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Biomedical and Environmental Sciences 2016年第12期29卷 898-901页

作者： JIA Hai Xian HAN Jun Hua LI Hu Zhong LIANG Dong DENG Tao Tao CHANG Su Ying China National Center for food Safety Risk Assessment Beijing 100022China Institute of Nutrition and food Hygiene Beijing Center for Diseases Prevention and ControlBeijing 200023China United Nations Children's Fund Beijing 200600China

In the Chinese national nutrition surveys, fortified foods were not investigated separately from the base diet, and the contribution of fortified foods to micronutrients intake is not very clear. This study investigated the diet, including fortified foods and food supplements, of urban pregnant women and analyzed the intake of calcium, iron,and zinc to assess the corresponding contributions of fortified foods, food supplements, and the base diet. The results demonstrated that the base diet was the major source of calcium, iron, and zinc, and was recommended to be the first choice for micronutrients intake. Furthermore, consumption of fortified foods and food supplements offered effective approaches to improve the dietary intake of calcium, iron, and zinc in Chinese urban pregnant women.

关键词： Mineral intake Base diet Fortifiedfood food supplements

Anti-inflammatory evaluation and acute toxicity of three food supplements that contain Moussonia deppeana

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 134-140页

作者： Gabriel Alfonso Gutiérrez-Rebolledo Mariana Zuleima Pérez-González Alejandro Zamilpa María Adelina Jiménez-Arellanes Unidad de Investigación Médica en Farmacología Hospital de EspecialidadesCentro Médico Nacional Siglo XXI(CMN-SXXI)Instituto Mexicano del Seguro Social(IMSS)Av.Cuauhtémoc 330Col.DoctoresDeleg.Cuauhtémoc06720 Ciudad de México(CDMX)Mexico Centro de Investigación Biomédica del Sur(CIBIS) IMSSArgentina No.1Col.Centro62790 XochitepecMorelosMexico

Objective:To identify the anti-inflammatory activity through two murine models and in the median Lethal Dose(LD_(50)) of three dietary supplements that contain Moussonia deppeana.Methods:The anti-inflammatory activity of three dietary supplements(Cicatrisan/Gastricus^(R),Gastinol^(R),and Gastrovita^(R)) EtOH extracts was evaluated by TPA and by carrageenan murine models;also,median Lethal Dose(LD_(50)) was determined.Verbascoside was quantified by High-Performance Liquid Chromatography.β-sitosterol,stigmasterol and the mixture of ursolic and oleanolic acids were identified in all supplements by TLC;however,none of these dietary supplements contain verbascoside.Results:For the TPA model,Cicatrisan/Gastricus^(R)generated a notable effect with 38.24%inhibition.While in the carrageenan model,it also exhibited noteworthy anti-inflammatory activity of ear edema with 66.39%of paw edema inhibition at 150 mg/kg,followed by Gastinol^(R) and Gastrovita^(R) with 50%at 300 mg/kg.Finally,LD_(50) was >2 g/kg for all supplements,when was administered intragastrically and Body Weight(BW) gain in mice was not altered after 14 days.Conclusions:Of the three food supplements containing M.deppeana,only the EtOH extract from the Cicatrisan/Gastricus^(R)formulation(tablets) showed significant anti-inflammatory activity in both experimental models and the LD_(50) was > 2 g/kg.

关键词： Moussonia deppeana food supplements Acute inflammation Mexican medicinal plants Herbal remedies Traditional medicine

Vitamin D in food supplements:Labeling Survey

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Journal of Integrative Medicine（双语） 2021年第2期10卷 43-48页

作者： Alexandra Figueiredo Maria Deolinda Auxtero Maria Guilhermina Moutinho Inês Neves Raquel Inez Isabel Margarida Costa Instituto Universitário Egas Moniz(IUEM) Monte de CaparicaPortugal Centro de Investigação Interdisciplinar Egas Moniz(CiiEM) Egas MonizQuinta da GranjaAlmadaPortugal

