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Determination of an Appropriate Endoscopic Monitoring Interval for Patients with gastric precancerous conditions in China

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Current Medical Science 2023年第2期43卷 268-273页

作者： Kai ZHAO Li-na FENG Su-hong XIA Wang-dong ZHOU Ming-yu ZHANG Yu ZHANG Ruo-nan DONG De-an TIAN Mei LIU Jia-zhi LIAO Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective gastric precancerous conditions such as atrophic gastritis(AG)and intestinal metaplasia(IM)are considered independent risk factors for gastric cancer(GC).The suitable endoscopic monitoring interval is unclear when we attempt to prevent GC *** study investigated the appropriate monitoring interval for AG/IM *** Totally,957 AG/IM patients who satisfied the criteria for evaluation between 2010 and 2020 were included in the *** and multivariate analyses were used to determine the risk factors for progression to high-grade intraepithelial neoplasia(HGIN)/GC in AG/IM patients,and to determine an appropriate endoscopic monitoring *** During follow-up,28 AG/IM patients developed gastric neoplasia lesions including gastric low-grade intraepithelial neoplasia(LGIN)(0.7%),HGIN(0.9%),and GC(1.3%).Multivariate analysis identified *** infection(P=0.022)and extensive AG/IM lesions(P=0.002)as risk factors for HGIN/GC progression(P=0.025).Conclusion In our study,HGIN/GC was present in 2.2%of AG/IM *** AG/IM patients with extensive lesions,a 1–2-year surveillance interval is recommended for early detection of HIGN/GC in AG/IM patients with extensive lesions.

关键词： atrophic gastritis endoscopic monitoring gastric cancer gastric precancerous conditions high-grade intraepithelial neoplasia intestinal metaplasia

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gastric epithelial histology and precancerous conditions

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 396-412页

作者： Hang Yang Wen-Juan Yang Bing Hu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

The most common histological type of gastric cancer(GC)is gastric adenocarcinoma arising from the gastric *** common variants include mesenchymal,lymphoproliferative and neuroendocrine *** Lauren scheme classifies GC into intestinal type,diffuse type and mixed *** WHO classification includes papillary,tubular,mucinous,poorly cohesive and mixed *** atrophic gastritis(CAG)and intestinal metaplasia are recommended as common precancerous *** definite precancerous condition of diffuse/poorly/undifferentiated type is *** superficial inflammation and hyperplasia of foveolar cells may be the ***,the management of early GC and precancerous conditions mainly relies on endoscopy including diagnosis,treatment and *** of precancerous conditions promotes the early detection and treatment of early GC,and even prevent the occurrence of *** the review,precancerous conditions including CAG,metaplasia,foveolar hyperplasia and gastric hyperplastic polyps derived from the gastric epithelium have been concluded,based on the overview of gastric epithelial histological organization and its renewal.

关键词： gastric cancer gastric precancerous conditions gastric epithelium Diagnosis Histopathology

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