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gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 983-989页

作者： Zhang-yong LI Chao-shi REN Shu ZHAO Hong SHA Juan DENG College of Bioinformation Chongqing University of Posts and Telecommunications Chongqing 400065 China nstitute of Biomedical Engineering Chinese Academy of Medical Sciences ＆ Peking Union Medical College Tianjin 300192 China

For some time now,the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine,exocrine secretion,and gastric *** this paper,a noninvasive method to study gastric motility was developed,taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography(EGG).This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity(basic electric rhythm) and the mechanical gastric ***,preliminary clinical studies of healthy subjects and subjects with functional dyspepsia(FD) and gastritis were carried *** impedance gastric motility(IGM) measurements of the healthy and FD subjects were compared,along with the studies of the FD subjects before treatment and after one week and three weeks of *** also compared IGM measurements of healthy subjects and subjects with erosive gastritis,along with the studies of the subjects with erosive gastritis before treatment and after one week of *** show that FD subjects have poor gastric motility(Pgastric motility of FD subjects was not yet improved although the EGG had returned to normal by this *** three weeks of treatment,the regular IGM rhythm returned in FD *** was a significant difference of IGM parameters between the gastritis and healthy subjects(P0.05),These results suggest the possibility of clinic application of the proposed method.

关键词： gastric motility Electrical bioimpedance Electrogastrography Functional dyspepsia Gastritis

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Effect of exogenous hydrogen sulfide in the nucleus tractus solitarius on gastric motility in rats

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World Journal of Gastroenterology 2023年第29期29卷 4557-4570页

作者： Hong-Zhao Sun Chen-Yu Li Yuan Shi Jin-Jin Li Yi-Ya Wang Li-Na Han Lu-Jie Zhu Ya-Fei Zhang College of Life Science Qi Lu Normal UniversityZhangqiu 250200Shandong ProvinceChina

BACKGROUND Hydrogen sulfide(H2S)is a recently discovered gaseous neurotransmitter in the nervous and gastrointestinal *** exerts its effects through multiple signaling pathways,impacting various physiological *** nucleus tractus solitarius(NTS),a vital nucleus involved in visceral sensation,was investigated in this study to understand the role of H2S in regulating gastric function in *** To examine whether H2S affects the nuclear factor kappa-B(NF-κB)and transient receptor potential vanilloid 1 pathways and the neurokinin 1(NK1)receptor in the *** Immunohistochemical and fluorescent double-labeling techniques were employed to identify cystathionine beta-synthase(CBS)and c-Fos co-expressed positive neurons in the NTS during rat *** motility curves were recorded by inserting a pressure-sensing balloon into the pylorus through the stomach *** in gastric motility were observed before and after injecting different doses of NaHS(4 nmol and 8 nmol),physiological saline,Capsazepine(4 nmol)+NaHS(4 nmol),pyrrolidine dithiocarbamate(PDTC,4 nmol)+NaHS(4 nmol),and L703606(4 nmol)+NaHS(4 nmol).RESULTS We identified a significant increase in the co-expression of c-Fos and CBS positive neurons in the NTS after 1 h and 3 h of restraint water-immersion stress compared to the expressions observed in the control ***-NTS injection of NaHS at different doses significantly inhibited gastric motility in rats(P0.05).CONCLUSION NTS contains neurons co-expressing CBS and c-Fos,and the injection of NaHS into the NTS can suppress gastric motility in *** effect may be mediated by activating TRPV1 and NK1 receptors via the NF-κB channel.

