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A ratiometric fluorescent probe for alkaline phosphatase with high sensitivity

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Chinese Chemical Letters 2020年第1期31卷 125-128页

作者： Yangyang Yang Chen Zhang Rizhao Pan Shiwei Zhang Shengtao Yao Yao Tang Weilong Zhu Liyue Wang Weiping Zhu Yufang Xu Xuhong Qian Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China

Alkaline phosphatase(ALP)is one of essential biomarkers in mammalian *** we report a ratiometric probe for ALP,which is rationally designed and synthesized by employing ESIPT fluorophore N-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)benzamide(BTHPB).The enzymatic dephosphorylation converts the probe to BTHPB,which exhibits a large spectral red-shift(120 nm),allowing extremely high sensitivity of ALP sensing at 0.004 mU/*** probe also shows excellent biocompatibility and has been applied for monitoring the endogenic ALP in living cells.

关键词： fluorescent probe Alkaline phosphatase Ratiometric ESIPT Biomarker

Synthesis and application of highly sensitive fluorescent probe for Hg2＋ regulated by sulfur

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Chinese Chemical Letters 2017年第10期28卷 2014-2018页

作者： Siyue Ma Linyang Li Mengyao She Yan Mo Shengyong Zhang Ping Liu Jianli Li Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecule Chemistry College of Chemistry & Materials Science Northwest University Xi'an 710127 China

Rhodamine-based fluorescent probe is widely used in chemical analysis, environmental analysis and life sciences area due to their excellent optical properties. Based on the thiophilic property of Hg2＋, using C = S structural motif as the core segment, our group have designed and synthesized three novel probes containing cinnamyl aldehyde with different substituents, exhibiting high selectivity and excellent sensitivity. The structure-property relationships of these probes have been investigated that the optical change caused by electron withdrawing effect and heavy atom effect. Furthermore, these Hg2＋ probes could be applied in living mice imaging, which provide a promising tool for quantitative mercury（Ⅱ） ion imaging in living organism.

关键词： fluorescent probe Rhodamine 6G Mercury(Ⅱ) ion Electronic effect Biological application

The synthesis and study of the fluorescent probe for sensing Cu^(2+) based on a novel coumarin Schiff-base

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Chinese Chemical Letters 2014年第7期25卷 1082-1086页

作者： Yu-Wei Duan Hao-Yang Tang Yuan Guo Zhan-Ke Song Meng-Jiao Peng Yong Yan Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education College of Chemistry and Materials ScienceNorthwest University School of Automation Xi’an University of Posts and Telecommunications

A novel, fluorescent probe was synthesized from 2,4-dihydroxybenzaldehyde and 8-hydroxyquinoline for sensing Cu2＋ by the naked eye. The structure was confirmed by 1R, MS, 1H NMR, 13C NMR and the spectral properties of the probe were investigated. It exhibited strong fluorescence responses toward Cu2＋ and high selectivity over other metal ions. The binding constant between the probe and Cu2＋ was calculated using Benesi-Hildebrand equation.

关键词： fluorescent probe Schiff-base Copperion Coumarin

A new fluorescent probe with ultralow background fluorescence for imaging of endogenous cellular selenol under oxidative stress

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Chinese Chemical Letters 2017年第10期28卷 1987-1990页

作者： Dan Cheng Yue Pan Bin-Cheng Yin Lin Yuan Xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Lab of Biosystem and Microanaiysis State Key Laboratory of Bioreactor Engineering East China University of Sdence and Technology Shanghai 200237 China

A new fluorescent probe（Rhod-Sec） for selenol detection with ultralow background fluorescence have been developed in this paper, which showed a 380-fold off-on fluorescence response, and the nontoxic Rhod-Sec is well suitable for detecting and imaging both exogenous and endogenous selenol in living cells. It also can be applied to visualize the fluctuation of selenol in HepG2 cells through LPS-induced cells oxidation resistance.

