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Effect of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors

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Journal of Traditional Chinese Medicine 2016年第4期36卷 450-455页

作者： Hou Lili Xu Lei Shi Yan Gu Fen Department of Nursing Shanghai Pulmonary Hospital Department of Nursing Putuo HospitalShanghai University of Traditional Chinese Medicine Department of Nursing Tenth People's Hospital of Tongji University Respiratory Department Shanghai Pulmonary Hospital

OBJECTIVE:To evaluate the effects of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors,and to explore an efficient and noninvasive method for postoperative recovery of bowel functions.METHODS:Forty patients were randomly and evenly assigned into a regular nursing care group(RNC) and an acupoint electric stimulation group(AES).Patients in the RNC group received regular nursing care and patients in the AES group received regular nursing care plus electric stimulation of acupoints.The serum levels of gastrin(GAS),motilin(MOT),and cholecystokinin(CCK),and an electrogastrogram(EGG) of all the patients were evaluated on the first,third,and fifth day after surgery.The time to first flatus after surgery and the number of patients with side effects such as abdominal pain,abdominal distention,and diarrhea were recorded.RESULTS:There were significant differences between the two groups in GAS,MOT,EGG,time to first flatus,abdominal pain,abdominal distention,and diarrhea(P gastrointestinal functions,and decrease complications among postoperative senile patients with gastrointestinal tumors.

关键词： Electric stimulation therapy Aged Gas trointestinal stromal tumors gastrointestinal hor mones gastrointestinal motility Point ST36(Zusan li) Point ST37(Shangjuxu)

Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice

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World Journal of Gastroenterology 2010年第6期16卷 703-712页

作者： Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels Laboratory of Experimental Medicine and Pediatrics Division of GastroenterologyUniversity of Antwerp Division of Infectious Diseases and Immunology Queensland Institute of Medical Research 4006 Brisbane Division of Gastroenterology-Hepatology Tufts New England Medical Center

AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.

关键词： Schistosoma mansoni Helminth proteins Colitis Peristalsis Crohn’s disease gastrointestinal motility Trinitrobenzene sulphate

Neuromechanism of acupuncture regulating gastrointestinal motility

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World Journal of Gastroenterology 2020年第23期26卷 3182-3200页

作者： Zhi Yu Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Acupuncture has been used in China for thousands of years and has become more widely accepted by doctors and patients around the world. A large number of clinical studies and animal experiments have confirmed that acupuncture has a benign adjustment effect on gastrointestinal(GI) movement;however, the mechanism of this effect is unclear, especially in terms of neural mechanisms, and there are still many areas that require further exploration. This article reviews the recent data on the neural mechanism of acupuncture on GI movements. We summarize the neural mechanism of acupuncture on GI movement from four aspects: acupuncture signal transmission, the sympathetic and parasympathetic nervous system, the enteric nervous system, and the central nervous system.

关键词： Acupuncture gastrointestinal motility Neuromechanism Afferent fibers Autonomic nervous system Central nervous system

Ion channel mechanism of gastrointestinal motility and gastric hypersensitivity in functional dyspepsia:a review

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Gastroenterology & Hepatology Research 2022年第3期4卷 23-29页

作者： Terigele Bao Feng Lan Guorui Li Xiyele Mu Ta Na Minghai Fu Yongsheng Chen School of Mongolian Medicine Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina School of Life Sciences Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina

Functional dyspepsia(FD)is a regularly diagnosed clinical gastrointestinal ailment with a high incidence rate that can considerably impact patients’health and quality of life and impose a substantial financial burden.Modern research on the pathophysiology of functional dyspepsia has not thoroughly explained the underlying reasons.The condition does not manifest any significant organ abnormalities,which raises the disease’s difficulty coefficient.Major pathogenic exceptions in FD include gastrointestinal motor dysfunction,gastrointestinal hormone secretion problem,visceral hypersensitivity,and brain-gut axis.Several ion channels have reportedly been implicated in the pathophysiological process of FD.Therefore,it is crucial to comprehend the probable activities of various ion channels in FD.This study focuses on the current state of research on the possible role of several ion channels in the pathogenesis of FD.