关键词： Nucleus tractus solitarius Hydrogen sulfide gastric motility Nuclear factor kappa-B Transient receptor potential vanilloid 1

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EFFECTS OF ENTERAL AND PARENTERAL NUTRITION ON GASTROENTERIC HORMONES AND gastric motility AFTER SUBTOTAL GASTRECTOMY

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Chinese Medical Sciences Journal 2008年第2期23卷 113-116页

作者： Wei-ming Kang Jian-chun Yu Qun Zhang Mei-yun Ke Jia-ming Qian Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Gastroenterology Peking UnionMedical College Hospital Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100730

Objective To investigate the effects of enteral nutrition （EN） and parenteral nutrition （PN） on gastric motility and gastroentefic hormones after subtotal gastrectomy. Methods Forty-one patients underwent gastrectomy were randomly divided into EN group （n=20） and PN group （n=21 ）. From the first postoperative day to the seventh day, patients received either EN （EN group） or PN （PN group） with isocalofic （84.9kJ·kg^-1·d^-1） and isonitrogenous （0.11g·kg^-1·d^-1） intake. Serum gastrin （GAS）, plasma mofilin （MTL）, and plasma cholecystokinin （CCK） were measured on preoperative day, the first and seventh postoperative day. Electrogastrography （EGG） was measured on preoperative day and the seventh postoperative day. Results Compared with preoperafion, blood GAS, MTL, and CCK levels of 41 patients decreased significantly on the first day after subtotal gastrectomy （ P 〈 0. 001 ）, but returned to the preoperative levels one week later. EGG after gastrectomy showed that gastric basal electrical rhythm was significantly restrained （ P 〈 0. 001 ）. On the seventh day after subtotal gastrectomy, plasma MTL and CCK levels in EN group were higher than those in PN group （ P 〈 0.05 ）. There was no difference in GAS level between two groups. EGG in EN group was better than that in PN group postoper- atively. Conclusions The levels of gastroentefitic hormones and the gastric motility decrease significantly after subtotal gastrectomy. In contrast with PN, EN can accelerate the recovery of MTL, CCK, and gastric motility after subtotal gastrectomy.

关键词： enteral nutrition parenteral nutrition gastroenteric hormones gastric motility gastrectomy

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Effect of grouped ST36 or RN12 on gastric motility and sensation

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World Journal of Traditional Chinese Medicine 2017年第1期3卷 31-37页

作者： Guang Sun Hao Liu Kun Liu Hong-Feng Wang Mu-Jun Zhi Xin-Yan Gao Bing Zhu Institute of Acupuncture & Moxibustion China Academy of Chinese Medical Sciences Department of Acupuncture and Moxibustion Changchun University of Chinese Medicine The Third Hospital of Ulanchap Graduate School of Changchun University of Chinese Medicine

Objective: To investigate the effects of paired ST36 and RN12 acupuncture stimulation on gastric motility and the firing rate of responsible neurons in anesthetized ***: Using electrophysiological methods, we measured the effects of acupuncture at RN12, ST36, or RN12+ST36 on gastric motility as well as nerve discharges from the gastric sympathetic, vagal nerve, and wide dynamic range(WDR) neurons in the spinal dorsal horn T7-9 in anesthetized ***: 1) Acupuncture at RN12 inhibited gastric motility(83.84±4.49)% and vagal nerve discharge(65.64±5.67)%, but promoted sympathetic nerve activity(243.70±40.67)%; acupuncture at ST36 induced opposing effects on gastric motility(111.31±2.01)% and vagal nerve discharge(166.98±15.92)%. Interestingly, acupuncture at RN12+ST36 together yielded effects similar to that of acupuncture at RN12 alone(93.59±2.05)%,(54.52±7.12)%. 2) WDR neuron discharges induced by gastric distension were inhibited by acupuncture at RN12(194.56 ±18.79)%. However, acupuncture at ST36 induced a more significant inhibitory ***: Acupuncture at RN12 inhibits gastric motility by activation of the sympathetic reflex at the spinal level; acupuncture at ST36 promotes gastric motility by activation of the parasympathetic reflex at the supraspinal level, and acupuncture at RN12+ST36 produces a similar decrease in gastric motility as RN12 stimulation alone. Both acupoints decrease the effect of noxious gastric distention on WDR neuron activity, but paired RN12+ST36 stimulation does not significantly affect WDR neuron discharge.

