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Mirror-like tongue is an important predictor of acute heart failure:a cohort study of acute heart failure in Chinese patients

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1243-1251页

作者： CHEN Yunhu YIN Moqing FAN Lihua JIANG Xuechun ZHANG Tao ZHU Xingyu XU Hongfeng Department of Cardiology Taicang TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou 215400China Department of Cardiology Changzhou Hospital affiliated with Nanjing University of Chinese MedicineChangzhou 213003China Department of Clinical Pharmacy Taicang TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou 215400China

OBJECTIVE:To reveal that mirror-like tongue,observed via a noninvasive inspection,is a powerful indicator of the severity and prognosis of patients with acute heart failure(AHF).METHODS:This was an observational,prospective study.A total of 408 patients who met the inclusion criteria and were diagnosed with AHF for the first time at Taicang Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine from August 2019 to January 2021 were selected as the research subjects.According to their tongue fur,the patients were divided into group A(mirror-like tongue group)and group B(non-mirror-like tongue group).The clinical characteristics and incidence of major adverse cardiovascular events(MACEs)within 1 year of follow-up were systematically compared between the two groups.RESULTS:Sixty-five patients were included in group A,and 343 patients were included in group B.There were 32 males and 33 females in group A and 168 males and 175 females in group B.The average age of the overall population was 64 years old,and the average age of group A was significantly higher than that of group B(74 vs 62 years,P<0.001).Compared with that in group B,the left ventricular ejection fraction(LVEF)in group A was significantly lower(35%vs 42%,P<0.001),and the log N-terminal pro B-type natriuretic peptide(NT-proBNP)level was significantly higher(4.0 vs 3.4,P<0.001).The proportion of the combined application of vasoactive drugs in group A was significantly higher than that in group B(64%vs 38%,P<0.001).Group B had a higher proportion of coronary angiography(29.5%vs 16.9%,P=0.038).Group A was more inclined to require mechanical ventilation than group B(33.9%vs 22.5%,P=0.049).The length of hospital stay in group A was significantly longer than that in group B(13.1 vs 7.6,P<0.001).The incidence of MACEs,such as recurrence of AHF,new myocardial infarction and stroke,in group A within one year was higher than that in group B(P=0.007,0.009,<0.001).The incidence of cumulative MACEs in group A was significantly high

关键词： heart failure risk factors fur Yin deficiency cohort studies

Protein Containing the GGDEF Domain Affects Motility and Biofilm Formation in Vibrio cholerae and is Negatively Regulated by fur and HapR

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Biomedical and Environmental Sciences 2023年第10期36卷 949-958页

作者： GAO He MA Li Zhi QIN Qin CUI Yao MA Xiao Han ZHANG Yi Quan KAN Biao State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Medical Risk Management Section Third Medical CentreChinese PLA(People’s Liberation Army)General HospitalBeijing 100039China Department of Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong Third People's HospitalNantong 226006JiangsuChina 3.Department of Clinical LaboratoryAffiliated Nantong Hospital 3 of Nantong UniversityNantong Third People's Hospital

Objective This study aimed to investigate whether the VCA0560 gene acts as an active diguanylate cyclase(DGC)in Vibrio cholerae and how its transcription is regulated by fur and Hap R.Methods The roles of VCA0560 was investigated by utilizing various phenotypic assays,including colony morphological characterization,crystal violet staining,Cyclic di-GMP(c-di-GMP)quantification,and swimming motility assay.The regulation of the VCA0560 gene by fur and Hap R was analyzed by luminescence assay,electrophoretic mobility shift assay,and DNase I footprinting.Results VCA0560 gene mutation did not affect biofilm formation,motility,and c-di-GMP synthesis in V.cholerae,and its overexpression remarkably enhanced biofilm formation and intracellular c-di-GMP level but reduced motility capacity.The transcription of the VCA0560 gene was directly repressed by fur and the master quorum sensing regulator Hap R.Conclusion Overexpressed VCA0560 functions as an active DGC in V.cholerae,and its transcription is repressed by fur and Hap R.

关键词： Vibrio cholera Cyclic di-GMP VCA0560 fur HapR

Yangqing Chenfei formula(养清尘肺方)alleviates crystalline silica induced pulmonary inflammation and fibrosis by suppressing macrophage polarization

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1126-1139页

作者： TIAN Xinrong HOU Runsu LIU Xinguang ZHAO Peng TIAN Yange LI Jiansheng Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases co constructed by Henan province and Education Ministry of P.R.China Zhengzhou 450046China Academy of Chinese Medical Sciences Henan University of Chinese MedicineZhengzhou 450046China Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China

