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Study of possibility of cell recognition in brain tumors

Frontiers of Optoelectronics 2020年第4期13卷 371-380页

作者： Yulia S.MAKLYGINA Alexei S.SKOBELTSIN Tatiana A.SAVELIEVA Galina V.PAVLOVA Ivan V.CHEKHONIN Olga I.GURINA Anastasiya A.Chernysheva Sergey A.Cherepanov Victor B.LOSCHENOV Prokhorov General Physics Institute of the Russian Academy of Sciences Moscow 119991.Russia National Research Nuclear University MEPhI Moscow 115409Russia Institute of Gene Biology Russian Academy of SciencesMoscow 119334Russia Burdenko Neurosurgical Institute Moscow 125047Russia Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health Moscow 119034.Russia

The brain has an exceptionally high requirement for energy metabolism,with glucose serving as the exclusive energy ***,including glioblastoma,have a high glucose uptake and rely on aerobic glycolysis for energy *** alternation of high-efficiency oxidative phosphorylation to a low-efficiency aerobic glycolysis pathway(Warburg effect)provides macromolecules for biosynthesis and *** research indicates that the specific metabolism in the tumor tissue and nonnal brain tissue in the glioma allows the use of 5-aminolevulinic acid(5 ALA)-induced protoporphyrin IX(PpIX)and methylene blue(MB)to monitor and correct the development of the *** focus is on the detection of the differences between tumor cells and tumorassociated macrophages/microglia using spectroscopic and microscopic methods,based on the fluorescent signals and the difference in the drug accumulation of photosensitizers(PSs).Since 5 ALA has long been used effectively in the clinic for fluorescent surgical navigation,it was employed as an agent to identify the localization of tumor tissue and study its composition,particularly tumor and immune cells(macrophages),which have also been shown to actively accumulate ***,since PpIX is photodynamically active,it can be considered effective as the main target of tumor tissue for further successful photodynamic *** was employed to visualize resident microglia,which is important for their activation/deactivation to prevent the reprogramming of the immune cells by the ***,using two drugs,it is possible to prevent crosstalk between tumor cells and the immune cells of different geneses.

关键词： fluorescent diagnostics spectroscopic method video fluorescent method photosensitizer(PS) brain microglia macrophages 5-aminolevulinic acid(5 ALA) methylene blue(MB)

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