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A highly sensitive and selective fluorescence probe for singlet oxygen based on paeoniflorin

A highly sensitive and selective fluorescence probe for sing...

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第十届全国化学生物学学术会议

作者： Manman Li Chengcheng Song Jintao Zhang Huaixia Yang Yanju Liu Pharmacy College Henan University of Chinese Medicine

Creatures produce a lot of reactive oxygen species(ROS) in the metabolic process, and many diseases, deterioration, organism aging and many normal physiological processes are closely related to these free radicals, Singlet oxygen(O) is one of the most important[1]. Singlet oxygen in the body involved in a variety of physiological activities, and in the signal transduction, nerve transmission, muscle tension regulation, peristalsis and platelet healing and so have a very important role. But because O is a strong electrophilic reagent and it can react with some biological molecules such as amino acids, proteins, enzymes and nucleic acids leading to the body’s injury that lead to cell necrosis and cause serious chronic diseases[2]. Detecting singlet oxygen usually use these methods: spectrophotometry, HPLC, fluorescence spectrophotometry,chemiluminescence and electron spin resonance(ESR). The principle of spectrophotometry and fluorescence spectroscopy are to detect the absorbance or fluorescence intensity of the probe changing with the singlet oxygen[3]. Paeoniflorin is an active ingredient of white peony root and belongs to monoterpenoidglucoside compound. It was found that paeoniflorin has the effect of anti-free radical damage and *** has been studied as singlet oxygen probe by fluorescence spectroscopy, the results indicated that paeoniflorin acted as a highly sensitive and selective fluorescent probe for singlet oxygen in aqueous, resulting in 6.25-fold enhancement in neutral medium, and 9.95-fold decrease in alkaline medium, the detection limit is 2.6 and 38.7μM respectively, and the rate constant of the neutral condition was 1.3×10 mol·L·s, Results indicate that paeoniflorin holding great potential to be used as a probe for singlet oxygen in cells with high sensitivity and selectivity.

关键词： singlet oxygen fluorescentprobe paeoniflorin

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