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Screening for gastric cancer in China:Advances,challenges and visions

Chinese Journal of Cancer Research 2021年第2期33卷 168-180页

作者： Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Cancer EpidemiologyPeking University Cancer Hospital&InstituteBeijing 100142China

Gastric cancer(GC)is one of the major cancers in China and all over the *** GCs are diagnosed at an advanced stage with unfavorable *** with some other countries,China has developed the government-funded national screening programs for GC and other major *** screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese *** screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous ***,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly *** studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further *** all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in *** the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of *** this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening.

关键词： Gastric cancer screening gastroendoscopy pepsinogen gastrin 17 Helicobacter pylori

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