关键词： functional dyspepsia ion channel gastrointestinal motility gastric hypersensitivity smooth muscle

Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats

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World Journal of Gastroenterology 2016年第25期22卷 5761-5768页

作者： Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda Sao Paulo State University BotucatuSP 18618-970Brazil Instituto de Ciencias Biologicas e da Saude Federal University of Mato GrossoBarra do GarcasMT 78600-000Brazil Universidade Estadual de Ciencias da Saude de Alagoas MaceioAL 57010-300Brazil Sao Paulo University Ribeirao PretoSP 14049-900Brazil

AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying.

关键词： Reproductive physiological process Sex hormones gastrointestinal motility Magnetic fields Gastric emptying

Electroacupuncture Alleviates Functional Constipation in Mice by Activating Enteric Glial Cell Autophagy via PI3K/AKT/mTOR Signaling

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Chinese Journal of Integrative Medicine 2023年第5期29卷 459-469页

作者： WANG Lu CHEN Ying XU Ming-min CAO Wei ZHENG Qian-hua ZHOU Si-yuan YAO Jun-peng XI Meng-han QIN Hai-yan LI Ying ZHANG Wei Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Traditional Chinese Medicine Jinan UniversityGuangzhou(510632)China

Objective: To investigate autophagy-related mechanisms of electroacupuncture(EA) action in improving gastrointestinal motility in mice with functional constipation(FC). Methods: According to a random number table, the Kunming mice were divided into the normal control, FC and EA groups in Experiment Ⅰ. The autophagy inhibitor 3-methyladenine(3-MA) was used to observe whether it antagonized the effects of EA in Experiment Ⅱ. An FC model was established by diphenoxylate gavage. Then the mice were treated with EA stimulation at Tianshu(ST 25) and Shangjuxu(ST 37) acupoints. The first black stool defecation time, the number, weight, and water content of 8-h feces, and intestinal transit rate were used to assess intestinal transit. Colonic tissues underwent histopathological assessment, and the expressions of autophagy markers microtubuleassociated protein 1 light chain 3(LC3) and Beclin-1 were detected by immunohistochemical staining. The expressions of phosphoinositide 3-kinases(PI3K)-protein kinase B(AKT)-mammalian target of rapamycin(m TOR) signaling pathway members were investigated by Western blot and quantitative reverse transcription-polymerase chain reaction, respectively. The relationship between enteric glial cells(EGCs) and autophagy was observed by confocal immunofluorescence microscopy, localization analysis, and electron microscopy. Results: EA treatment shortened the first black stool defecation time, increased the number, weight, and water content of 8-h feces, and improved the intestinal transit rate in FC mice(Pmotility in FC mice was blocked by 3-MA. Conclusion: EA treatment can inhibit PI3K/AKT/m TOR signaling in t

关键词： electroacupuncture gastrointestinal motility autophagy enteric glial cells Chinese medicine

Efficacy of Qihuang decoction(芪黄煎剂) on enteric nervous system in rats after gastrectomy

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Journal of Traditional Chinese Medicine 2022年第4期42卷 556-564页

作者： ZHANG Qi ZHENG Zhou HUANG Long PENG Hui YU Qingsheng WANG Laiyong Department of General Surgery First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China Institute of Chinese Medicine Surgery Anhui Academy of Traditional Chinese MedicineHefei 230031China

OBJECTIVE:To investigate the influence of Qihuang decoction(芪黄煎剂)on enteric nervous system after gastrectomy in rats.METHODS:The morphology,distribution and number of intestinal neurons in enteric nervous system(ENS)were observed by immunofluorescence labeling and confocal laser scanning microscopy.Reverse transcriptionpolymerase chain reaction and Western blot were used to detect the mRNA and protein expression of intestinal neurotransmitters and corresponding receptors in ENS.RESULTS:The morphology and distribution of enteric neurons in ENS were changed after gastrectomy,and these neurons in Qihuang decoction group were similar with that of sham operation group.The number of ACh and SP positive neurons,mRNA and protein expression of excitatory neurotransmitters(ACh E,SP)and receptors(M3R,NK1R)were decreased after gastrectomy.And the intervention of Qihuang decoction could increase the number of ACh and SP positive neurons and promote the expression of their mRNA and protein.For vasoactive intestinal peptide(VIP)and nitric oxide synthase(NOS),the number of neurons and mRNA and protein expression of inhibitory neurotransmitters(VIP and NOS)and receptors(VIP2R)were increased after gastrectomy.And these rising indexes fall back after the intervention of Qihuang decoction.Besides,the intestinal propulsion rate in QH group was significantly increased than that in SEN and IEN group.CONCLUSIONS:These experimental results showed that after gastrectomy,early intervention with Qihuang decoction in small intestine will contribute to the postoperative recovery of enteric nervous system and intestinal propulsion rate,and consequently enhance gastrointestinal motility.

