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Effect of oxytocin on gastric ischemia-reperfusion injury in rats

Frontiers of Medicine 2007年第4期1卷 433-437页

作者： ZHANG Wenwen ZHANG Jianfu XU Ming ZHANG Yongmei Department of Physiology Xuzhou Medical CollegeXuzhou 221002China Department of Neurobiology Xuzhou Medical CollegeXuzhou 221002China Department of Pathophysiology Xuzhou Medical CollegeXuzhou 221002China

The effect of peripherally administered oxytocin(OT)on gastric ischemia-reperfusion injury(GI-RI)and its possible mechanism were *** Sprague-Dawley(SD)rats were randomly divided into different treatment groups(n=6).The animal GI-RI model was established by clamping the celiac artery for 30 min to induce ischemia and then released to allow reperfusion for 1 h,and the degree of GI-RI was assessed by scoring the gastric mucosal damage index(GMDI),the gastric fluid output,gastric fluid output,gastric acidity were measured and the surgical preparations of vagotomy and sympathectomy were used to investigate the possible mechanism of OT on *** results were as *** with the control group(NS plus GI-R only,GMDI 121.33P10.40,n=6),the intra peritoneal(ip)administration of oxytocin(20,100μg/0.5 mL)obviously attenuated GI-RI(Pgastric fluid output and the gastric acidity(evaluated by pH)of the control group were(430.17P87.36)μL,1.55P0.25(n=6),and those of the OT group were(102.45P48.00)μL,2.65P0.40(n=6)res pectively;differences had statistical significance(Pgastric mucosal against injury induced by ischemia-reperfusion,and the oxytocin receptor was *** effect of oxytocin may be mediated through the vagus and sympathetic nerve,and then lead to the reduction of gastric juice output and the depression of gastric acidity.

关键词： oxytocin ischemia reperfusion injury gastric mucosal damage index vagotomy sympathectomy

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