检索结果-南通市图书馆

focal nodular hyperplasia of the liver in 86 patients

Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 52-57页

作者： Shen, Ying-Hao Fan, Jia Wu, Zhi-Quan Ma, Zeng-Chen Zhou, Xin-Da Zhou, Jian Qiu, Shuang-Jian Qin, Lun-Xiu Ye, Qin-Hai Sun, Hui-Chuan Huang, Xiao-Wu Tang, Zhao-You Fudan Univ Zhongshan Hosp Dept Liver Surg Shanghai 200032 Peoples R China

BACKGROUND: focal nodular hyperplasia (FNH), the second most common benign hepatic tumor after hemangioma, is characterized by a stellate central scar and hyperplastic nodules. Although some large FNH may be associated with significant symptoms, more frequently they are discovered incidentally on physical examination or the work-up of unrelated symptoms. Since its nature and pathogenesis are still controversial, accurate diagnosis of FNH based on clinical presentation and radiographic studies is difficult. The purpose of this study was to explore the diagnosis and treatment of FNH. METHODS: Eighty-six FNH patients confirmed pathologically were treated at the Liver Cancer Institute in our hospital from 1996 to 2006. Their clinical manifestions, imaging presentation, pathological findings, and surgical results were analyzed retrospectively. RESULTS: Of the 86 patients with 99 foci, 54 were male and 32 female, with a mean age of 37 years. Eighty patients had a single solitary focus and 6 had multiple foci. Tumor diameter was less than 5 cm in 69 patients, 5-10 cm in 15, and more than 10 cm in 2. The overall rate of correct preoperative diagnosis was 59.3% (51/86) including 32.9% (26/79) by color Doppler flow imaging (CDFI), 60.3% (35/58) by CT, and 77.4% (24/31) by MRI. All the 86 patients underwent resection with good curative effect. CONCLUSIONS: CT and MRI are important diagnostic methods for FNH but it is difficult to make a definite preoperative diagnosis for partial classical and all non-classical FNH patients. We suggest that patients with clinical symptoms or with indefinite diagnosis should accept surgical removal.

关键词： liver focal nodular hyperplasia diagnosis treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

focal nodular hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications

引用

Journal of Clinical and Translational Hepatology 2024年第2期12卷 182-190页

作者： Jaimy Villavicencio Kim George Y.Wu Division of Gastroenterology-Hepatology University of Connecticut Health CenterFarmingtonCTUSA

focal nodular hyperplasia is a benign tumor of the liver that is often found incidentally with *** purpose of this review is to discuss the pathophysiology,rare complications that can occur due to these lesions,and management options.A literature review was performed on clinical trials and case reports involving focal nodular hyperplasia complications and management of these,as well as the proposed pathogenesis underlying these *** exposure to oral contraceptive pills and endogenous hormones have been thought to play a role in the development of these lesions,this has not been *** recently,they are thought to arise as a consequence of a vascular anomaly causing alterations in the expression of angiopoietin *** are rare,but previous cases have reported associated pain,rupture and compression of nearby structures(hepatic vein,stomach,biliary system).Resection of focal nodular hyperplasia is not usually ***,if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk of causing a complication,then surgical resection,radiofrequency ablation or arterial embolization should be considered.

关键词： focal nodular hyperplasia Oral contraceptives Liver lesion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

focal nodular hyperplasia associated with a giant hepatocellular adenoma:A case report and review of literature

引用

World Journal of Hepatology 2021年第10期13卷 1450-1458页

作者： Sergio Gaspar-Figueiredo Amaniel Kefleyesus Christine Sempoux Emilie Uldry Nermin Halkic Department of Visceral Surgery Lausanne University HospitalLausanne 1011Switzerland Department of Pathology Lausanne University HospitalLausanne 1011Switzerland

BACKGROUND focal nodular hyperplasia(FNH)and hepatocellular adenoma(HCA)are wellknown benign liver *** treatment is usually chosen for symptomatic patients,lesions more than 5 cm,and uncertainty of *** SUMMARY We described the case of a large liver composite tumor in an asymptomatic 34-year-old female under oral contraceptive for *** imaging work-out described two components in this liver tumor;measuring 6 cm×6 cm and 14 cm×12 cm×6 *** multidisciplinary team suggested surgery for this young woman with an unclear HCA *** underwent a laparoscopic left liver lobectomy,with an uneventful postoperative *** pathological examination confirmed FNH associated with a large *** manuscript aimed to make a literature review of the current management in this particular situation of large simultaneous benign liver *** The simultaneous presence of benign composite liver tumors is *** case highlights the management in a multidisciplinary team setting.

关键词： Liver focal nodular hyperplasia Hepatocellular adenoma Composite tumor Video vignette Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and focal nodular hyperplasia using Computed Tomographic Spectral Imaging

引用

Journal of Clinical and Translational Hepatology 2021年第3期9卷 315-323页

作者： Weixia Li Ruokun Li Xiangtian Zhao Xiaozhu Lin Yixing Yu Jing Zhang Kemin Chen Weimin Chai Fuhua Yan Department of Radiology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Department of Nuclear Medicine Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic *** study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or ***:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and *** were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and *** CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from *** CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined ***:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH.