关键词： ST36 RN12 Grouped acupoints gastric motility gastric sensation

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Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism

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World Journal of Gastroenterology 2012年第25期18卷 3282-3287页

作者： Shu Zhao Hong Sha Zhang-Yong Li, Chao-Shi Ren Institute of BiomedicalEngineering Chinese Academy of Medical Sciences and PekingUnion Medical College Tianjin 300192 China College of Bioinformation Chongqing Univer-sity of Posts and Telecommunications Chongqing 400065 China

AIM： To introduce a bioimpedance gastric motility mea- surement method based on an electrical-mechanical composite concept and a preliminary clinical application. METHODS： A noninvasive gastric motility measure- ment method combining electrogastrograrn （EGG） and impedance gastric motility （IGM） test was used. Prelim- inary clinical application studies of patients with func- tional dyspepsia （FD） and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients （mean age 40.9±9.7 years） and 40 healthy volun- teers （mean age 30.9±7.9 years） were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients （mean age 50.5±13.0 years） and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after ***： There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency （PNF） 70.8±25.5 in healthy subjects and 28.3 =t= 16.9 in FD patients, P 〈 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not im- proved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups （PNF 70.4：1：25.5 for healthy subjects and 36.1 4- 21.8 for gastritis patients, P 〈 0.05）. The EGG rhythm of the gastritis patients returned to normal （frequency insta- bility coefficient 2.22±0.43 before treatment and 1.77 ：t： 0.19 one wk after treatment, P 〈 0.05） after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tenden- cy toward improvement but had not reached statistical si

关键词： gastric motility Electrical bioimpedance Electrical-mechanical composite Electrogastrogram

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Effects of metoclopramide on gastric motility measured by short-term bio-impedance

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World Journal of Gastroenterology 2009年第38期15卷 4763-4769页

作者： María-Raquel Huerta-Franco Miguel Vargas-Luna Kathleen M Capaccione Etna Yaez-Roldán Ulises Hernández-Ledezma Ismael Morales-Mata Teodoro Córdova-Fraga Department of Applied Science and Labor Research DCS-Campus LeónUniversity of Guanajuato Department of Physical Engineering DCI-Campus LeónUniversity of Guanajuato Robert Wood Johnson Medical School The University of Medicine and Dentistry of New Jersey

AIM:To analyze the accuracy of short-term bio-impedance as a means of measuring gastric ***: We evaluated differences in the short-term electrical bio-impedance signal from the gastric region in the following conditions: (1) fasting state, (2) after the administration of metoclopramide (a drug that induces an increase in gastric motility) and (3) after food ingestion in 23 healthy volunteers. We record-ed the real component of the electrical impedance signal from the gastric region for 1000 s. We performed a Fast Fourier Transform (FFT) on this data and then compared the signal among the fasting, medicated, and postprandial conditions using the median of the area under the curve, the relative area under the curve and the main peak ***: The median of the area under the curve of the frequency range in the region between 2-8 cycles per minute (cpm) decreased from 4.7 cpm in the fasting condition to 4.0 cpm in the medicated state (t=3.32, P=0.004). This concurred with the decrease seen in the relative area under the FFT curve in the region from 4 to 8 cpm from 38.3% to 26.6% (t=2.81, P=0.012) and the increase in area in the region from 2 to 4 cpm from 22.4% to 27.7%, respectively (t=-2.5, P=0.022). Finally the main peak position also decreased in the region from 2 to 8 cpm. Main peak activity in the fasting state was 4.72 cpm and declined to 3.45 cpm in the medicated state (t=2.47, P=0.025). There was a decrease from the fasting state to the postprandial state at 3.02 cpm (t=4.0, P=0.0013). CONCLUSION: Short-term electrical bio-impedance can assess gastric motility changes in individuals experiencing gastric stress by analyzing the area medians and relative areas under the FFT curve.

