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Postpartum depression and major depressive disorder:the same or not?Evidence from resting-state functional MRI

Psychoradiology 2022年第3期2卷 121-128页

作者： Bochao Cheng Yi Guo Xijian Chen Bin Lv Yi Liao Haibo Qu Xiao Hu Haoxiang Yang Yajing Meng Wei Deng Jiaojian Wang Department of Radiology West China Second University Hospital of Sichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Rehabilitation Medicine West China Second University HospitalSichuan UniversityChengdu 610041China Department of Psychiatry West China Hospital of Sichuan UniversityChengdu 610041China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhouZhejiang 310063China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Background Although postpartum depression(PPD)and non-peripartum major depressive disorder(MDD)occurring within and outside the postpartum period share many clinical characteristics,whether PPD and MDD are the same or not remains *** The current study was devoted to identify the shared and different neural circuits between PPD and MDD by resting-state functionalmagnetic resonance imaging data from 77 participants(22 first-episodic drug-naleMDD,26 drug-nale PPD,and 29 healthy controls(HC)).Results Both the PPD andMDD groups exhibited higher fractional amplitude of low-frequency fluctuation(fALFF)in left temporal pole relative to the HC group;the MDD group showed specifically increased degree centrality in the right cerebellum while PPD showed specifically decreased fALFF in the left supplementary motor area and posterior middle temporal gyrus(pMTG_L),and specifically decreased functional connectivities between pMTG and precuneus and between left subgeneual anterior cingulate cortex(sgACC_L)and right ***,sgACC and left thalamus showed abnormal regional homogeneity of functional activities between any pair of HC,MDD,and *** These results provide initial evidence that PPD and MDD have common and distinct neural circuits,which may facilitate understanding the neurophysiological basis and precision treatment for PPD.

关键词： postpartum depression major depressive disorder resting-state fMRI functional activity functional connectivity

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Study on Marine actinomycetes and analysis of their secondary metabolites

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Life Research 2023年第4期6卷 1-15页

作者： Bao-Liang Xu Yuan-Yuan Wang Chun-Ming Dong College of Marine and Environmental Sciences Tianjin University of Science and TechnologyTianjin 300457China

Actinomycetes are relatively prevalent bacteria in the ocean,constituting 9% of the total number of marine *** advancement of science and technology has led to a more profound exploration of marine *** studies hold immense significance in comprehending the distribution and adaptation of marine actinomycetes within the oceanic environment,as well as uncovering new secondary *** on differing lifestyles,marine actinomycetes can be categorized as free-living or *** activity and metabolism of actinomycetes vary across diverse marine settings,including the deep sea,benthic regions,and marine *** to their distinctive biological traits and genetic background,these marine actinomycetes inevitably generate metabolites possessing unique *** methodologies concerning marine actinomycetes predominantly encompass traditional pure culture techniques,molecular biology approaches,and the integration of metagenomics and *** exploration of varied methodologies proves pivotal for the analysis of metabolite *** the cultivation of marine actinomycetes,numerous compounds featuring novel structures and significant activities have been isolated,furnishing a substantial foundation for new drug *** encompass,but are not restricted to,peptides,antibiotics,terpenoids,ketones,quinones,macrolides,and *** potential applications of marine actinomyces and their secondary metabolites extend beyond antibacterial and anti-tumor effects,exhibiting promising prospects in antifungal and antiviral *** paper provides a comprehensive review of the classification,resources,research methodologies,and habitats of marine ***,it delves into the classification of secondary metabolites and their functional activities,facilitating a more exhaustive analysis of the secondary metabolites produced by marine actinomycetes.

关键词： Marine actinomyces secondary metabolites research method functional activity

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Research Progress in the Extraction and Application of Flavonoids from Ginkgo biloba Leaves

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Meteorological and Environmental Research 2023年第2期14卷 50-52,56页

作者： Lili SONG Kaili LI College of Life Science Cangzhou Normal UniversityCangzhou 061001China

Ginkgo biloba resources in China are enormous. With the demand of the market, the preparation and application of flavonoids have become a current research hotspot. The main active substances in G. biloba leaves, flavonoids, have various functional activities and are widely used in fields such as food, medicine, cosmetics, feed, etc. In this paper, the introduction, functional activity, extraction methods, and application research of flavonoids from G. biloba leaves are reviewed, and the development prospects of flavonoids from G. biloba leaves are expected.

关键词： Flavonoids from G.biloba leaves functional activity Extraction method Application and prospects

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A New Class of Highly Potent and Selective Endomorphin-1 Analogues Containing α-Methylene-β-aminopropanoic Acids(Map)

A New Class of Highly Potent and Selective Endomorphin-1 Ana...

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第十一届全国博士生学术年会

作者： Yuan Wang Yanhong Xing Xin Liu Rui Wang Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciencesand Institute of Biochemistry and Molecular BiologySchool of Life SciencesLanzhou University

In this paper a new class of endomorphin-l(EM-1) analogues were synthesized by introduction of novel unnatural a-methylene-β-amino acids(Map) at position 3 or/and *** binding and functional activity,metabolic stability and antinociceptive activity were determined and *** of these analogues showed high affinities for the/t-opioid receptor and an increased stability in mouse brain homogenates than *** of cAMP accumulation and EKR1/2 phosphorylation in HEK293 cells confirmed the agonist properties of these *** found that,compared to EM-1,the incorporation of our synthesized Map at position 4 would bring the analogue to a closer binding mode with theμ-opioid receptor.

关键词： antinociception endomorphin-1 functional activity opioid peptide structure-activity relationships unnatural amino acids

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