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EXPRESSION OF fragile histidine triad AND P53 IN NON-SMALL CELL LUNG CANCER

Chinese Journal of Cancer Research 2006年第2期18卷 121-126页

作者：侯兴华张道荣 Department of Pathology Anshan Central Hospital The Sixth Clinical College China Medical University Anshan 114001 Department of Pathology Basic Medical College China Medical University Shenyang 110001

Objective： To investigate the expression offragile histidine triad （FHIT） and p53 protein in non-small cell lung cancer （NSCLC） and explore the relationship between their expressions and the clinicopathological features. Methods： FHIT protein and p53 protein were detected by immunohistochemistry in 76 cases of NSCLCs and matched normal lung tissues. Results： Fifty-one cases （67.1%） showed negative expression of FHIT （apparent reduction or loss） and thirty-seven cases （48.7%） showed p53 positive expression （overexpression）. The difference was significant （P=0.04）. However, there was no significant difference in FHIT expression between the p53-positive group and the p53-negative group （64.9% versus 69.2%, P=0.686）. The negative rate of FHIT protein expression was higher in squamous cell carcinoma than in adenocarcinoma, in moderately and poorly differentiated carcinoma than in well-differentiated carcinoma, and in cases with smoking history than in cases without smoking history （P〈0.05）. There was no relationship between FHIT expression and clinical stage or lymph node metastasis. The negative FHIT expression was not an independent predictor of overall survival （P=0.338）. Conclusion： The frequency of negative expression of FHIT protein is higher than that of positive expression of p53 in NSCLCs. The negative expression of FHIT is independent of the expression of p53. The change of expression of FHIT may play a role in the smoking related lung tumorigenesis while it may have no relationship with the progress of NSCLC or prognosis of the patients.

关键词： fragile histidine triad P53 Lung neoplasm Non-small cell lung cancer Immunohistochemistry

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Relationship between Methylation of FHIT and CDH13 Gene Promoter Region and Liver Cancer

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Current Medical Science 2020年第3期40卷 502-509页

作者： Ao-dun TUOYA Dong-xue WANG Yu-shu XING Rui-jun LIU Yu-xia HU Meng-di ZHANG Tu-ya BAI Xiao-li LV Jun LI Fu-hou CHANG The Affiliated Hospital of Inner Mongolia Medical University Hohhot010010China Department of Pharmacology of Pharmaceutical College Inner Mongolia Medical UniversityHohhot010010China The Center for New Drug Safety Evaluation and Research of Inner Mongolia Medical University Hohhot010010China Inner Mongolia Research Center for Drug Screening Hohhot010110China

In order to demonstrate the relationship between methylation of fragile histidine triad(FHIT)and T-cadherin/H-cadherin(CDH13)genes and liver cancer,the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver *** phenol-chloroform method was used to extract genomic *** methylation specific polymerase chain reaction method was applied to detect the methylation status of FHIT and *** relationship between smoking and alcohol consumption and gene(FHIT and CDH13)methylation was *** was significant difference in methylation rate of FHIT(72.67%,34.67%)and CDH13(72.0%,28.0%)between liver cancer patients and healthy individuals of Mongolian descent(P<0.05),as well as that of FHIT(68%,30.67%)and CDH13(64%,26%)between liver cancer patients and healthy individuals of Han individuals(P<0.05).There was also a relationship between smoking and drinking and the methylation of FHIT and CDH13(P<0.05).Thus,the methylation of FHIT and CDH13 had a relationship with liver cancer *** and alcohol ingestion may promote the methylation of FHIT and CDH13.

关键词： liver cancer fragile histidine triad T-cadherin/H-cadherin methylation susceptibility

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Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer

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Frontiers of Medicine 2007年第2期1卷 147-156页

作者： CAO Jie CHEN Xiaoping LI Wanglin XIA Jie DU Hong TANG Weibiao CHEN Shanming WANG Hui CHEN Xiwen XIAO Huanqing LI Yuyuan Department of Gastrointestinal Surgery Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Center of Hepatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Scientific Research and Education Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China Department of Gastroenterology Affiliated Guangzhou First People’s HospitalGuangzhou Medical CollegeGuangzhou 510180China

The fragile histidine triad(FHIT)gene,a candidate tumor suppressor gene located at 3p14.2,has been shown to be involved in the carcinogenesis of many human tissues,including digestive tract ***,the expression and the role of the FHIT in the initiation and the development of the colorectal cancer(CRC)are poorly *** have shown that the FHIT gene exhibits significantly decreased expression in human CRC compared to colorectal adenoma and normal colorectal tissue by tissue microarray(TMA).The positive rate of FHIT gene expression in normal colorectal tissue,adenoma and adenocarcinoma were 93.75%,68.75%and 46.25%,*** show this decreased expression to be significantly correlated with the progression of colorectal carcinoma(P<0.05)as well as with differentiation and lymph node metastasis(P<0.05).We detected two somatic alterations in the FHIT gene in human *** presence of this mutation correlated significantly with decreased FHIT expression in the human *** our present study we tested the hypothesis that the decreased FHIT expression resulted in apoptosis inhibition associated with abnormal expression of apoptosis related *** test this hypothesis we did a series of *** the first test,we assessed apoptosis status using a standard TUNEL(terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling)assay by comparing FHIT-positive CRC ***-negative *** the second experiment,the protein expression of the FHIT and other apoptosis related proteins(Bax,Bcl-2 and Survivin)were measured in human CRC by *** combined results demonstrate the mutation in the FHIT gene significantly reduced FHIT expression in human *** TUNEL and TMA experiments demonstrated significantly inhibited apoptosis by down-regulation of Bax and the up-regulation of Survivin and ***,these studies identify the mechanism by which an important tumor suppressor gene,FHIT is inactivated specifically in human CRC contribut

关键词： fragile histidine triad expression apoptosis colorectal cancer

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