关键词： Bio-impedance Fast Fourier Transform gastric motility Metoclopramide Postprandial

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Effects and mechanisms of L-glutamate microinjected into nucleus ambiguus on gastric motility in rats

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Chinese Medical Journal 2010年第8期123卷 1052-1057页

作者： SUN Hong-zhao ZHAO Shu-zhen CUI Xi-yun AI Hong-bin Key Laboratory of Animal Resistance College of Life Science Shandong Normal University Ji'nan Shandong 250014 China Department of Biological Science and Technology Shandong Institute of Education Ji'nan Shandong 250013 China

Background L-glutamate （L-GLU） is a major neurotransmitter in the nucleus ambiguus （NA）, which can modulate respiration, arterial pressure, heart rate, etc. This study investigated the effects and mechanisms of L-GLU microinjected into NA on gastric motility in rats. Methods A latex balloon connected with a pressure transducer was inserted into the pylorus through the forestomach for continuous recording of the gastric motility. The total amplitude, total duration, and motility index of gastric contraction waves within 5 minutes before microinjection and after microinjection were measured. Results L-GLU （5 nmol, 10 nmol and 20 nmol in 50 nl normal saline （PS） respectively） microinjected into the right NA significantly inhibited gastric motility, while microinjection of physiological saline at the same position and the same volume did not change the gastric motility. The inhibitory effect was blocked by D-2-amino-5-phophonovalerate （D-AP5, 5 nmol, in 50 nl PS）, the specific N-methyI-D-aspartic acid （NMDA） receptor antagonist, but was not influenced by 6-cyaon-7-nitroquinoxaline-2,3-（1H,4H）-dione （CNQX）（5 nmol, in 50 nl PS）, the non-NMDA ionotropic receptor antagonist. Bilateral subdiaphragmatic vagotomy abolished the inhibitory effect by microinjection of L-GLU into NA. Conclusions Microinjection of L-GLU into NA inhibits the gastric motility through specific NMDA receptor activity, not non-NMDA receptor activity, and the efferent pathway is the vagal nerves.

关键词： gastric motility L-glutamate nucleus ambiguus glutamate receptor vagotomy

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Role of vasoactive intestinal peptide and nitric oxide in the modulation of electroacupucture on gastric motility in stressed rats

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World Journal of Gastroenterology 2006年第38期12卷 6156-6160页

作者： Guo-Ming Shen Mei-Qi Zhou Guan-Sun Xu Ying Xu Gang Yin Institute of Integrated Traditional Chinese and Western Medicine Anhui TCM College Hefei 230038 Anhui Province China School of Acupuncture and Osteology Anhui TCM College Hefei 230038 Anhui Province China College of Basic Medicine Shanghai TCM University Shanghai 201203 China

AIM: To investigate the effects and mechanisms of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in the modulation of electroacupucture (EA) on gastric motility in restrained-cold stressed rats. METHODS: An animal model of gastric motility disorder was established by restrained-cold stress. gastric myoelectric activities were recorded by electrogastroent erography (EGG). VIP and NO concentrations in plasma and gastric mucosal and bulb tissues were detected by radioimmunoassay (RIA). VIP expression in the gastric walls was assayed using avidin-biotin-peroxidase complex (ABC) and image analysis. RESULTS: In cold restrained stressed rats, EGG was disordered and irregular. The frequency and amplitude of gastric motility were higher than that in control group (P gastric mucosal and bulb tissues were obviously decreased (P gastric motility were obviously lowered (P gastric mucosal and bulb tissues increased strikingly (P gastric motility. EA at “Zusanli” acupoint (ST36) can improve gastric motility of the stressed rats by increasing the levels of VIP and NO.

