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Antiviral Activity of the Effective Monomers from folium isatidis Against Influenza Virus in Vivo

Virologica Sinica 2010年第6期25卷 445-451页

作者： Zhao LIU Zhan-qiu YANG Hong XIAO College of Pharmacy South-Central University for Nationalities Wuhan 430074 China Medical Virology Institute Wuhan University Wuhan 430071 China

In order to evaluate the anti-influenza virus activity of the effective monomer from folium isatidis (FI) in vivo,we established mice model with viral pneumonia and divided them into 3 different dose groups,then observed their lung indexes,pulmonary pathological changes,pulmonary virus hemagglitination titers,living time and death *** results showed that the monomer could reduce the pulmonary index from 2.64 to 1.93,1.63 and 1.40 (P0.05),and more effective than 200 mg/kg/d dose of antiviral liquor (P<0.05).

关键词： folium isatidis Monomers Influenza virus Antiviral activity In vivo

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