关键词： fluorescent probe Selenol fluorescent imaging Oxidative stress

A ratiometric merocyanine-based fluorescent probe for detecting hydrazine in living cells and zebra fish

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Chinese Chemical Letters 2020年第6期31卷 1508-1510页

作者： Jinliang Han Xiuxiu Yue Jingpei Wang Yun Zhang Benhua Wang Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety Changsha 410083China

We developed a merocyanine-based fluorescent probe,NEPB,for tracing hydrazine(N2 H4)in a ratiometric manner with large Stokes shifts and long emission *** fluorescence color of probe NEPB changed from green to yellow upon addition of *** NEPB displayed high selectivity and sensitivity to hydrazine in solution,and could ratiometrically monitor N2 H4 in living cells and zebrafish with low cytotoxicity.

关键词： fluorescent probe Hydrazine Merocyanine Ratiometric Cell imaging

Highly Sensitive Acidic pH fluorescent probe Based on A Boradiaza-indacene Derivative

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Chemical Research in Chinese Universities 2010年第2期26卷 249-251页

作者： LIU Yang LIU Shan-lin WANG Yan-guang Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China

A pH-sensor with a pKa value of 5.05 based on 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene（BODIPY） dye was synthesized and demonstrated to be highly sensitive within a pH range of 4.0--6.0 and was highly photostable, which makes it a potential pH fluorescent probe. The new pH-sensor will find its application in studying acidic organelles in living cells.

关键词： fluorescent probe pH-sensor 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene

Fluorescein-derived fluorescent probe for cellular hydrogen sulfide imaging

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Chinese Chemical Letters 2014年第7期25卷 1060-1064页

作者： Hui-Ying Liu Miao Zhao Qing-Long Qiao Hai-Jing Lang Jing-Zhe Xu Zhao-Chao Xu Department of Chemistry Yanbian University Dalian Institute of Chemical Physics Chinese Academy of Sciences

In this work, a fluorescein-derived fluorescent probe for H2S based on the thiolysis of dinitrophenyl ether is reported. This probe exhibits turn-on fluorescence imaging of H2S in living cells and bulk solutions with ... 详细信息

关键词： fluorescent probe H2S Fluorescein Thiolysis

Synthesis of Coumarin-Pillar[5]arene as a Selective fluorescent probe for Methyl-Parathion

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中国化学:英文版 2015年第3期33卷 368-372页

作者： Fan Zhang Xianliang Cao Demei Tian Haibing Li Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education College of ChemistryCentral China Normal UniversityWuhanHubei 430079China

A novel coumarin-pillar[5]arene derivative(P5C10)was *** spectroscopy indicates that P5C10 shows good selectivity towards methyl-parathion.A combination of NMR spectra,MALDI-TOF spectra and computational calculations ... 详细信息

关键词： fluorescent probe pillararene methyl-parathion host-guest

Visualizing nitric oxide-dependent HIF-1 activity under hypoxia with a lipid droplet-targeting fluorescent probe

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Chinese Chemical Letters 2021年第12期32卷 3895-3898页

作者： Ying-Hao Pan Xiao-Xiao Chen Lei Dong Na Shao Li-Ya Niu Qing-Zheng Yang Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

Evaluating the correlation between hypoxia inducible factor 1(HIF-1) and nitric oxide(NO) generated under hypoxia is of great significance. In this work, we developed a fluorescent probe for the monitor of HIF-1 activity influenced by NO under hypoxia in hepatoma cells with dual-targeting for hepatocyte and lipid droplet(LD). The probe shows excellent selectivity to NO and high sensitivity with 6000-fold fluorescence enhancement. Live cell imaging experiments revealed the probe’s capability of imaging exogenous and endogenous NO with specific in LDs of Hep G2 cells. For cells under hypoxia, HIF-1 induced LD level is observed to correlate with NO level. This work provides the in-situ visualization of NO-dependent HIF-1 upregulation through LD accumulation.

关键词： Bodipy fluorescent probe HIF-1 Lipid droplet Nitric oxide