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Exploring the potential mechanisms of luteolin against ulcerative colitis and colorectal cancer via network pharmacology and molecular docking

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TMR Integrative Medicine 2023年第26期7卷 1-11页

作者： Qiang Zhang Shuang Liu Zi-Ye Li Yu-Jie Shang Larwubah Kollie Zong-Suo Liang College of Life Sciences Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China College of Life Sciences Northwest A&F UniversityYangling 712100China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410078China

Background:Patients diagnosed with ulcerative colitis(UC)are known to have an increased susceptibility to colorectal cancer(CRC).However,the shared underlying mechanisms between UC and CRC remain *** the therapeutic potential of luteolin in both UC and CRC,this study aims to elucidate the molecular targets and mechanisms through which luteolin exerts its effects against these ***:The geneCards database,Disgenet database,and gene Expression Omnibus database were utilized to analyze the targets associated with UC and ***,the Traditional Chinese Medicine Systems Pharmacology and SwissTargetPrediction databases were employed to identify luteolin-related *** identified luteolin-related targets were then mapped to official gene symbols using the UniProt *** Cytoscape 3.9.0 software was utilized to construct a network of luteolin-associated *** diagram analysis was performed to identify common targets among UC,CRC,and *** common targets were further analyzed using the STRING database to construct a protein-protein interaction ***“cytoHubba”plugin in Cytoscape 3.9.0 was employed to identify hub targets within the PPI *** Ontology functional analysis and Kyoto Encyclopedia of genes and Genomes pathway enrichment analysis were conducted on the hub ***,molecular docking using AutoDock and PyMOL software was performed to assess the binding affinity between luteolin and the hub ***:Luteolin was found to interact with a total of 149 pharmacological targets,while UC and CRC were associated with 1232 and 3278 targets,***-six common targets were identified among luteolin,UC,and *** the application of seven different algorithms,seven hub targets were identified,TP53,AKT1,TNF,SRC,EGFR,and *** enrichment analysis revealed 49 enriched pathways through Kyoto Encyclopedia of genes and Genomes analysis,while gene Ontology analysis yielded a

关键词： ulcerative colitis colorectal cancer luteolin network pharmacology gene enrichment

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