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Serum folate status among blood donors in south-central China

Journal of Innovative Optical Health Sciences 2022年第2期15卷 42-48页

作者： Yan Ma Huan Deng Mingdi He Ru Yang Gang Shen Wuhan Blood Center-Huazhong University of Science and Technology United Hematology Optical Imaging Center Hubei Institute of Blood Transfusion Wuhan Blood Center WuhanHubei 430030P.R.China Wuhan Blood Center-Huazhong University of Science and Technology United Hematology Optical Imaging Center Britton Chance Center for Biomedical Photonics School of Optical and Electronic Information-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology 430074 P.R.China

folate deficiency has been confirmed to be related to various ***,there are few reports on the folate status of Chinese *** study aims to evaluate the serum folate status of blood donors in south-central *** this study,248 blood donors were *** information on subjects was collected by a brief questionnaire concerning alcohol consumption habits,smoking habits,fruit and vegetable consumption and physical *** serum folate concentration was measured by electrochemiluminescence *** geometric mean serum folate concentration was 13.4 nmoll-1(95%CI,12.7-14.1).The prevalence of serum folate concentrations below 6.8 nmoll-1 was 5.2%(95%CI,2.5-8.0).There were significant differences in serum folate concentrations with respect to sex(p-valuesfolate increased with age(p-valuesfolate(OR=3.48;95%CI:1.01-11.99).An age of 30 years or younger was a risk factor for folate *** blood donors had sufficient serum folate concentrations in south-central *** surveys of folate status should be implemented in China.

关键词： Serum folate folate status folate de¯ciency blood donors folate concentrations

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Effect of a 12-Week Dietary Intervention with Folic Acid or folate-Enhanced Foods on folate status in Healthy Egyptian Women

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Food and Nutrition Sciences 2016年第14期7卷 1339-1351页

作者： Mohammed E. Hefni Mohamed T. Shalaby Rasha A. Mohamed Ahmad M. Elwa Cornelia M. Witthöft Food Industries Department Faculty of Agriculture Mansoura University Mansoura Egypt Department of Chemistry and Biomedical Sciences Linnaeus University Kalmar Sweden Faculty of Nursing Mansoura University Mansoura University Mansoura Egypt Clinical Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt

The Egyptian government introduced wheat-flour fortification with iron and folic acid to reduce the incidence of neural tube defects, but suspended it for technical reasons. We previously developed novel legume foods with enhanced folate content. In this study, we investigated the efficacy of 12-week intervention with folate-enhanced foods versus folic acid supplement in improving folate status in Egyptian women. A randomized, parallel intervention trial with two active groups (n = 19, n = 18) and one blinded control group (n = 20) was executed over 12 weeks. Volunteers received either germinated legume foods and orange juice (≈250 μg/d folate) or folic acid supplement (500 μg/d) or apple juice (0 μg/d folate). folate status was assessed by erythrocyte and plasma folate and total homocysteine (tHcy) at day 0, and after 8 and 12 weeks of intervention. After 12 weeks, mean plasma folate increased by 14 (P folate concentration increased in the folic acid group from 614 to 912 (P folate concentrations exceeding 906 nmol/L. tHcy concentration was decreased by 20% (P = 0.007) and 18% (P = 0.006) in the folic acid and food group, respectively, but remained unchanged in the control group during intervention. folate-enhanced foods effectively improve folate status in women of reproductive age. These foods could be used as a complement to folic acid fortification.

关键词： Folic Acid folate-Enhanced Legume Foods Human Intervention folate status

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