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gastroprotective herbs for headache management in Persian medicine:A comprehensive review

Journal of Integrative Medicine 2020年第1期18卷 1-13页

作者： Maryam Naeimi Narjes Gorji Zahra Memariani Reihaneh Moeini Mohammad Kamalinejad Fatemeh Kolangi Department of Persian Medicine School of Persian MedicineBabol University of Medical SciencesBabol ***Iran Traditional Medicine and History of Medical Sciences Research Center Health Research InstituteBabol University of Medical SciencesBabol ***Iran School of Pharmacy Shahid Beheshti University of Medical SciencesTehran ***Iran Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical SciencesGorgan ***Iran

The gut-brain axis is a bidirectional communication system that exists between the brain and gut. Several studies claimed that some types of headaches are associated with various gastrointestinal(GI) *** Persian medicine(PM), physicians believed that gastric disturbances could stimulate headache and introduced some herbs for boosting gastric function as a therapeutic remedy for headache. Here we review the current evidence for the gastroprotective and antiheadache effects of herbs used in *** used for their gastrotonic effects in PM were identified from selected Persian medical and pharmaceutical textbooks. Pub Med, Scopus and Google Scholar were used to search for contemporary scientific evidence relating to the gastric and neurologic effects of these plants. A total of 24 plants were recorded from the selected sources included in this review, most of which belonged to the Rosaceae *** emblica, Zingiber officinale, Boswellias errata, Punica granatum and Hypericum perforatum had the most recent studies related to GI disorder and headache, while current research about quince, rose,apple, hawthorn and pear was limited. Reducing Helicobacter pylori growth, gastritis, erosion of the stomach lining, hemorrhage and perforation, improving gastric mucosal resistance, antisecretary, antiulcer,antipyretic, analgesic, sedative, anxiolytic, anti-inflammatory, anticonvulsant, neuroprotective and antioxidant effects as well as improvement in memory scores were some of the gastrotonic and neuroprotective mechanisms described in the current research. These results confirmed that medicinal plants prescribed in PM may improve headache in patients through the management of GI ***, further studies are recommended to investigate the efficacy and safety of the mentioned medicinal plants.

关键词： Traditional medicine Gastrointestinal diseases Headache gastroprotective agent

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gastroprotective effect of Achyranthes aspera Linn,leaf on rats

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Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 197-201页

作者： Ashish K Das Papiya Bigoniya Neelesh K Verma AC Rana Department of Pharmacology Radharaman College of PharmacyBhopal-02M.P.India Rayat College of Pharmacy Rail Majranear Ropar NawanshahrPunjabIndia

Objective:The study was aimed al evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera(EEAA) ***:The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer *** effects of the EEAA on gastric content volume,*** acidity,total acidity and ulcer index were ***:The percentage of ulcer protection(59.55%and 35.58%) was significantly(P gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids,saponins and tannins.

关键词： Antiulcer Achyranthes aspera gastroprotective Omeprazole Ethanol

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Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 598-603页

作者： Monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De Marino Hichem Ben Jannet Abderrahman Bouraoui Laboratoire de développement chimique galénique et pharmacologique des médicaments (LR12ES09).Equipe de Pharmacologie marineFaculté de pharmacie de MonastirUniversité de Monastir Department of Pharmacy University of Naples "Federico II" Laboratoire de chimie hétérocyclique produits naturels et réactivité. Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir Laboratoire de chimie hétérocyclique produits naturels et réactivité.Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.

关键词： Eunicella singularis Anti-inflammatory activity Analgesic activity gastroprotective effect Diterpenoid Sterols

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Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: role of α-pinene

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Journal of Traditional Chinese Medicine 2017年第1期37卷 57-63页

作者： Zahra Memariani Mohammad Sharifzadeh Mahbubeh Bozorgi Mannan Hajimahmoodi Mohammad Hosein Farzaei Mahdi Gholami Farideh Siavoshi Parastoo Saniee Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Research Center of Traditional Medicine and History of Medical Sciences Babol University of Medical SciencesMazandaran ***Iran Department of Pharmacology and Toxicology Faculty of Pharmacyand Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehran ***Iran Department of Drug and Food Control Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Faculty of PharmacyKermanshah University of Medical SciencesKermanshah ***Iran Medical Biology Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Department of Microbiology School of BiologyUniversity College of SciencesUniversity of TehranTehran ***Iran

OBJECTIVE: To evaluate the efficacy of Pistacia atlantica Desf. oleoresin essential oil on peptic ulcer(PU) and its antibacterial effect on metronidazole-resistant Helicobacter pylori, as well as chemi-cal composition of the essential ***: The essential oil was standardized using gas chromatography mass spectrometry(GC/MS) analysis. Acute toxicity of the essential oil was assessed in animal model. In vitro anti-Helicobacter pylori activity was performed through disc diffusion and minimum inhibitory concentration method. For gastroprotective assay, rats received Pistacia atlantica Desf. essential oil(25, 50 and 100 mg/kg orally) 1 h before induction of ulcer by ***(ulcer index and protection rate) and microscopic examination were ***: The GC/MS analysis of the essential oil led to the identification of twenty constituents andα-pinene is predominant constituent. The essential oil was safe up to 2000 mg/kg. All Helicobacter pylori strains were susceptible to the essential oil and the MIC ranged from 275 to 1100 μg/m L. The ulcer index for treated groups was significantly reduced compared to control(P < 0.001) with EC50 value of 12.32 mg/kg. In microscopic examination, Pistacia atlantica attenuated destruction and necrosis of gastric ***: Current study exhibited protective effect of standardized Pistacia atlantica essential oil against ethanol-induced gastric ulcer and its antibacterial activity on Helicobacter pylori. α-pinene might be the responsible agent.