An adequate vitamin D(vitD)intake(Recommended Daily Allowance,RDA=5μg)is crucial for health maintenance and its deficiency is associated with several health problems.The increase in hypovitaminosis D cases and the proliferation of food supplements(FS)that are easily accessible by the population,have led to an unrestrained chronic consumption of FS.VitD may accumulate in the body and originate toxicity(Tolerable Upper Limit,UL=100μg).The aim of this study was to evaluate if daily vitD doses mentioned in FS labels are in conformity with RDA.210 solid and liquid FS(for pediatrics and adults)sold in Portuguese pharmacies,supermarkets,health shops and on the internet were examined for indicated daily intake of vitD and compared to RDA and UL values.51.43%of FS have values higher than RDA,8.57%higher than UL.The average vitD daily dose in FS is 24.48μg,with a high variability between samples(0.25-250μg).Majority of FS labels recommend vitD daily doses above RDA and some even above UL,regardless of being for adults or children.Therefore,it is crucial that vitD dose in FS is reviewed to ensure the safety of these products.

关键词： Vitamin D food supplements RDA Safety Labelling Daily dose

Effects of bioactive compounds from Pleurotus mushrooms on COVID-19 risk factors associated with the cardiovascular system

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Journal of Integrative Medicine 2022年第5期20卷 385-395页

作者： Eduardo Echer dos Reis Paulo Cavalheiro Schenkel Marli Camassola Department of Physiology Federal University of Rio Grande do SulCampus Centro 90050-170 Porto AlegreBrazil Enzymes and Biomass Laboratory Institute of BiotechnologyUniversity of Caxias do Sul95070-560 Caxias do SulBrazil Department of Physiology and Pharmacology Federal University of PelotasCampus Capão do Leão96900-010 PelotasBrazil

Mushrooms are a group of fungi with great diversity and ultra-accelerated metabolism.As a consequence,mushrooms have developed a protective mechanism consisting of high concentrations of antioxidants such as selenium,polyphenols,β-glucans,ergothioneine,various vitamins and other bioactive metabolites.The mushrooms of the Pleurotus genus have generated scientific interest due to their therapeutic properties,especially related to risk factors connected to the severity of coronavirus disease 2019(COVID-19).In this report,we highlight the therapeutic properties of Pleurotus mushrooms that may be associated with a reduction in the severity of COVID-19:antihypertensive,antihyperlipidemic,antiatherogenic,anticholesterolemic,antioxidant,anti-inflammatory and antihyperglycemic properties.These properties may interact significantly with risk factors for COVID-19 severity,and the therapeutic potential of these mushrooms for the treatment or prevention of this disease is evident.Besides this,studies show that regular consumption of Pleurotus species mushrooms or components isolated from their tissues is beneficial for immune health.Pleurotus species mushrooms may have a role in the prevention or treatment of infectious diseases either as food supplements or as sources for pharmacological agents.

关键词： Pleurotus food supplements COVID-19 SARS-Cov-2 Coronavirus Antiviral agents

Pathways for Sustainable Utilization of Waste Chicken Eggshell

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Journal of Renewable Materials 2022年第8期10卷 2217-2246页

作者： Omojola Awogbemi Daramy Vandi Von Kallon Victor Sunday Aigbodion Department of Mechanical and Industrial Engineering Technology University of JohannesburgJohannesburgSouth Africa African Centre of Excellence ACESPED University of NigeriaNsukkaNigeria Faculty of Engineering and the Built Environment University of JohannesburgJohannesburgSouth Africa

Chicken eggshell is one of the most common wastes generated from households,restaurants and other food processing outlets.Waste Chicken Eggshells(WCES)also constitutes an environmental nuisance and ends up discarded at dumping site with no consideration of further usage.The main constituent of WCES is calcium carbonate from which calcium or calcium oxide can be extracted for various applications.This current effort reviews recently published literature on the diverse applications of WCES.The considered utilization avenues include catalysts for biofuel production,construction industry,wastewater purification,industrial sector,food industry,medical,and agricultural applications.The specific areas of application apart from the transesterification reactions include cement additives and replacement in concrete,asphalt binder,adsorbent of metals and dyes,production of hydroxyapatite,food supplement and fortification,dentistry,therapeutics,bone formation,drug delivery,poultry feeds as well as organic fertilizer.For most of the identified applications,the WCES is subjected to pretreatment and other modification techniques before utilization.The conversion of WCES to valuable products is a cost-effective,safe,environmentally friendly,non-toxic and viable means of waste disposal and utilization.More investigations are needed to further explore the benefits derivable from this bioresource.

