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Can fundus fluorescein angiography be Performed for Diabetic Patients on Oral Metformin

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Chinese Medical Sciences Journal 2017年第2期32卷 119-122页

作者： JunhuiDu Rong Li Department of Ophthalmology Xi'an Ninth Hospital Medical College of Xi'an Jiaotong University Xi'an Shanxi 710054 China Department of Ophthalmology The First Affiliated Hospital of Xi'an Medical University Xi'an Shanxi 710077 China

Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before fundus fluorescein angiography （FFA） remains largely unclear. Some endocrinologists suggest stop metformin before FFA. However, ophthalmologists do not always adopt this opinion in their practice. This situation may lead to disputes between physicians and patients. This article analyzed contrast-induced nephropathy（CIN） and the related contrast agent, as well as the adverse reactions of fluorescein angiography. It pointed out that the discrepancy may be caused by misunderstanding of contrast agents used in FFA. For angiography using iodine contrast agent, metformin must be stopped because of the increased possibility of CIN, while for FFA using fluorescein sodium, no CIN has been reported yet. Therefore, the authors believe FFA is safe for diabetic patients with oral metformin and it is unnecessary to stop metformin before the examination.

关键词： fundus fluorescein angiography diabetes mellitus metformin contrast-induced nephropathy

Application of non-mydriatic fundus photography-assisted telemedicine in diabetic retinopathy screening

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World Journal of Diabetes 2024年第2期15卷 251-259页

作者： Wan Zhou Xiao-Jing Yuan Jie Li Wei Wang Hao-Qiang Zhang Yuan-Yuan Hu Shan-Dong Ye Department of Endocrinology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Anhui Provincial HospitalAffiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Early screening and accurate staging of diabetic retinopathy(DR)can reduce blindness risk in type 2 diabetes ***’s complex pathogenesis involves many factors,making ophthalmologist screening alone insufficient for prevention and ***,endocrinologists are the first to see diabetic patients and thus should screen for retinopathy for early *** To explore the efficacy of non-mydriatic fundus photography(NMFP)-enhanced telemedicine in assessing DR and its various *** This retrospective study incorporated findings from an analysis of 93 diabetic patients,examining both NMFP-assisted telemedicine and fundus fluorescein angiography(FFA).It focused on assessing the concordance in DR detection between these two ***,receiver operating characteristic(ROC)curves were generated to determine the optimal sensitivity and specificity of NMFP-assisted telemedicine,using FFA outcomes as the standard *** In the context of DR diagnosis and staging,the kappa coefficients for NMFPassisted telemedicine and FFA were recorded at 0.775 and 0.689 respectively,indicating substantial intermethod ***,the NMFP-assisted telemedicine’s predictive accuracy for positive FFA outcomes,as denoted by the area under the ROC curve,was remarkably high at 0.955,within a confidence interval of 0.914 to 0.995 and a statistically significant P-value of less than *** predictive model exhibited a specificity of 100%,a sensitivity of 90.9%,and a Youden index of *** NMFP-assisted telemedicine represents a pragmatic,objective,and precise modality for fundus examination,particularly applicable in the context of endocrinology inpatient care and primary healthcare settings for diabetic *** implementation in these scenarios is of paramount significance,enhancing the clinical accuracy in the diagnosis and therapeutic management of *** methodology not only streamlines patient evaluation

关键词： Diabetes Diabetic retinopathy Non-mydriatic fundus photography-assisted telemedicine fundus fluorescein angiography

Protective effects of umbilical cord mesenchymal stem cell exosomes in a diabetic rat model through live retinal imaging

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1828-1833页

作者： Yan Fu Xiang Gao Guang-Hui He Song Chen Zhao-Hui Gu Yue-Ling Zhang Li-Ying Li College of Medicine Nankai UniversityTianjin 300071China Department of Ophthalmology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina Tianjin Eye Hospital Tianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Ophthalmic Center of Xinjiang Production and Construction Corps Hospital Urumqi 830002Xinjiang Uygur Autonomous RegionChina

AIM:To assess the protective effect of human umbilical cord mesenchymal stem cell exosomes(hucMSC-Exs)in a diabetic rat model by using a variety of retinal ***:hucMSCs were subjected to differential ultracentrifugation for the collection of exosomes,and transmission electron microscopy(TEM),nanoparticle tracking analysis(NTA)using a NanoSight analysis system and Western blotting(WB)were used to analyze the expression of surface marker proteins such as CD63,CD9 and ***(STZ)was injected into the intraperitoneal cavity to establish a diabetic *** were divided into a normal group,diabetic group and hucMSC-Ex *** fluorescein angiography(FFA),optical coherence tomography(OCT)and other live imaging methods were used to observe the fundus of the ***,the eyeballs of rats from each group were collected for hematoxylin-eosin(HE)staining to further analyze the retinal ***:Through TEM,NTA and WB,we successfully isolated *** FFA and OCT confirmed that hucMSC-Exs effectively prevented early retinal vascular damage and thickening of the ***,HE staining of rat retinal sections revealed that exosomes effectively alleviated retinal structure disruption caused by ***:hucMSC-Exs have a protective effect on the retina in diabetic rat through FFA,OCT and HE staining.

