检索结果-南通市图书馆

New selenoproteins identified in silico from the genome of Anopheles gambiae

Science China(Life Sciences) 2007年第2期50卷 251-257页

作者： JIANG Liang1,2,LIU Qiong1,CHEN Ping3,GAO ZhongHong3 & XU HuiBi3 1 College of Life Science,Shenzhen University,Shenzhen 518060,China 2 Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China 3 Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074,China College of Life Science Shenzhen University Shenzhen China Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun China Department of Chemistry Huazhong University of Science and Technology Wuhan China

Selenoprotein is biosynthesized by the incorporation of selenocysteine into proteins,where the TGA codon in the open reading frame does not act as a stop signal but is translated into *** dual functions of TGA result in mis-annotation or lack of selenoproteins in the sequenced genomes of many *** computational tools fail to correctly predict ***,we devel-oped a new method to identify selenoproteins from the genome of Anopheles gambiae *** on released genomic information,several programs were edited with PERL language to identify selenocysteine insertion sequence(SECIS)element,the coding potential of TGA codons,and cys-teine-containing homologs of selenoprotein *** results showed that 11365 genes were termi-nated with TGA codons,918 of which contained SECIS *** search revealed that 58 genes contained Sec/Cys pairs and similar flanking regions around in-frame TGA ***,7 genes were found to fully meet requirements for selenoproteins,although they have not been anno-tated as selenoproteins in NCBI *** from their basic properties,the newly found se-lenoproteins in the genome of Anopheles gambiae are possibly related to in vivo oxidation tolerance and protein regulation in order to interfere with anopheles' vectorial capacity of *** study may also provide theoretical bases for the prevention of malaria from anopheles transmission.

关键词： selenoprotein selenocysteine Anopheles gambiae genome bioinformatics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fine-scale evolutionary genetic insights into Anopheles gambiae X-chromosome

引用

Journal of Biomedical Science and Engineering 2009年第5期2卷 304-311页

作者： Hemlata Srivastava Jyotsana Dixit Aditya P. Dash Aparup Das Evolutionary Genomics and Bioinformatics Laboratory National Institute of Malaria Research Sector 8 Dwarka New Delhi-110 077 India Present address: World Health Organization Southeast Asian Regional Office New Delhi India

Understanding the genetic architecture of indi-vidual taxa of medical importance is the first step for designing disease preventive strategies. To understand the genetic details and evolu-tionary perspective of the model malaria vector, Anopheles gambiae and to use the information in other species of local importance, we scanned the published X-chromosome se-quence for detail characterization and obtain evolutionary status of different genes. The te-locentric X-chromosome contains 106 genes of known functions and 982 novel genes. Majori-ties of both the known and novel genes are with introns. The known genes are strictly biased towards less number of introns;about half of the total known genes have only one or two in-trons. The extreme sized (either long or short) genes were found to be most prevalent (58% short and 23% large). Statistically significant positive correlations between gene length and intron length as well as with intron number and intron length were obtained signifying the role of introns in contributing to the overall size of the known genes of X-chromosome in An. gam-biae. We compared each individual gene of An. gambiae with 33 other taxa having whole ge-nome sequence information. In general, the mosquito Aedes aegypti was found to be ge-netically closest and the yeast Saccharomyces cerevisiae as most distant taxa to An. gambiae. Further, only about a quarter of the known genes of X-chromosome were unique to An. gambiae and majorities have orthologs in dif-ferent taxa. A phylogenetic tree was constructed based on a single gene found to be highly orthologous across all the 34 taxa. Evolutionary relationships among 13 different taxa were in-ferred which corroborate the previous and pre-sent findings on genetic relationships across various taxa.

关键词： Anopheles gambiae Comparative Genomics Evolution Malaria Orthologous Genes X-chromosome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biogenic Synthesis of Silver Nanoparticles Using Guava (Psidium guajava) Leaf Extract and Its Larvicidal Action against Anopheles gambiae

引用

Journal of Biomaterials and Nanobiotechnology 2020年第1期11卷 49-66页

作者： Agnes Antoinette Ntoumba Francois Eya’ane Meva Wolfgang Eyisap Ekoko Loick Pradel Kojom Foko Etoile Ngo Hondt Carsten Schlüsener Bastian Moll Gisele Etame Loe Philippe Belle Ebanda Kedi Jean Yves Sikapi Fouda Christoph Janiak Leopold Gustave Lehman Department of Animal Biology and Physiology Faculty of Science The University of Douala Douala Cameroon Department of Pharmaceutical Sciences Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Institute for Inorganic Chemistry and Structural Chemistry Heinrich-Heine-University Düsseldorf Universitätsstr 1 Düsseldorf Germany Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC) Yaoundé Cameroon

The progress in the field of nanotechnology has contributed to the development of tools for combating the most critical problems in developing countries. The requirements that such tools should meet are low-cost and resource settings, environmental protection, ease of use, and availability. The use of plant properties for the generation of nanoparticles (NPs), which serve as bioinsecticides to combat the plasticity and resistance of mosquitoes and parasites, is considered possible. Here, we report for the first time the larvicidal activity of silver (Ag) NPs (AgNPs) synthesized from Psidium guajava (P. guajava) extract, which targets the 4th instar larvae of Anopheles gambiae. Concentrations of AgNPs between 0 and 200 ppm were used and their LC50 at 24 h and 48 h were determined as 19.55 ppm and 8.737 ppm, respectively. The AgNPs were stable and highly effective against the larvae of A. gambiae and thereby we anticipate that they can be used to combat vector-borne diseases in developing countries.