关键词： Hepatocellular carcinoma Hepatic hemangioma focal nodular hyperplasia Computed tomography spectral imaging Spectral curve

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of fatty liver background on contrast-enhanced ultrasonographic appearance of focal nodular hyperplasia

引用

Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 610-615页

作者： Lin, Li-Wu Yang, Jia-Jia Lin, Xue-Ying Xue, En-Sheng He, Yi-Mi Gao, Shang-Da Yang, Long Yu, Li-Yun Fujian Med Univ Union Hosp Dept Ultrasound Fuzhou 350001 Peoples R China

BACKGROUND: focal nodular hyperplasia (FNH) is increasingly diagnosed as a result of the advances in imaging studies such as contrast-enhanced ultrasonography (CEUS), enhanced computed tomography and magnetic resonance imaging. However, FNH with atypical features can be difficult to differentiate from other benign and malignant tumors. The aim of this study was to investigate the influence of fatty liver background on the CEUS characteristics of FNH. METHODS: Twenty-six patients with FNH were divided into two groups: group A included 14 patients with fatty liver and group B included 12 patients with normal liver background. Conventional two-dimensional ultrasonography and color Doppler flow imaging (CDFI) were conducted and followed by real-time dual-frame CEUS. RESULTS: On two-dimensional ultrasonography, hypoechoic nodules were present in most of the patients in group A (12/14) and hyperechoic nodules in most of those in group B (7/12). The difference in the nodule echotextures between the two groups was statistically significant (P0.05). On CEUS, nodules with a central spoked-wheel-like enhancement pattern in the early arterial phase were observed in 8 patients in group A and those with an eccentric enhancement pattern in the remaining 6 patients. In this group, 3 patients had hypoechoic nodules in the delayed phase. Eleven of the 14 patients in this group were diagnosed accurately with CEUS. In group B, nodules with a rapid central spoked-wheel-like enhancement pattern in the early arterial phase were found in 8 patients by CEUS and those with rapid an eccentric enhancement pattern in 4. The nodules were found to be continuously enhanced in the delayed phase. All of the patients in group B were accurately diagnosed with CEUS. CONCLUSIONS: A FNH nodule on a background of fatty liver may present a hypoechoic pattern on two-dimensi

关键词： ultrasonography contrast media focal nodular hyperplasia fatty liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complete spontaneous regression of giant focal nodular hyperplasia of the liver: Magnetic resonance imaging evaluation with hepatobiliary contrast media

引用

World Journal of Gastroenterology 2016年第47期22卷 10461-10464页

作者： Giuseppe Mamone Settimo Caruso Kelvin Cortis Roberto Miraglia Department of Diagnostic and Therapeutic Services IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies) Medical Imaging Department Mater Dei Hospital

focal nodular hyperplasia(FNH) of the liver is a benign lesion occurring in 0.6%-3% of the general population that probably reflects a local hyperplastic response of hepatocytes to a vascular abnormality. Most lesions are diagnosed incidentally and the natural history of the disease remains largely unknown. It has been shown that most FNH remain stable, or even regress, over a long follow-up period. We present a patient with FNH of the liver who was followed up for 7 years. A 26-yearold woman with a 5-year history of oral contraceptive use was referred to our hospital in February 2005 for further examination of a liver tumour. The diagnosis of FNH was made using magnetic resonance(MR) imaging with hepatospecific contrast media; this technique allows a correct diagnosis, in particular distinguishing FNH from hepatic adenoma, avoiding an invasive procedure such as the lesion biopsy. After 7-year from the diagnosis, we observed the complete spontaneous regression of the lesion by enhanced MR scanning. In this patient, discontinuation of oral contraceptive use and two childbirths may have influenced the natural history of FNH. To our knowledge, in the English literature there is no report illustrating a complete regression of giant FNH but only studies of decreasing in size. The present case suggests that a young patient with giant FNH should be managed conservatively rather than by resection, because FNH has the potential for spontaneous regression.

关键词： focal nodular hyperplasia Regression Magnetic resonance Oral contraceptives Pregnancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atypical focal nodular hyperplasia of the liver

引用

Hepatobiliary & Pancreatic Diseases International 2011年第1期10卷 104-106页

作者： Muhammad Rizwan Khan Taimur Saleem Tanveer Ul Haq Kanwal Aftab Section of General Surgery Department of Surgery Aga Khan UniversityStadium Road Department of Pathology Aga Khan UniversityStadium Road Section of Interventional Radiology Department of RadiologyAga Khan UniversityStadium Road Aga Khan University Hospital Medical College Aga Khan UniversityStadium Road

BACKGROUND:focal nodular hyperplasia,a benign hepatic tumor,is usually ***,rarely the entity can cause symptoms,mandating intervention. METHOD:We present a case of focal nodular hyperplasia of the liver,which caused a considerable diagnostic dilemma due to its atypical presentation. RESULTS:A 29-year-old woman presented with a 15-year history of a progressively increasing mass in the right upper quadrant which was associated with pain and emesis. Examination showed a firm,mobile mass palpable below the right subcostal margin.A computed tomography scan of the abdomen showed an exophytic mass arising from hepatic segments III and *** biopsy of the hepatic mass was *** showed a vascular tumor that was supplied by a tortuous branch of the proper hepatic artery. Surgical intervention for removal of the mass was undertaken. Intra-operatively,two large discrete tumors were found and completely *** examination showed features consistent with focal nodular hyperplasia. CONCLUSION:This description of an unusual case of focal nodular hyperplasia of the liver highlights the point that the diagnosis of otherwise benign hepatic tumors may be difficult despite extensive work-up in some cases.

