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Expression of FGF-2 and IGF-1 in diabetic rats with fracture

Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 71-75页

作者： Qing-Quan Chen Wan-Ming Wang Department of Orthopaedics.Fuzhou General Hospital of Nanjing Military Area

Objective:To observe the change of fibroblast growth factor-2(FGF-2),insulin-like growth factor-1(IGF—1)in serum and bone callus after fracture in diabetic rats,and to explore molecular biological mechanism of healing of diabetic ***:Thirty male SD rats were designed into normal(n=13)and control(n=!5)groups *** blood was extracted on the 1st,2nd,4th,6th,8th week after *** was certificated and the serum was *** lower extremity was observed by *** callus at broken ends was observed under light *** of FGF-2 and 1GF-1 in tissue were detected by immunohistochemistry method,and ELISA was used to detect expression of FGF-2 and IGF-I in ***:The results showed a significant increase in the density and area of newly formed bone in the distraction gaps of normal rats compared to control *** cell proliferation was also found in the distraction gaps of normal rats versus control *** was significant difference in serum levels of FGF-2 and IGF-1 between two ***:The decrease of FGF-2 and IGF-1 both in the serum and in the fracture region is one of the reasons for bad bone healing or delayed union in rats'fracture with *** are some synergistic effects possibly between FGF-2 and ICF-I.

关键词： Diabetes fraeture healing FGF-2 IGF-1

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Comparison of parathyroid hormone （1-34） and elcatonin in postmenopausal women with osteoporosis： an 18-month randomized, multicenter controlled trial in China

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Chinese Medical Journal 2013年第3期126卷 457-463页

作者： LI Ying XUAN Miao WANG Bo YANG Jun ZHANG Hong ZHANG Xiu-zhen GUO Xiao-hui Lü Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he LIU Zhi-min LI Cheng-jiang WU Tian-feng SHENG Zheng-yan LI Peng-qiu TONG Jiu-cui Department of Endocrinology Tongji Hospital of Tongji University Shanghai 200065 China Department of Endocrinology Peking University First Hospital Beijing 100034 China Department of Endocrinology General Hospital of Chinese People's Liberation Army Beijing Military Region Beijing 100700 China Department of'Endocrinology Beijing Hospital Beijing 100730 China Department of Endocrinology Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China Department of Endocrinology Xijing Hospital of Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Endocrinology Changzheng Hospital Second Military Medical University Shanghai 200003 China Department of Endocrinology First Affiliated Hospital of Zhejiang University Hangzhou Zhejiang 310003 China Department of Endocrinology Zhejiang' Hospital Hangzhou Zhejiang 310013 China Department of Endocrinology Shanghai First People's Hospital Shanghai 200080 China Department of Endocrinology Sichuan Provicial People's Hospital Chengdu Sichuan 610072 China Anhui Provincial Center for Clinical Evaluation of Drug Wuhu Anhui 241001 China

Background Recombinant human parathyroid hormone （1-34）（rhPTH （1-34）） is the first agent in a unique class of anabolic therapies acting on the skeleton. The efficacy and safety of long-term administration of rhPTH （1-34） in Chinese postmenopausal women had not been evaluated. This study compared the clinical efficacy and safety of rhPTH （1-34） with elcatonin for treating postmenopausal women with osteoporosis in 11 urban areas of China. Methods A total of 453 postmenopausal women with osteoporosis were enrolled in an 18-month, multi-center, randomized, controlled study. They were randomized to receive either rhPTH （1-34） 20 μg （200 U） daily for 18 months, or elcatonin 20 U weekly for 12 months. Lumbar spine （L1-4） and femoral neck bone mineral density （BMD）, fracture rate, back pain as well as biochemical markers of bone turnover were measured. Adverse events were recorded. Results rhPTH （1-34） increased lumbar BMD significantly more than did elcatonin after 6, 12, and 18 months of treatment （4.3% vs. 1.9%, 6.8% vs. 2.7%, 9.5% vs. 2.9%, P 〈0.01）. There was only a small but significant increase of femoral neck BMD after 18 months （2.6%, P 〈0.01） in rhPTH groups. There were larger increases in bone turnover markers in the rhPTH （1-34） group than those in the elcatonin group after 6, 12, and 18 months （serum bone-specific alkaline phosphatase （BSAP） 93.7% vs. -3.6%; 117.8% vs. -4.1%; 49.2% vs. -5.8%, P 〈0.01; urinary C-telopeptide/creatinine （CTX/Cr） 250.0% vs. -29.5%; 330.0% vs. -41.4%, 273.0% vs. -10.6%, P 〈0.01）. rhPTH （1-34） showed similar effect of pain relief as elcatonin. The incidence of clinical fractures was 5.36% （6/112） in elcatonin group and 3.2% （11/341）in rhPTH （1-34）group （P=0.303）. Both treatments were well tolerated. Hypercaluria （9.4%） and hypercalcemia （7.0%） in rhPTH （1-34） group were transient and caused no clinical symptoms. Pruritus （8.2% vs. 2.7%, P=0.044） and redness of injection site （4.4% vs. 0,P=0.024） were more frequent in rhPTH （1-34）. N

关键词： recombinant human parathyroid hormone elcatonin osteoporosis bone mineral density fraeture

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