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Clinical application of free/total PSA ratio in the diagnosis of prostate cancer in men over 50 years of age with total PSA levels of 2.0-25.0 ng ml^(−1) in Western China

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Asian Journal of Andrology 2022年第2期24卷 195-200页

作者： Xue-Dan Gao Qiang Miao Jun-Long Zhang Jian-Zhao Zhai Xue-Mei Gui Yi-Han Cai Qian Niu Bei Cai Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine West China Hospital of Sichuan UniversityChengdu 610041China Department of Laboratory Medicine Nan’an Chinese Medicine HospitalChongqing 400060China

The goal of this study was to investigate the clinical application of free/total prostate-specific antigen(F/T PSA)ratio,considering the new broad serum total PSA(T-PSA)“gray zone”of 2.0–25.0 ng ml^(−1)in differential diagnosis of prostate cancer(PCa)and benign prostate diseases(BPD)in men over 50 years in Western China.A total of 1655 patients were included,528 with PCa and 1127 with *** T-PSA,free PSA(F-PSA),and F/T PSA ratio were *** operating characteristic curves were used to assess the efficiency of PSA and F/T PSA *** were 47.4%of cancer patients with T-PSA of 2.0–25.0 ng ml^(−1).When T-PSA was 2.0–4.0 ng ml^(−1),4.0–10.0 ng ml^(−1),and 10.0–25.0 ng ml^(−1),the area under the curve(AUC)of F/T PSA ratio was 0.749,0.769,and 0.761,*** best AUC of F/T PSA ratio was 0.811 when T-PSA was 2.0–25.0 ng ml^(−1),with a specificity of 0.732,a sensitivity of 0.788,and an optimal cutoff value of 15.5%.The AUC of F/T PSA ratio in different age groups(50–59 years,60–69 years,70–79 years,and≥80 years)was 0.767,0.806,0.815,and 0.833,respectively,and the best sensitivity(0.857)and specificity(0.802)were observed in patients over 80 *** T-PSA trend was in accordance with the Gleason score,tumor node metastasis(TNM)stage,and American Joint Committee on Cancer prognosis ***,the F/T PSA ratio can facilitate the differential diagnosis of PCa and BPD in the broad T-PSA“gray zone”.Serum T-PSA can be a Gleason score and prognostic indicator.

关键词： free/total prostate-specific antigen ratio gray zone prostate-specific antigen prostate cancer total prostate-specific antigen

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总体和自由型前列腺特异抗原指数在日本人群前列腺癌筛选中的价值和局限性(英文)

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Asian Journal of Andrology 2006年第4期8卷 429-434,514-515页

作者： Noboru Hara YasuoKitamura ToshihiroSaito ShuichiKomatsubara Department of Urology Niigata Cancer Center HospitalNiigata 951-8133Japan Division of UrologyDepartment of Regenerative and Transplant MedicineGraduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Department of Urology Niigata Cancer Center HospitalNiigata 951-8133Japan

Aim:To assess the efficacy and limitation of free/total prostate-specific antigen ratio(f/tPSA)at a single institution in Japan,focusing on the avoidance of pointless prostate ***:In total,631 men between 44 and 93 years old(mean 69.8 years)with elevated PSA underwent power-Doppler ultrasoundgraphy-guided transrectal 10-core prostate biopsies at Niigata Cancer Center Hospital,and their histological features were investigated with total PSA (tPSA)and f/***:PCa was detected in 126 of 134 patients(94.3%)with tPSA of 26 ng/mL or *** detection rate was 59.4% for tPSA of 21-25 ng/mL,followed by 39.2% for 16-20 ng/mL,30.0% for 11-15 ng/mL, 20.0% for 4.1-10 ng/mL and 7.6% for≤4.0 ng/mL,f/tPSA of the PCa group was significantly lower than that of non-malignamt disorders in any tPSA ranges(mean 0.122 vs.0.160,P<0.001).Receiver-operating characteristics analyses showed that f/tPSA(AUC:0.664)performed more valuably than tPSA(AUC:0.559)in patients with tPSA between 3.0-10 ng/mL(P<0.01).Although f/tPSA of 0.250 for the cut-off value might miss 1.8% PCa patients,it potentially spares 9.2% of unnecessary ***:f/tPSA is more valuable compared with tPSA alone for the prediction of the occurrence of *** recommend 0.250 as the cut-off value for f/tPSA in PCa screening for Asian men having so-called grey-zone tPSA.(Asian J Androl 2006 Jul;8:429-434)

关键词： prostate cancer screening free/total prostate-specific antigen ratio multi-site biopsy single-institutional trial

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