关键词： Waste chicken eggshells catalysts food supplements medical applications waste utilization biofuel production

The potential toxic side effects of flavonoids

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BIOCELL 2022年第2期46卷 357-366页

作者： ZHIMEI TANG QIANG ZHANG School of Biology and food Engineering Guangdong University of Petrochemical TechnologyMaoming525000China

Flavonoids are a class of phytochemical molecules abundant in many plants,fruits,vegetables,and leaves.Flavonoids possess a series of significant biological activities,including anticancer,antioxidant,antiviral,and antiinflammatory properties.They become an important source of dietary supplements and natural health products.Though many studies confirmed the safety of flavonoids,the potential toxicity of flavonoids is still a remarkable field of research to be explored.The enthusiasm for flavonoids expressed by the public has sometimes overlooked their toxicity and also consumed the flavonoids exceeding the body requirements.The current review focused on the potential toxicity of flavonoids to make the public consume flavonoids with caution.This review summarizes the current toxicity which has been reported in vivo and in vitro experiments.The toxicity involves carcinogenicity and mutation,liver and kidney toxicity,and the influence on the thyroid and reproductive function and intestinal flora disorders.The mechanism of toxicity is fully complicated,and current evidence indicates that natural flavonoid glycosides act on different targets with different doses in vivo and in vitro experiments.Though most kinds of flavonoids are considered safe,flavonoids proposed as food supplements need to be assessed their tolerable upper intake level as there have been reports of toxic flavonoids.

关键词： Flavonoids food supplements Toxicity Safety assessment

Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

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Fungal Diversity 2013年第5期62卷 1-40页

作者： Dilani D.De Silva Sylvie Rapior Enge Sudarman Marc Stadler Jianchu Xu S.Aisyah Alias Kevin D.Hyde Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina World Agroforestry Centre East Asia NodeBeijingChina Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany Faculty of ScienceUniversity of PeradeniyaPeradeniya 20500Sri Lanka Laboratory of Botany Phytochemistry and Mycology Faculty of PharmacyUniversity Montpellier 1UMR 5175 CEFEBP 1449115avenue Charles Flahault34093 Montpellier Cedex 5France Department of Microbial Drugs Helmhotz Centre for Infection ResearchBraunschweigGermany Institute of Ocean and Earth Sciences University of Malaya50603 Kuala LumpurMalaysia

Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades,providing drugs or lead compounds of considerable therapeutic potential.This research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological activities.Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic agents.Many novel biologically active compounds have been reported as a result of research on medicinal mushrooms.In this review,we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.The main emphasis is on their anti-Alzheimer,antidiabetic,anti-malarial,anti-microbial,anti-oxidant,antitumor,anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today.Moreover,the reader’s attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits.

关键词： Medicinal mushrooms Anti-oxidant Anti-tumor Anti-HIV Anti-microbial Anti-viral Hypocholesterolemic Anti-diabetic Anti-Alzheimer Anti-malarial food supplements

Omega-3 Fatty Acids and Risk of Atrial Fibrillation: A Case Report and Literature Review

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Open Journal of Internal Medicine 2022年第1期12卷 52-55页

作者： Adnan M. A. Hajjiah Zouheir I. Bitar Frcpuk Ossama Sajeh Maadarani Mohamad Abdelfatah Pharmacy Department Clinical Pharmacy Unit Ahmadi Hospital Ahmadi Kuwait Internal Medicine Department Ahmadi Hospital Ahmadi Kuwait Critical Care Unit Ahmadi Hospital Ahmadi Kuwait Kuwait Oil Company Ahmadi Kuwait

Omega-3 fatty acids are one of the most used food supplements. However, atrial fibrillation has been recently presented as a rare adverse drug event following ingestion of high doses of this food supplement.

关键词： Atrial Fibrillation Omega-3 food supplements