关键词： Vasoactive intestinal peptide Nitric oxide gastric motility Electroacupuncture

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Neural mechanism of acupuncture-modulated gastric motility

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World Journal of Gastroenterology 2007年第5期13卷 709-716页

作者： Yu-Qing Li Bing Zhu Pei-Jing Rong Hui Ben Yan-Hua Li Institute of Acupuncture-Moxibustion China Academy of Chinese Medical Sciences 16 Nanxiaojie of Dongzhimennei Beijing 100700 China Faculty of Acupuncture Hubei College of Traditional Chinese Medicine Wuhan 430061 Hubei Province China

AIM: To investigate the acupuncture-modulated gastric motility and its underlying neural ***: Intragastric pressure and/or waves of gastric contraction in rats were recorded by intrapyloric balloon and changes of gastric motility induced by acupuncture stimulation were compared with the background activity before any stimulation. Gastro-vagal or splanchnic-sympathetic nerves were recorded or cut respectively for investigating the involvement of autonomic nerve pathways. Spinalization experiment was also ***: Acupuncture-stimulation by exciting Aδ and/or C afferent fibers, could only modulate gastric motility. Acupuncture-stimulation on fore- and hind-limbs evoked a moderate gastric motility followed by increased vagus discharges with unchanged sympathetic activity, while the same stimulus to the acupoints in abdomen resulted in reversed effects on gastric motility and autonomic nervous activities. The inhibitory gastric response was completely abolished by splanchnic denervation, but the facilitative gastric response to stimulation of acupoints in limbs was not influenced, which was opposite to the effect when vagotomy was performed. The similar depressive effects were produced by the stimulation at the acupoints homo-segmental to the gastric innervation in the animals with or without spinalization. However, the facilitation induced by the stimulation at the acupoints hetero-segmental to the gastric innervation was not observed in the spinalized ***: Facilitative effects of stimulating hetero-segmental acupoints are involved in the intact preparation of vagal nerves and spinal cord, while the inhibitory response induced by stimulating homo-segmental acupoints is involved in the intact preparation of sympathetic nerves. Only the acupuncture-stimulation with intensity over the threshold of Aδ and/or C afferent fibers can markedly modulate gastrointestinal motility.

关键词： gastric motility Acupuncture-stimulation Intensity of acupuncture stimulation Aδ-fiber C-fiber Autonomic nervous system Supraspinal circuit

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Role of Enteric Glial Cells in gastric motility in Diabetic Rats at Different Stages

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第4期33卷 496-500页

作者：祁冉杨伟陈婕 Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Summary： Diabetes patients tend to have the gastrointestinal motility disorder. Although the relationship between the motility disorder and both the neurons and Cajal cells in the enteric nervous system （ENS） is well established, little is known about the role of enteric glial cells （EGCs） in gastric motility in diabetes. This study aimed to examine the expression of the glial marker S100B and morphology of EGCs in gastric tissues and the relationship between activated EGCs and the damage of gastric emptying in diabetic models. The diabetic model of rat was induced with 1% streptozotocin （STZ）. The model rats at 7-14 days and at 56-63 days were defined as early diabetic rats and advanced diabetic rats, re- spectively, and normal rats at the two time periods served as their corresponding controls. The gastric emptying rate of the rats was tested by using the phenol red solution. The ultrastructure of EGCs in the gastric antrum was observed by the transmission electron microscopy, and the expression of S100B in the myenteric plexus was immunohistochemically detected. The results showed that the gastric emptying rate was significantly increased in the early diabetic rats and decreased in the advanced diabetic rats when compared with their corresponding control rats （P〈0.01 for both）. The ultrastructure of EGCs was mostly normal in both the early diabetic and control groups. Vacuolization of mitochondria and expan- sion of endoplasmic reticulum occurred in both the advanced diabetic group and its control group, and even the structure of smooth muscle cells and intestinal neurons was destroyed in the advanced diabetic group. The expression level of S100B in the advanced diabetic group was significantly decreased com- pared with its control group （P〈0.05）. It was obviously increased in the early diabetic control group when compared with the advanced diabetic control group （P〈0.05）. However, there was no significant difference in the S 100B expression between the early dia

关键词： gastric motility enteric glial cells SIOOB diabetes

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