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FFA in synovial fluid is possibly related to the attack of acute gouty arthritis

FFA in synovial fluid is possibly related to the attack of a...

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第九届全国免疫学学术大会

作者： Li Zheng Chun Li Fanlei Hu Yingni Li Hongjiang Liu Xuewu Zhang Zhanguo Li Department of Rheumatology and Immunology Peking University People’s Hospital

Background:It is the excessive consumption of food or alcohol that elicits the inflammation of acute gout *** is also related to metabolic *** the mechanism of initiates flares of gout remains poorly ***:The aim of this study is to exam the concentration of FFA(free fat acid)in serum and SF(synovial fluid)of patients with gouty arthritis and hyperuricemia and to investigate the relationship between FFA and the attack of gouty ***:Forty-three patients with gouty arthritis(22 under acute attack and 21 during the intermission of attack),22patients with hyperuricemia and 23 healthy individuals were involved and the levels of FFA in serum were *** of FFA in SF were detected from 30 patients with gouty arthritis and 11 patients with OA(osteoarthritis).The levesl of FFA in both serum and SF were evaluated by ACS·ACOD ***:The circulating FFA in patients with acute gouty arthritis was remarkably higher than that in healthy controls(1.04±0.27 mEq/L VS 0.67±0.13 mEq/L,p<0.05),which was also significantly elevated compared to hyperuricemia patients(0.72±0.20 mEq/L,p<0.05)and gout patients in the intermission of attack(0.77±0.15 mEq/L,p<0.05).Level of FFA in SF in patients with acute gouty arthritis was considerably higher than that in patients with OA(0.34±0.03mEq/L VS 0.19±0.02 mEq/L,p<0.001).Conclusions:The circulating FFA was elevated in patients with acute gouty ***,the levesl of FFA in SF was much higher in patients with acute gouty arthritis,which was possibly related to the attack of acute gouty arthritis.

关键词： gouty arthritis hyperuricemia free fat acid synovial fluid

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