关键词： Peptic ulcer Pistacia Oils volatile Oleoresins gastroprotective Helicobacter pylori Medicine traditional

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Cumin(Cuminum cyminum)and black cumin(Nigella sativa)seeds:traditional uses,chemical constituents,and nutraceutical effects

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Food Quality and Safety 2018年第1期2卷 1-16页

作者： Krishnapura Srinivasan Department of Biochemistry CSIR-Central Food Technological Research InstituteMysoreIndia

Although the seeds of cumin(Cuminum cyminum L.)are widely used as a spice for their distinctive aroma,they are also commonly used in traditional medicine to treat a variety of *** literature presents ample evidence for the biomedical activities of cumin,which have generally been ascribed to its bioactive constituents such as terpenes,phenols,and *** health effects of cumin seeds that are experimentally validated are discussed in this *** seeds(Nigella sativa),which are totally unrelated to ***,have nevertheless taken the name‘Black cumin’and used in traditional systems of medicine for many *** pre-clinical and clinical trials have investigated its efficacy using the seed oil,essential oil,and its main constituent thymoquinone(TQ).These investigations support its use either independently or as an adjunct along with conventional drugs in respiratory problems,allergic rhinitis,dyspepsia,metabolic syndrome,diabetes mellitus,inflammatory diseases,and different types of human *** studies made in the last decades validate its health beneficial effects particularly in diabetes,dyslipidemia,hypertension,respiratory disorders,inflammatory diseases,and *** sativa seeds also possess immune stimulatory,gastroprotective,hepatoprotective,nephroprotective,and neuroprotective *** is the most abundant constituent of volatile oil of *** seeds,and most of the medicinal properties of *** are attributed mainly to *** the available evidence suggests that TQ should be developed as a novel drug in clinical trials.

关键词： Cuminum cyminum Nigella sativa digestive stimulant antidiabetic anti-inflammatory cancer preventive immune stimulatory gastroprotective

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Synthesis and Evaluation of Glyceride Prodrugs of Naproxen

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Open Journal of Medicinal Chemistry 2013年第3期3卷 87-92页

作者： Vivekkumar K. Redasani Sanjay B. Bari H. R. Patel Institute of Pharmaceutical Education and Research Shirpur India R. C. Patel Institute of Pharmaceutical Education and Research Shirpur India

The glyceride ester derivatives 6a and 6b were prepared by reacting 1,2,3-trihydroxy propane 1,3-dipalmitate/stearate with (S)-naproxen as potential prodrugs. The synthesis was achieved successfully with the aid of N,N’-dicyclohexyl- carbodiimide. These prodrugs were evaluated for anti inflammatory, analgesic and gastroprotective activity. It was found that prodrugs 6a and 6b showed less irritation to gastric mucosa as indicated by ulcer index. The synthesized glyceride esters were found to possess good pharmacological profile as shown by results of anti inflammatory and analgesic activity. The aqueous studies were performed in order to ensure the release of prodrugs. Both prodrugs were found to stable at acidic pH while undergoes hydrolysis at pH 7.4. These findings suggest that the glyceride prodrugs 6a and 6b might be used as potential biolabile derivatives.

关键词： Naproxen Glyceride Prodrugs Anti-Inflammatory Analgesic gastroprotective Hydrolysis Kinetics

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An open-label,randomized,cross-over bioequivalence study of lafutidine 10 mg under fasting condition

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第5期1卷 112-118页

作者： Bhupesh Dewan Raghuram Chimata Director Medical Services Zuventus Healthcare Ltd. Mumbai 400072 India Clinical Research Associate Zuventus Healthcare Ltd. Mumbai 400072 India

AIM:To assess the relative bioavailability and pharmacokinetic properties of two formulations(test and reference) of Lafutidine 10 ***:The study was performed as an open label,randomized,two-way,two-period,two-treatment,single dose cross-over bioequivalence study,under non-fed condition to compare the pharmacokinetic prof iles of the lafutidine formulation manufactured by Emcure Pharmaceuticals Ltd.,India using an indigenously developed active pharmaceutical ingredient(API) and the commercially available Stogra formulation,of UCB Japan Co.,Ltd.,*** two treatments were separated by a washout period of 5 *** an overnight fasting period of 10 h,the subjects were administered either the test or the reference medication as per the randomization *** samples were collected at intervals up to 24 h,as per the approved *** of lafutidine in plasma were analyzed by a validated liquid chromatography/tandem mass spectrometry(LC/MS/MS) method,and a non-compartmental model was used for pharmacokinetic *** pharmacokinetic parameters were subjected to a 4-way ANOVA accounting for sequence,subjects,period and *** significance was evaluated at 95% conf idence level(P ≥ 0.05).RESULTS:The mean(±SD) values of the pharmacokinetic parameters(test vs reference) were Cmax(265.15±49.84 ng/mL vs 246.79±29.30 ng/mL,P<0.05),Area under the curve(AUC)(0-t)(1033.13±298.74 ng.h/mL vs 952.93±244.07 ng.h/mL,P < 0.05),AUC(0-∞)(1047.61±301.22 ng.h/mL vs 964.21±246.45 ng.h/mL,P<0.05),and tv2(1.92±0.94 h vs 2.05±1.01 h,P<0.05).The 90% conf idence intervals(CI) for the test/reference ratio of mean Cmax,AUC(0-t),and AUC(0-∞) were within the acceptable range of 80.00 to *** mean times(± SD) to attain maximal plasma concentration(tmax) of lafutidine were 0.95±0.24 h vs 1.01±0.29 h(P<0.05) for the test and the reference formulations *** the formulations were well tolerated.

关键词： Liquid chromatography/tandem mass spectrometry Lafutidine gastroprotective Pharmacokinetics Bioequivalence

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