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中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Gregory Ladics DuPont Company Haskell Global Centers for Human Health and Environmental Sciences

An extensive safety assessment process exists for novel proteins used as enzymes in food and *** part of the mammalian safety assessment,novel proteins are evaluated for their toxicological *** is accomplished by employing a holistic approach where the host organism,gene,and the gene product（i.e.,protein） are *** relevant questions initially asked include:1) Does the host organism have a history of safe use in the manufacture of enzymes? Or does the lack of pathogenicity or toxicity still need to be established? To help answer this first question,an established principle that the safety of the production organism is paramount to the safety of the enzyme（i.e.,safe strain lineage） is employed（Pariza and Foster 1983）;2) Does the expressed protein have a history of safe use? To evaluate a novel protein（s）,a weight-of-evidence approach,which takes into account a variety of factors for an overall assessment of toxicological potential,is *** assessment is based on what is known about the novel protein and protein toxins,including similarity to known toxins（in silico amino acid sequence identity comparisons to protein databases）;stability to pepsin digestion in vitro;acute toxicity evaluation based on OECD Guidelines,mode of action;and exposure level and dietary *** proteins for food and feed use are also evaluated for skin and eye irritation,genotoxic effects,and in some cases（e.g.,proteases） skin *** proteins for food and feed use are further evaluated for safety by conducting repeat dose 90-day feeding studies according to OECD Guidelines in rodents where general health and food consumption,clinical chemistry,hematology,and histopathology are evaluated.

关键词： safety assessment enzymes novel proteins safe strain lineage weight-of-evidence food and feed

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Recent advances in the production of single cell protein from renewable resources and applications

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Carbon Resources Conversion 2024年第2期7卷 38-49页

作者： Danai Ioanna Koukoumaki Erminta Tsouko Seraphim Papanikolaou Zacharias Ioannou Panagiota Diamantopoulou Dimitris Sarris Laboratory of Physico-Chemical and Biotechnological Valorization of food By-Products Department of Food Science&NutritionSchool of EnvironmentUniversity of the AegeanLeoforos Dimokratias 66Myrina 81400LemnosGreece Department of food Science and Human Nutrition Agricultural University of Athens75Iera Odos11855 AthensGreece Laboratory of Edible Fungi Institute of Technology of Agricultural ProductsHellenic Agricultural Organization-Dimitra1Sof.Venizelou14123 LykovrysiGreece

Single Cell Protein(SCP)refers to dry cells of microorganisms,and it constitutes a highly promising and alternative protein source for multiple *** presents a rich nutritional profile containing valuable amino acids and fatty acids,nucleic acids,minerals,and several *** businesses worldwide have introduced SCP into their production cycles,hence expanding the scope of its application in value added market chains such as the edible food *** is produced by a plethora of microorganisms,including fungi,yeasts,bacteria,and algae while many of them are Generally Recognized as Safe(GRAS).Selected microbial strains present satisfying growth capability with high yields when cultivated in renewable ***,production rates and process sustainability could be enhanced via the valorization of industrial and agricultural wastes as the nutrient sources,combined with optimization of process parameters,i.e fermentation mode and feeding strategy,pH,temperature,C/N ratio,agitation rate and oxygen *** review addresses the latest developments made towards the SCP production,highlighting efficient microbial SCP producers,and production systems that valorize solid and liquid streams from several agricultural *** applications,challenges in sensorial-,and safety-aspects as well as consumers perception issues of SCP incorporation into food-related matrices are also discussed.

关键词： Alternative protein Sustainability Sensorial aspects Safety food and feed Packaging applications

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