关键词： Gastrectomy gastrointestinal motility enteric nervous system neurotransmitter agents receptors,neurotransmitter Qihuang decoction

Da-Cheng-Qi Decoction(大承气汤)Combined with Lactobacillus Acidophilus Improves gastrointestinal Function of Traumatic Brain-Injured Model Mice

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Chinese Journal of Integrative Medicine 2020年第10期26卷 762-768页

作者： FU Shao-li ZHU Li-na YIN Hua-hua JIANG Yan ZHU Jing-ci Department of Nursing School of NursingThird Military Medical UniversityChongqing(400038)China Orthopedics Department of Chongqing Traditional Chinese Medicine Hospital Chongqing(400021)China

Objective To investigate the effects of Da-Cheng-Qi Decoction(DCQD,大承气汤)combined with Lactobacillus acidophilus(LA)on the recovery of gastrointestinal(GI)function in traumatic brain-injured(TBI)mice.Methods A total of 150 male C57BL/6 mice were randomly divided into sham-injury,normal saline(NS),DCQD(0.4 mL/day),LA(⩾1×1010 cfu/day LA),DCQD+LA(LA administration at the same dosage after 4 h of feeding DCQD),and½DCQD+LA groups(LA administration at the same dosage after 4 h of feeding½DCQD dose)by a random number table,5–8 mice in each group.The sever TBI model was constructed according to Feeney’s enhanced gravitational forces of free falling.On days 1,3,and 7 post-TBI,plasma diamine oxidase(DAO)and D-lactic acid levels were assessed by enzyme-linked immunosorbent assay(ELISA).Occludin expression in the intestinal epithelium was assessed by Western blot analysis.Transmission electron microscopy(TEM)was used to observe the morphological changes in the network structure of interstitial cells of Cajal(ICC)and change of enteric nervous system-ICC-smooth muscle cell(ENS-ICC-SMC).Immunofluorescence staining was used to detect changes in the network structure of the ICC.Results Compared with the NS group,occludin expression in the DCQD+LA group significantly increased on Day 1,3,and 7 post-TBI(Pmotility in mice after TBI.The combination of DCQD and LA was more effective than their respective monotherapies.

关键词： traumatic brain-injury Da-Cheng-Qi Decoction Lactobacillus acidophilus intestinal mucosal barrier gastrointestinal motility

Electro-acupuncture to prevent prolonged postoperative ileus:A randomized clinical trial

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World Journal of Gastroenterology 2010年第1期16卷 104-111页

作者： M Kay Garcia Joseph S Chiang Bob Thornton J Lynn Palmer Jennifer McQuade Lorenzo Cohen Department of Anesthesiology and Pain Medicine/Integrative Medicine M.D.Anderson Cancer CenterThe University of Texas Department of Anesthesiology and Pain Medicine M.D.Anderson Cancer CenterThe University of Texas Department of Palliative Care and Rehabilitation Medicine M.D.Anderson Cancer CenterThe University of Texas Department of Behavioral Science M.D.Anderson Cancer CenterThe University of Texas Department of GI Medical Oncology M.D. Anderson Cancer CenterThe University of Texas

AIM:To examine whether acupuncture can prevent prolonged postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. METHODS:Ninety patients were recruited from the Fudan University Cancer Hospital,Shanghai,China. After surgery,patients were randomized to receive acupuncture(once daily,starting on postoperative day 1, for up to six consecutive days)or usual care.PPOI was defined as an inability to pass flatus or have a bowel movement by 96 h after surgery.The main outcomes were time to first flatus,time to first bowel movement, and electrogastroenterography.Secondary outcomes were quality of life(QOL)measures,including pain, nausea,insomnia,abdominal distension/fullness,and sense of well-being. RESULTS:No significant differences in PPOI on day 4 (P=0.71)or QOL measures were found between the groups.There were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5(P=0.69)or day 6(P= 0.88).No adverse events related to acupuncture were reported. CONCLUSION:Acupuncture did not prevent PPOI andwas not useful for treating PPOI once it had developed in this population.

关键词： Acupuncture gastrointestinal motility gastrointestinal disorders gastrointestinal neoplasms