关键词： Vector Control Anopheles gambiae Silver Nanoparticles Psidium guajava

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of Urban Agriculture on the Species Distribution and Insecticide Resistance Profile of Anopheles gambiae s.s.and Anopheles coluzziiin Accra Metropolis, Ghana

引用

Advances in Entomology 2018年第3期6卷 198-211页

作者： Joseph Chabi Miracle C.Eziefule Rebecca Pwalia Joannitta Joannides Dorothy Obuobi Godwin Amlalo Charlotte A.Addae Iddrisu Alidu Dominic Acquah-Baidoo Samuel Akporh Sampson Gbagba Kwadwo K.Frempong Melinda P.Hadi Helen Pates Jamet Samuel K.Dadzie Vestergaard-NMIMR Vector Labs Parasitology DepartmentNoguchi Memorial Institute for Medical Research(NMIMR)University of GhanaAccraGhana Parasitology Department Noguchi Memorial Institute for Medical Research(NMIMR)University of GhanaAccraGhana African Regional Postgraduate Programme in Insect Sciences(ARPPIS) University of GhanaAccraGhana Vestergaard East Africa NairobiKenya Vestergaard Washington DCUSA

Malaria incidence in urban areas has generally been low compared to rural areas but recent data indicate that urban malaria remains a public health problem. It is therefore important to understand the factors that promote urban malaria to help formulate future vector control strategies. This study compared Anopheles gambiae s.l. (A. gambiae s.l.) species composition, distribution and insecticide resistance mechanisms between vegetable and non-vegetable growing areas in Accra Metropolis. Four sites were selected within the city of Accra which comprised of two vegetable-growing and two non-vegetable growing areas. WHO susceptibility tests were carried out on adults A. gambiae s.l. reared from larvae collected from the sites. Five insecticides were tested and the A. gambiae complex, resistance genotypes and enzyme activities of each population were characterized. All A. gambiae s.l. populations tested were resistant to all the insecticides, but relatively lower mortalities were observed in the vegetable growing areas. The mortality against 0.05% deltamethrin was 2.6% (Opeibea) and 12.5% (Korle-Bu) for the vegetable growing areas and 36.2% (Achimota) and 38.9% (Mataheko) in the non-vegetable growing areas. Anopheles gambiae s.s. (95% of Opeibea population) and Anopheles coluzzii, (98% of Korle-Bu population) were the dominant species in the vegetable growing areas. The voltage-gated sodium channel (Vgsc-1014F) frequencies of all the populations were similar but the acetylcholinesterase (ace-1) frequencies were significantly lower (p A. gambiae s.l. from Opeibea than from the other areas. The contribution of urban agriculture in the development of insecticide resistance needs to be considered in the formulation of future vector control strategies alongside other domestic usages.

关键词： Anopheles gambiae s.s. Anopheles coluzzii Insecticide Resistance Malaria Piperonyl Butoxide (PBO) Urban Agriculture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study

引用

Journal of Biophysical Chemistry 2011年第2期2卷 135-136页

作者： William N. Setzer Department of Chemistry University of Alabama in Huntsville Huntsville AL 35899 USA

The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione s... 详细信息

关键词： Malaria DDT Anopheles gambiae Glutathione S-transferase Docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modelling of the Abundance of Malaria Mosquitoes Using Poisson Mixed Model

引用

Journal of Applied Mathematics and Physics 2019年第10期7卷 2492-2507页

作者： Edwin Moyo Chipego Munachoonga Dennis Lubumbe Alick Banda Antony Ngunyi Stanley Jere Department of Mathematics and Statistics Northrise University Ndola Zambia Department of Business and Social Sciences Chreso University Lusaka Zambia Department of Research Northrise University Ndola Zambia Department of Mathematics and Statistics University of Zambia Lusaka Zambia Department of Mathematics and Statistics Dedan Kimathi University of Science and Technology Nyeri Kenya Department of Mathematics and Statistics Mulungushi University Kabwe Zambia

Anopheles funestus and Anopheles gambiae are malaria vector mosquitoes. Knowing their resting behavior is important for implementing control methods. The aim of this study was to investigate the resting behaviour of the two malaria mosquitoes. The study was conducted in Kilombero River Valley and mosquitoes were collected using indoor and outdoor traps from 2012-2015. Poisson mixed models were used to quantify the impact of environment variables on resting behaviour. A log ratio rate between the type of trap and its interaction with environmental variables was used to determine if there was a change over time in the resting behaviour. A total of 4696 mosquitoes were resting indoors of which 57% were A. funestus and 43% were A. gambiae. Similarly, a total of 12,028 mosquitoes were resting outdoor of which 13% were A. funestus and 87% were A. gambiae. Temperature was significant and affected the resting behaviour of A. funestus. Humidity, saturation deficit and temperature were significant variables influencing the resting behaviour of A. gambiae. A. funestus was resting indoor while A. gambiae was resting outdoor over time generally. The findings of this study on the effects of environmental variables and the variations in the resting behaviour of A. gambiae and A. funestus could be used as a guide to implementing appropriate intervention measures such as indoor residential spraying (IRS), insecticide treated nets (ITNs) and mosquito repellents.

关键词： A. gambiae A. funestus Resting Behaviour Mosquito Density Environmental Variables

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：