OBJECTIVE:To explore the underlying mechanisms of the effects of Yangqing Chenfei formula(养清尘肺方,YCF) on inflammation and fibrosis in silicosis via inhibition of macrophage polarization.METHODS:A silicotic rat model was established via a single intratracheal instillation of silica particles on the first day of week 0.Subsequently,YCF was administered intragastrically to silicotic rats during weeks 0-2 and 5-8 twice daily.The mouse-derived alveolar macrophage cell line was used to investigate the mechanisms of YCF in M1/M2 polarization.RESULTS:YCF treatment effectively inhibited lung pathological changes,including inflammatory cell infiltration and tissue damage,and increased the forced expiratory volume in the first 0.3 s,functional residual capacity,and maximal mid-expiratory flow in weeks 2 and 8.furthermore,the treatment improved lung functions by upregulating tidal volume,pause increase,and expiratory flow at 50% tidal volume from weeks 5 to 8.Moreover,YCF could significantly suppressed the progression of inflammation and fibrosis,by reducing the levels of inflammatory cytokines,as well as collagen-Ⅰ and Ⅲ.YCF treatment also decreased the numbers of macrophages and M1/M2 macrophages and the level of transforming growth factor-β(TGF-β).Additionally,YCF5,the effective substance in YCF,decreased lipopolysaccharide and interferon-γ-induced M1 macrophage polarization in a concentration-dependent manner.The mechanism of anti-M1 polarization might be related to a decrease in extracellular signal-regulated kinase,c-JUN N-terminal kinase,P38,and P65 phosphorylation.furthermore,YCF5 inhibited interleukin-4-induced M2 macrophages by decreasing the protein and m RNA expressions of arginase-1 and CD206 as well as the levels of profibrotic factors,such as TGF-β and connective tissue growth factor.The mechanisms underlying the anti-M2 polarization of YCF5 were primarily associated with the inhibition of the nuclear translocation of phosphorylated signal transducer and activator of transcription 6(pSTAT6).CONCLUSION:YCF signi

关键词： heart failure risk factors fur Yin deficiency cohort studies

Reciprocal Regulation between fur and Two RyhB Homologs in Yersinia pestis,and Roles of RyhBs in Biofilm Formation

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Biomedical and Environmental Sciences 2021年第4期34卷 299-308页

作者： NI Bin WU Hai Sheng XIN You Quan ZHANG Qing Wen ZHANG Yi Quan School of Medicine Jiangsu UniversityZhenjiang 212013JiangsuChina Qinghai Institute for Endemic Disease Prevention and Control Xining 811602QinghaiChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122JiangsuChina

Objective To investigate reciprocal regulation between fur and two RyhB homologs in Yersinia pestis(Y.pestis),as well as the roles of RyhBs in biofilm formation.Methods Regulatory relationships were assessed by a combination of colony morphology assay,primer extension,electrophoretic mobility shift assay and DNase I footprinting.Results fur bound to the promoter-proximal DNA regions of ryhB1 and ryhB2 to repress their transcription,while both RyhB1 and RyhB2 repressed the expression of fur at the post-transcriptional level.In addition,both RyhB1 and RyhB2 positively regulated Y.pestis biofilm exopolysaccharide(EPS)production and the expression of hmsHFRS and hmsT.Conclusion fur and the two RyhB homologs exert negative reciprocal regulation,and RyhB homologs have a positive regulatory effect on biofilm formation in Y.pestis.

关键词： Yersinia pestis RyhB fur Biofilm

A fur-regulated type Ⅵ secretion system contributes to oxidative stress resistance and virulence in Yersinia pseudotuberculosis

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Stress Biology 2023年第1期3卷 20-34页

作者： Yuxin Zuo Changfu Li Danyang Yu Kenan Wang Yuqi Liu Zhiyan Wei Yantao Yang Yao Wang Xihui Shen Lingfang Zhu State Key Laboratory of Crop Stress Biology for Arid Areas Shaanxi Key Laboratory of Agricultural and Environmental MicrobiologyCollege of Life SciencesNorthwest A&F UniversityYangling 712100ShaanxiChina

The type Ⅵ secretion system(T6SS)is a widespread protein secretion apparatus deployed by many Gram-negative bacterial species to interact with competitor bacteria,host organisms,and the environment.Yersinia pseudotuber-culosis T6SS4 was recently reported to be involved in manganese acquisition;however,the underlying regulatory mechanism still remains unclear.In this study,we discovered that T6SS4 is regulated by ferric uptake regulator(fur)in response to manganese ions(Mn^(2+)),and this negative regulation of fur was proceeded by specifically recogniz-ing the promoter region of T6SS4 in Y.pseudotuberculosis.furthermore,T6SS4 is induced by low Mn^(2+)and oxidative stress conditions via fur,acting as a Mn^(2+)-responsive transcriptional regulator to maintain intracellular manganese homeostasis,which plays important role in the transport of Mn^(2+)for survival under oxidative stress.Our results pro-vide evidence that T6SS4 can enhance the oxidative stress resistance and virulence for Y.pseudotuberculosis.This study provides new insights into the regulation of T6SS4 via the Mn^(2+)-dependent transcriptional regulator fur,and expands our knowledge of the regulatory mechanisms and functions of T6SS from Y.pseudotuberculosis.

