammatory bowel disease

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Annexin A2 Regulates the Levels of Plasmin,S100A10 and Fascin in L5178Y Cells

Annexin A2 Regulates the Levels of Plasmin,S100A10 and Fasci...

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中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者： Ying-Chun Hou~1 Yang Hou~(2**) Li-Juan Yang~(3**) Mao-Sen Mu~(1**) Ai-Ran Zhang~1 Ning Pan~1 Rong-Bin Qiang~1 1 Department of Cell Biology,School of Life Sciences,Shaanxi Normal University,Xi’an 710062,China 2 Changzheng Hospital,Shanghai 200003,China 3 The general Hospital of PLA,Beijing 100853,China

As an important member of annexin family,annexin A2(ANXA2)has been proved to play some important roles in the development of some human diseases,for examples,heart and cardiovascular diseases,disorders of hemoagglutin... 详细信息

关键词： annexin A2 gene knockout gene interaction tumor cells

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Dissection of Developmental Mechanisms of Neurocristopathy in Waardenburg Syndrome and Piebaldism Mouse Models

Dissection of Developmental Mechanisms of Neurocristopathy i...

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第二届全国发育生物学大会

作者： Ling Hou Developmental Cell Biology and Disease Program Vision Science Research CenterWenzhou Medical University

Many human neurocristopathies include genetic defects in a number of syndromes,tumors,and dysmorphologies of neural crest stem cell derivatives during development.Mouse coat color mutations have long served as an excellent model for the study of neural crest stem cell developmental genetics.Due to shared embryonic origin of various tissues or to pleiotropic effects,these mutants also serve as human disease models for many aspects of studies including vision,hearing,craniofacial abnormalities,digestive disorders,and neural tube defects.In recent years a complex network of genes has been associated with pigmentation abnormalities and deafness in neurocristopathies resulting from NC stem cell-derived melanocyte deficiency.For example,Waardenburg syndrome(WS)can result from mutations either in SoxlO,Mitf or Ednrb and Piebaldism can result from mutations in Kit.Recent studies have revealed surprising new insights into how this network of interacting genes plays complex functional roles in melanocyte development.Currently,we are using Waardenburg Syndrome and Piebaldism mouse models to dissect developmental mechanisms of neurocristopathy.In this point of view,I will provide some of our findings and explore potential mechanisms by which this regulatory network of interacting genes may control melanocyte precursor differentiation.

关键词： genetic disease neural crest stem cell gene interaction melanocyte differentiation

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