关键词： human umbilical cord mesenchymal stem cells exosomes diabetic retinopathy fundus fluorescein angiography optical coherence tomography rat

Multimodal imaging study of lipemia retinalis with diabetic retinopathy:A case report

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World Journal of Clinical Cases 2022年第19期10卷 6736-6743页

作者： Sheng-Juan Zhang Zhong-Yang Yan Li-Fei Yuan Yan-Hui Wang Li-Fei Wang Department of Ophthalmology Hebei Provincial Eye HospitalHebei Provincial Key Laboratory of OphthalmologyHebei Provincial Eye InstituteXingtai 054001Hebei ProvinceChina

BACKGROUND Lipemia retinalis(LR)is a rare disease related to ***,the symptoms of hypertriglyceridemia are insidious and difficult to detect without blood *** fundus is the only site where blood vessels can be observed *** the specific performance of LR in multimodal imaging fundus examinations can help diagnose more patients with abnormal *** SUMMARY A 29-year-old woman with type 2 diabetes presented to our clinic complaining of a six-day loss of visual acuity in the left *** fundus color images showed typical LR:Arteries and veins were the same pink-white *** images showed hyperinfrared reflections of the arteries and *** coherence tomography(OCT)showed numerous high point-like reflections in the retinal section,corresponding to different calibers of blood vessel *** reflections were seen in the big vessels of the *** fluorescein angiography(FFA)and optical coherence tomography angiography(OCTA)showed no significant *** examination found a total cholesterol level of 13.98 mmol/L,triglyceride 20.55 mmol/L,which confirmed the diagnosis of *** treatment to lower blood lipids and control blood glucose,the fundus imaging showed that the blood lipids in the patient had returned to *** LR shows specific changes in fundus color photography,infrared photography,and *** and OCTA were not sensitive to LR changes.

关键词： Lipemia retinalis fundus color photography Infrared photography Optical coherence tomography fundus fluorescein angiography Case report

Clinical features of retinal amyloid angiopathy with transthyretin Gly83Arg variant

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 128-134页

作者： Gang Su Xing-Wang Chen Jun-Lin Pan Hong Li Bing Xie Shan-Jun Cai Department of Ophthalmology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Guizhou Eye Hospital Zunyi 563000Guizhou ProvinceChina Guizhou Provincial Branch of National Eye Disease Clinical Research Center Zunyi 563000Guizhou ProvinceChina Special Key Laboratory of Ocular Diseases of Guizhou Province Zunyi 563000Guizhou ProvinceChina

AIM:To report on the clinical features of patients with retinal amyloid angiopathy(RAA)who were identified to be caused by the transthyretin(TTR)Gly83Arg ***:Case series of five patients diagnosed with RAA was collected at Affiliated Hospital of Zunyi Medical University from January 2010 to December *** clinical features,therapeutic strategies,and prognoses of all patients were ***:Five patients with a mean age of 52.00±7.23y were diagnosed as *** patients were previously diagnosed with hereditary transthyretin amyloidosis caused by the TTR Gly83Arg *** opacity was found in all 10 eyes,and 7 eyes developed RAA 2 to 20y after the onset of hereditary transthyretin *** clinical manifestations were recurrent vitreous hemorrhage in 2 eyes(29%),neovascular glaucoma in 2 eyes(29%),and iris neovascularization in 1 eye(14%).Microangioma lesions were found in all affected eyes that underwent fundus fluorescein angiography(FFA)in this group of cases,and the incidence of the retinal non-perfusion area was 67%.Although no cases of retinal neovascularization were found,the prognosis of visual acuity was not ***:This is the first report of RAA in patients with the TTR Gly83Arg *** such as RAA and glaucoma will seriously affect the visual prognosis of ***,regular ophthalmic follow-up of patients with hereditary transthyretin amyloidosis is *** FFA after vitrectomy is very important,which can help ophthalmologists detect RAA earlier and treat it in time.

关键词： retinal amyloid angiopathy hereditary transthyretin amyloidosis fundus fluorescein angiography vitrectomy retinal photocoagulation

Non-arteritic anterior ischemic optic neuropathy combined with branch retinal vein obstruction:A case report

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世界临床病例杂志 2023年第26期11卷 6189-6193页

作者： Hong-Xia Gong Shi-Yong Xie Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye HospitalTianjin 300020China College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Neuroophthalmology Nankai University Affiliated Eye HospitalTianjin 300020China

BACKGROUND Non-arteritic anterior ischemic optic neuropathy(NAION)is an independent disease characterized by edematous optic *** eyes with branch retinal vein occlusion(BRVO),the arteries and veins in the ethmoid plate of the optic disc are relatively crowded;however,a combination of the two is clinically ***,we reported a patient with NAION and concealed BRVO,for which the treatment and prognosis were not similar to those for NAION *** SUMMARY Herein,we report a case of NAION with concealed BRVO that did not improve with oral medication.A week later,we switched to intravenous drug administration to improve circulation,and the patient’s visual acuity and visual field *** therapy was not administered throughout the *** case suggested that:(1)fundus fluorescein angiography(FFA)can help detect hidden BRVO along with the NAION diagnosis;(2)intravenous infusion of drugs to improve circulation has positive effects in treating such patients;and(3)NAION with concealed BRVO may not require systemic hormonal therapy,in contrast with the known treatment for simple *** NAION may be associated with hidden BRVO,which can only be observed on FFA;intravenous therapy has proven effectiveness.