关键词： Type Ⅵ secretion system fur Manganese Oxidative stress Virulence

肺炎克雷伯菌铁摄取调节蛋白(fur)的生物学功能及对fyuA的转录调控

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云南大学学报（自然科学版） 2022年第1期44卷 195-202页

作者：杜玲张加雪袁灵月谌丽妃李迎丽邱景富重庆医科大学公共卫生与管理学院重庆400016

铁摄取调节蛋白(ferric uptake regulator,fur)是细菌重要的调控因子,研究旨在探究肺炎克雷伯菌fur对铁摄入及生物膜形成的影响,分析fur对可能的靶基因fyuA(耶尔森菌素的受体)的调控作用.首先,采用同源重组技术构建突变株Δfur及回补株C... 详细信息

铁摄取调节蛋白(ferric uptake regulator,fur)是细菌重要的调控因子,研究旨在探究肺炎克雷伯菌fur对铁摄入及生物膜形成的影响,分析fur对可能的靶基因fyuA(耶尔森菌素的受体)的调控作用.首先,采用同源重组技术构建突变株Δfur及回补株C-Δfur.然后,采用生长曲线、CAS检测和结晶紫染色对野生株、突变株及回补株的铁摄入及生物膜形成表型进行测定.最后,通过RT-qPCR及GFP报告基因融合实验明确fur对fyuA的调控.结果显示,成功构建突变株及回补株;生长曲线分析表明fur基因影响细菌生长速度;fur的缺失使铁载体的生成量增加,生物膜的形成减少;铁充足条件下,fur负调控fyuA基因的表达.研究通过构建fur基因敲除株,初步分析了肺炎克雷伯菌铁摄取调节蛋白fur的功能,明确了fur对fyuA的转录调控机制.

关键词：肺炎克雷伯菌转录调控 fur fyuA

A clinical report of entangled neonates' umbilical cord with queen's fur in Persian cat

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Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 502-504页

作者： O Azari B Akhtardanesh Department of Clinical Sciences Faculty of Veterinary MedicineShahid Bahonar University

A 3-year-old Persian queen was referred to Teaching Veterinary Hospital while 3 neonates' umbilical cords were entangled with the queen's tail hair.Close inspection of the cat showed that the umbilical cords of 3 kittens had twisted around together and entangled with the moms' hairs in the base of tail region.Also this complex has been warped around the left tarsus of one of the involved kittens and caused swelling and skin darkness in the involved limb.Operation was carried out urgently.After cutting the queen's involved hairs the kittens were released.Then the twisted umbilical cords and the hairs were isolated from the umbilical cord and the involved leg was released from the umbilical cords and the twisted umbilical cords were separated from each other.During one week follow up,dry gangrene occurred in the distal extremity of the injured limb and consequently,amputation was performed on the distal part of tibia.Our clinical findings suggest that long hair coats of queens could be a maternal life threatening factor for neonates' life.

关键词： Persian cat Neonate Umbilical cord Queen’s fur

CALCULATION OF NATURAL FREQUENCIES FOR THE PLANAR SIX-BAR LINKAGE OF WATT TYPE

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Journal of China Textile University(English Edition) 1991年第3期9卷 49-57页

作者：张代昌刘小豹 Department of Mechanical Engineering Department of Mechanicel Engineering

By using transfer matrix,the lower-order natural frequencies of the Watt type planar six-barlinkage are calculated in this paper.The experiment of the modal analysis is done with the SignalProcessor 7T17S,and the experiment results agree with the calculated ones.This method only re-quires calculation of lower-order transfer matrix and determinant values,so that, it can be done ona minicomputer such as IBM/PC.The method adopted in this paper is also suitable for vibrationanalysis of other types of linkages.

关键词： vibration analysis transfer matrix modal analysis fur sewing machine bend needle mechanism planar linkage six-bar linkage of Watt type

Pneumonic Plagues,Environmental Changes,and the International fur Trade:The Retreat of Tarbagan Marmots from Northwest Manchuria,1900s-30s

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Frontiers of History in China 2019年第3期14卷 291-322页

作者： Yubin Shen Institute for the History of Science 14195 BerlinGermany

Inspired by recent environmental historical studies on animal extinctions and human-animal relations,this paper shifts scholarly attention from the plague-centered narrative of the great Pneumonic Plague Epidemics(1910—11)to the fate of the plague host animals,Tarbagan marmots(Marmota sibirica>,and examines their ncar-extinction in Northwest Manchuria(Hulunbuir)from the 1900s to 1930s.Focusing on changing images of Tarbagan marmots from“inexpensive,”“sacred,”and“beneficial”in the pre-modem period to“valuable,”“dangerous,”and“noxious”in the early twentieth century,it argues that three interrelated factors:the international fur trade,pneumonic plagues,and environment changes together resulted in the“retreat of the marmots.”It also]uses this case study to help us better understand larger historical changes that occurred by contextualizing them in terms of human-marmot relations in Manchuria,China and beyond.

关键词： Manchuria marmots plagues fur trade environmental changes