关键词： focal nodular hyperplasia atypical liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Large focal nodular hyperplasia is unresponsive to arterial embolization: A case report

引用

World Journal of Clinical Cases 2021年第32期9卷 9977-9981页

作者： Hui Ren Yin-Jie Gao Xue-Mei Ma Shao-Tang Zhou Department of Hepatobiliary and Liver Transplant Center The Fifth Medical CenterChinese People’s Liberation Army General HospitalBeijing 100039China

BACKGROUND focal nodular hyperplasia(FNH)commonly occurs in women;it is usually asymptomatic and sometimes difficult to differentiate from hepatocellular carcinoma(HCC).CASE SUMMARY A large space-occupying lesion in the right lobe of the liver was incidentally detected in an adult man and diagnosed as *** arterial chemoembolization was applied once monthly for 2 years,but the lesion did not decrease in *** was revealed by biopsy to be *** years later,the patient underwent liver resection due to hemorrhage and the pathological examination confirmed *** For a space-occupying lesion,it is prerequisite to pathologically confirm the diagnosis and the corresponding intervention can be effective.

关键词： focal nodular hyperplasia Large focal nodular hyperplasia Transarterial embolization Hepatocellular carcinoma Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Co-existence of hepatocellular adenoma and focal nodular hyperplasia in a young female

引用

World Journal of Hepatology 2012年第11期4卷 314-318页

作者： Dimitrios Dimitroulis Panagiotis Lainas Petros Chara-lampoudis Theodore Karatzas Nikolaos Karidis Gregory Kouraklis Ioanna Delladetsima Nikolaos Karidis Gregory Kouraklis Stratigoula Sakellariou 2nd Department of General Surgery Laiko Hospital University of Athens Medical School 11527 Athens Greece Department of Pathology Laiko Hospital University of Athens Medical School 11527 Athens Greece

focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are both benign hepatocellular lesions, presenting mainly in women of childbearing age in non-cirrhotic, non-fibrotic livers. Simultaneous occurrence of these two lesions is extremely rare. We herein report a case of a young female without any predisposing risk factors who presented to our emergency department complaining of acute abdominal pain. Imaging studies revealed a 6 cm lesion in the right hepatic lobe and a 2.5 cm lesion in the left hepatic lobe, respectively. In view of the patient’s symptoms and lack of a confirmed diagnosis based on imaging, we performed a bisegmentectomy V-VI and a wedge resection of the lesion in segment III by laparotomy. Postoperative course was uneventful and the patient was discharged on the fourth postoperative day. The pathology report demonstrated an HA in segments V-VI and FNH in segment III, respectively. Six months later, the patient remains asymptomatic with normal liver function tests, ultrasound and magnetic resonance imaging follow-up. To our best knowledge, this is the first case to describe simultaneous occurrence of HA and FNH without the presence of any known risk factors for these entities. The uncertainty in diagnosis and acuteness of presenting symptoms were established criteria for prompt surgical intervention.

关键词： Liver surgery Liver disease Hepatocellular adenoma focal nodular hyperplasia Benign hepatic tumor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plane and weighted tri-phase helical CT findings in the diagnosis of liver focal nodular hyperplasia

引用

Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 219-223页

作者： Ai-Min Xu Hong-Yan Cheng Dong Chen Yu-Chen Jia Meng-Chao Wu From the Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China Department of Radiology Eastern Hepatobiliary Surgery Hospital Shanghai 200438 China.

Objective: To analyze the pre- and post-contrast CT findings of liver focal nodular hyperplasia (FNH) so as to improve their diagnostic accuracy. Methods: Pre- and post-contrast tri-phase (arterial, portal venous and delayed) scans were performed in 21 patients with FNH proved surgically and patholo- gically. Transcatheter arterial angiography was per- formed in 2 patients. Results: Pre-contrast scans showed hypodensity in 16 patients, isodensity in 5, and punctate, streak and radial scars in 12. Except central scar, all lesions were markedly and homogeneously enhanced in the arterial phase. Nine of the 21 patients showed dilated and tortuous arteries in the central and peripheral areas of the focus. In the portal venous phase, focal density was decreased, though still higher or slightly higher in FNH than in parenchyma. In the delayed phase, the lesions showed isodensity or slight hypo- density. Enhanced capsules were seen in 3 patients. Dilated arteries and drainage veins were seen on an- giographic images. Conclusion: The characteristic manifestations of FNH on multiphasic helical CT scan are of great sig- nificance in diagnosing FNH and choosing viable therapy.

关键词： liver focal nodular hyperplasia computed tomography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：