关键词： Non-arteritic anterior ischemic optic neuropathy Branch retinal vein occlusion fundus fluorescein angiography Field Vision Prognosis Case report

Combined hamartoma of the retina and retinal pigment epithelium:A case report

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World Journal of Clinical Cases 2023年第8期11卷 1788-1793页

作者： Qing Ren Ning Han Rui Zhang Ruo-Fan Chen Peng Yu Department of Ophthalmology The Second Hospital of Jilin UniversityChangchun 130022Jilin ProvinceChina

BACKGROUND Combined hamartoma of the retina and retinal pigment epithelium(CHRRPE)is a rare congenital benign tumor which is commonly *** CHRRPE comprises slightly raised lesions at the posterior pole,with proliferation membrane often leading to vascular *** severe cases,macular edema,macular hole,retinal detachment or vitreous hemorrhage may *** with atypical clinical manifestations are prone to misdiagnosis by inexperienced *** SUMMARY A 33-year-old man reported onset of right eye blurred vision for one week *** segment and intraocular pressure were normal in both *** eye fundus photography was *** eye ophthalmoscopy showed vitreous hemorrhage and off-white raised retinal lesions below the optic *** membranes on the lesion surfaces resulted in superficial retinal detachment and tortuosity and occlusion of peripheral blood vessels.A horseshoe-like tear in the temporal periphery was surrounded by retinal *** coherence tomography revealed retinal thickening at the focal site with structural disturbance indicated by high *** eye ultrasound showed retinal thickening at the lesion,stretching and uplifting of the proliferative membrane,with moderately patchy echo at the optic disc *** and antibodies were detected in vitreous fluids during the operation to rule out other *** fluorescein angiography(FFA)at postoperative follow-up led to final diagnosis of *** FFA is helpful in diagnosing retinal and retinal pigment epithelial combined *** addition,other cytokine and etiological tests facilitate further differential diagnosis to rule out other suspected diseases.

关键词： Combined hamartoma of the retina and retinal pigment epithelium Ocular toxoplasmosis fundus fluorescein angiography Vitreous hemorrhage Retinal tears Case report

The Natural History of Dry Type of Age-related Macular Degeneration

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眼科学报 1993年第1期9卷 31-33页

作者： Feng Wen, De-Zheng Wu, Lezheng Wu National Ophthalmological Laboratories, Ministry of Public Health, China Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences Guangzhou 510060, China National Ophthalmological Laboratories Ministry of Public Health China.

To study the natural history of dry type of age-related macular degeneration (AMD) and search for a sensitive method for detecting the development of the disease, the fundus fluorescein angiography, visual acuity, electroretinogram and FM 100-hue test were used to examine 75 eyes, 147 eyes, 73 eyes, and 94 eyes respectively. These examinations were taken at least twice during the follow-up periods. The average age was 63.2 years (50-80 years ). The average follow-up was 29.8 months with a range of 3-74 ...

关键词： age-related macular degeneration fundus fluorescein angiography electroretinogram color vision natural history.

Characteristics of fundus autofluorescence in cystoid macular edema

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Chinese Medical Journal 2011年第2期124卷 253-257页

作者： PENG Xi-jia SU Lan-ping Department of Ophthalmology Rehabilitation Center Hospital of Gansu Lanzhou Gansu 730000 China

Background fundus autofluorescence （FAF） imaging is a fast and noninvasive technique developed over the last *** authors utilized fluorescent properties of lipofuscin to study the health and viability of the retinal pigment epithelium （RPE）-photoreceptor *** the intensity and distribution of FAF of various retinal diseases is helpful for ascertaining diagnosis and evaluating *** this study,we described the FAF characteristics of cystoid macular edema （CME）.Methods Sixty-two patients （70 eyes） with CME were subjected to FAF and fundus fluorescein angiography （FFA） by a confocal scanning laser ophthalmoscope （Heidelberg Retina Angiograph 2 （HRA2））.Characteristics of FAF images were compared with FFA *** FAF intensity in normal subjects was highest at the posterior pole and dipped at the *** cases of CME showed fluorescein dye accumulated into honeycomb-like spaces in macular and formated a typical petaloid pattern or atypical petaloid pattern in the late phases of the ***-one eyes with CME on FAF images showed mild or moderate hyperautofluorescence petaloid pattern in fovea,the FAF patterns of these CME was perfectly corresponding with shape in their FFA images;nine eyes with CME secondary to exudative age related macular degeneration （AMD） showed expansion of the hypoautofluorescence without petaloid pattern in *** FAF imaging can be used as a new rapid,non-invasive and ancillary technique in the diagnosis of the majority of CME,except for AMD and small part of other fundus diseases.

关键词： cystoid macular edema fundus autofluorescence lipofuscin retinal pigment epithelium fundus fluorescein angiography